iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062983

Ensembl Protein ID

ENSMODP00000016381.2

UniProt Accession

F7EXR1; F7EXR1_MONDO

Protein Name

Uncharacterized protein

Gene Name

NOD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000013087.2	ENSMODT00000016683.2	ENSMODP00000016381.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/CARD	68.02	0.00e+00	1126.00	IUUC-Hsa-046093

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MERVSTSSSK LMYPTLARRL LDFAKVKDNG VAQFLLQHIL QLPVLPVPLP DVTACKKYTA 60
KLKATVSAQS RFLSTYDGTE NLCLENIYTE NILEIRKNLS LGVPSQKGHD TLELAEIFNH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCGCTGGC GCTGCCAGAA CTTTGGTGGC AGAGCCCAGG CTGCTGGAGG GGCAGACAGG 60
AGCAGGCGGA GTCAATGGCC TGAGTGATCT TGCAGGTGTG TGGAAGGGTC GGGGAGAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS51450--LRR
PS50837--NACHT

Pfam

PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0008180--C:COP9 signalosome
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0071225--P:cellular response to muramyl dipeptide
GO:0002374--P:cytokine secretion involved in immune response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001822	Ailuropoda melanoleuca	67.13	0.00e+00	1020.00
IUUC-Ame-011021	Astyanax mexicanus	48.61	0.00e+00	808.00
IUUC-Bta-013241	Bos taurus	68.52	0.00e+00	1145.00
IUUC-Cja-019633	Callithrix jacchus	61.99	0.00e+00	772.00
IUUC-Cfa-020039	Canis familiaris	67.83	0.00e+00	1120.00
IUUC-Cpo-022337	Cavia porcellus	64.93	0.00e+00	1041.00
IUUC-Csa-023906	Chlorocebus sabaeus	67.09	0.00e+00	1125.00
IUUC-Dre-027568	Danio rerio	48.73	0.00e+00	764.00
IUUC-Dno-029098	Dasypus novemcinctus	66.82	0.00e+00	1058.00
IUUC-Dor-031102	Dipodomys ordii	72.46	9.00e-159	554.00
IUUC-Ete-032943	Echinops telfairi	66.46	0.00e+00	945.00
IUUC-Eca-034310	Equus caballus	66.90	0.00e+00	1125.00
IUUC-Eeu-034589	Erinaceus europaeus	69.37	2.00e-136	479.00
IUUC-Fca-036252	Felis catus	72.70	1.00e-155	544.00
IUUC-Gac-041442	Gasterosteus aculeatus	47.99	0.00e+00	735.00
IUUC-Ggo-044861	Gorilla gorilla	68.37	0.00e+00	1093.00
IUUC-Hsa-046093	Homo sapiens	68.02	0.00e+00	1088.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	66.35	0.00e+00	1007.00
IUUC-Lch-049454	Latimeria chalumnae	55.90	0.00e+00	956.00
IUUC-Laf-053553	Loxodonta africana	69.80	0.00e+00	1041.00
IUUC-Mcc-055772	Macaca mulatta	67.33	0.00e+00	1107.00
IUUC-Meu-056785	Macropus eugenii	82.92	2.00e-139	490.00
IUUC-Mmr-060596	Microcebus murinus	66.74	0.00e+00	1072.00
IUUC-Mmu-063951	Mus musculus	61.38	0.00e+00	1045.00
IUUC-Mpu-066412	Mustela putorius furo	67.36	0.00e+00	1110.00
IUUC-Mlu-067601	Myotis lucifugus	64.23	0.00e+00	1039.00
IUUC-Nle-069913	Nomascus leucogenys	67.67	0.00e+00	1081.00
IUUC-Opr-070999	Ochotona princeps	63.45	0.00e+00	729.00
IUUC-Ont-072512	Oreochromis niloticus	49.60	0.00e+00	818.00
IUUC-Oan-073564	Ornithorhynchus anatinus	65.94	0.00e+00	1001.00
IUUC-Ocu-074837	Oryctolagus cuniculus	67.71	0.00e+00	1085.00
IUUC-Ogu-078061	Oryza glumaepatula	28.92	1.50e+00	29.60
IUUC-Oni-083091	Oryza nivara	26.74	3.30e-01	32.00
IUUC-Ola-086555	Oryzias latipes	49.00	0.00e+00	754.00
IUUC-Oga-088909	Otolemur garnettii	67.25	0.00e+00	1067.00
IUUC-Oar-089315	Ovis aries	67.94	0.00e+00	1095.00
IUUC-Ptr-090542	Pan troglodytes	68.02	0.00e+00	1089.00
IUUC-Pan-092545	Papio anubis	67.21	0.00e+00	1102.00
IUUC-Pma-094167	Petromyzon marinus	32.39	3.00e-62	233.00
IUUC-Ppa-095344	Physcomitrella patens	34.94	8.00e-06	46.20
IUUC-Pfo-096976	Poecilia formosa	48.79	0.00e+00	800.00
IUUC-Pab-098481	Pongo abelii	68.14	0.00e+00	1090.00
IUUC-Pca-100135	Procavia capensis	68.41	0.00e+00	970.00
IUUC-Pva-102127	Pteropus vampyrus	66.40	0.00e+00	1042.00
IUUC-Rno-105783	Rattus norvegicus	64.92	0.00e+00	1038.00
IUUC-Sar-113448	Sorex araneus	61.79	6.00e-164	571.00
IUUC-Tru-118708	Takifugu rubripes	47.24	0.00e+00	717.00
IUUC-Tni-120172	Tetraodon nigroviridis	35.88	1.00e-32	133.00
IUUC-Tca-121582	Theobroma cacao	25.00	2.60e-01	29.30
IUUC-Tbe-127661	Tupaia belangeri	67.86	0.00e+00	662.00
IUUC-Ttr-128318	Tursiops truncatus	60.39	0.00e+00	930.00
IUUC-Vpa-130502	Vicugna pacos	63.13	7.00e-72	265.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence