iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046915

UUCD1 version

UUC-HoS-00507

Ensembl Protein ID

ENSP00000327738.3

UniProt Accession

Q8N9V2; Q96BE5; TRIML_HUMAN

Genbank Protein ID

BAC04185.1; AAH15684.1; AAI13861.1; AAI14470.1

Protein Name

Probable E3 ubiquitin-protein ligase TRIML1; RING finger protein 209; RING-type E3 ubiquitin transferase TRIML1; Tripartite motif family-like protein 1

Genbank Nucleotide ID

AK093499; AC138781; BC113860; BC114469

Gene Name

TRIML1; RNF209

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000184108.7	ENST00000332517.3	ENSP00000327738.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
ClinVar
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	8.80e-06	27.8	16	56

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlC 45
           C iCl+ f+  p+++ CgH f++ Cl   w     + ++  +CP C
   Q: 16   CFICLDYFSS-PVTTECGHSFCLVCLlRSW----EEHNTPLSCPEC 56
           9*******99.9*************9999*....8899999***99 PP

Organism

Homo sapiens

Functional Description
(View)

Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development.

Protein Sequence
(Fasta)

MSTADLMENL REELTCFICL DYFSSPVTTE CGHSFCLVCL LRSWEEHNTP LSCPECWRTL 60
EGPHFQSNER LGRLASIARQ LRSQVLQSED EQGSYGRMPT TAKALSDDEQ GGSAFVAQSH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGAAGAGA TAAGGGTTTC TTGTCATAAC AACATAGGAA CAGGTCACCC GCGTGTTACT 60
CAAAACTGTA GGACGGCAGT GAGGGCTTTG CTAATCCCAG AACAGAGGTG TAACCTGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0016567--P:protein ubiquitination

KEGG

hsa:339976

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-012712	Bos taurus	84.27	0.00e+00	764.00
IUUC-Cja-018766	Callithrix jacchus	87.61	0.00e+00	773.00
IUUC-Cpo-021715	Cavia porcellus	83.84	0.00e+00	768.00
IUUC-Csa-023087	Chlorocebus sabaeus	95.73	0.00e+00	859.00
IUUC-Cho-024949	Choloepus hoffmanni	78.87	9.00e-116	410.00
IUUC-Dno-029166	Dasypus novemcinctus	79.27	0.00e+00	730.00
IUUC-Dor-030305	Dipodomys ordii	77.78	0.00e+00	677.00
IUUC-Ete-032718	Echinops telfairi	72.28	1.00e-102	366.00
IUUC-Eca-033698	Equus caballus	83.08	0.00e+00	773.00
IUUC-Eeu-035283	Erinaceus europaeus	82.91	0.00e+00	763.00
IUUC-Fca-036582	Felis catus	84.70	0.00e+00	773.00
IUUC-Ggo-044958	Gorilla gorilla	97.86	0.00e+00	878.00
IUUC-Itr-048827	Ictidomys tridecemlineatus	86.42	0.00e+00	785.00
IUUC-Laf-054129	Loxodonta africana	84.91	0.00e+00	761.00
IUUC-Mcc-054822	Macaca mulatta	96.37	0.00e+00	866.00
IUUC-Meu-056710	Macropus eugenii	44.95	4.00e-103	368.00
IUUC-Mmr-061607	Microcebus murinus	85.90	0.00e+00	770.00
IUUC-Mdo-061934	Monodelphis domestica	42.32	1.00e-93	337.00
IUUC-Mmu-063427	Mus musculus	80.82	0.00e+00	744.00
IUUC-Mlu-067448	Myotis lucifugus	82.54	0.00e+00	724.00
IUUC-Nle-069288	Nomascus leucogenys	92.23	0.00e+00	715.00
IUUC-Opr-071061	Ochotona princeps	77.73	0.00e+00	731.00
IUUC-Oan-073218	Ornithorhynchus anatinus	44.40	3.00e-108	385.00
IUUC-Ocu-074593	Oryctolagus cuniculus	87.05	0.00e+00	810.00
IUUC-Oga-089151	Otolemur garnettii	84.91	0.00e+00	781.00
IUUC-Ptr-090993	Pan troglodytes	98.50	0.00e+00	883.00
IUUC-Pan-092038	Papio anubis	96.15	0.00e+00	865.00
IUUC-Pab-097830	Pongo abelii	70.73	1.00e-171	595.00
IUUC-Pca-100976	Procavia capensis	80.35	0.00e+00	718.00
IUUC-Pva-102952	Pteropus vampyrus	77.99	0.00e+00	689.00
IUUC-Rno-105301	Rattus norvegicus	81.25	0.00e+00	738.00
IUUC-Sha-107471	Sarcophilus harrisii	41.97	2.00e-84	306.00
IUUC-Sar-113165	Sorex araneus	86.55	8.00e-115	407.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence