iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000009073.5	ENSGALT00000068735.1	ENSGALP00000058473.1
ENSGALG00000009073.5	ENSGALT00000014765.5	ENSGALP00000014749.4
ENSGALG00000009073.5	ENSGALT00000057667.1	ENSGALP00000045395.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	5.70e-06	26.7	284	312

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantg 30
           +eta+e++++iFP+l+ys+ + + + +++
   Q: 284  VETAQERNEPIFPALIYSSAMIWTVGMAK 312
           89*********************998875 PP

Organism

Gallus gallus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MITFMNNSDS EDEPCNERTS LMSAESPPVP SYQDGLQASE TREAQTHRKR QTGSSRSPNN 60
VADEDASDSD VRVRESALEN EEEELTLKYG AKHVIMLFVP VTLCMIVVVA TIKSVRFYTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGGCCGAG CGCAGGTACG GGGTGGGGGG GGGGGACGCG GGTCGAGCGT CGGCTGCGGG 60
GTCTCCTCCT GGGCCGGCTC GCTTAAGGGG TGGGCGGGGG GCTCCGGCAC GGGGCTGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

KEGG

gga:374188

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	67.45	2.00e-131	462.00
IUUC-Apl-003959	Anas platyrhynchos	93.12	0.00e+00	725.00
IUUC-Aca-005160	Anolis carolinensis	83.15	0.00e+00	628.00
IUUC-Aly-005455	Arabidopsis lyrata	46.22	1.00e-17	84.00
IUUC-Ath-006730	Arabidopsis thaliana	31.16	2.00e-18	86.70
IUUC-Ame-010686	Astyanax mexicanus	80.90	2.00e-147	514.00
IUUC-Bta-013097	Bos taurus	77.36	2.00e-161	561.00
IUUC-Cja-018824	Callithrix jacchus	76.47	5.00e-158	550.00
IUUC-Cfa-020253	Canis familiaris	76.70	7.00e-161	560.00
IUUC-Cpo-021401	Cavia porcellus	76.03	8.00e-160	556.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	34.10	1.00e-29	124.00
IUUC-Csa-023369	Chlorocebus sabaeus	77.68	6.00e-162	563.00
IUUC-Dre-028526	Danio rerio	70.33	2.00e-146	512.00
IUUC-Dor-031127	Dipodomys ordii	74.73	3.00e-159	554.00
IUUC-Ete-033081	Echinops telfairi	70.32	7.00e-75	274.00
IUUC-Eca-034387	Equus caballus	76.04	3.00e-153	534.00
IUUC-Eeu-034846	Erinaceus europaeus	61.76	1.00e-105	376.00
IUUC-Fca-035396	Felis catus	73.35	5.00e-166	577.00
IUUC-Fal-037457	Ficedula albicollis	89.74	0.00e+00	694.00
IUUC-Gmo-038550	Gadus morhua	71.13	8.00e-132	462.00
IUUC-Gac-042511	Gasterosteus aculeatus	66.60	5.00e-134	470.00
IUUC-Gma-043822	Glycine max	36.51	2.00e-25	109.00
IUUC-Ggo-045338	Gorilla gorilla	77.73	6.00e-162	563.00
IUUC-Hsa-046455	Homo sapiens	77.73	6.00e-162	563.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	77.36	8.00e-163	566.00
IUUC-Lch-049638	Latimeria chalumnae	69.55	1.00e-149	522.00
IUUC-Loc-052427	Lepisosteus oculatus	73.70	2.00e-162	565.00
IUUC-Laf-053758	Loxodonta africana	75.49	1.00e-171	595.00
IUUC-Mcc-054755	Macaca mulatta	77.14	2.00e-161	561.00
IUUC-Mtr-058392	Medicago truncatula	33.33	4.00e-31	128.00
IUUC-Mmr-060890	Microcebus murinus	75.76	6.00e-160	556.00
IUUC-Mdo-062197	Monodelphis domestica	78.14	8.00e-175	606.00
IUUC-Mmu-063823	Mus musculus	75.82	3.00e-161	561.00
IUUC-Mac-064858	Musa acuminata	40.00	1.00e-22	99.80
IUUC-Mpu-066181	Mustela putorius furo	77.14	5.00e-163	566.00
IUUC-Nle-069596	Nomascus leucogenys	74.81	4.00e-147	514.00
IUUC-Opr-070344	Ochotona princeps	76.37	4.00e-164	570.00
IUUC-Ont-071867	Oreochromis niloticus	69.69	2.00e-136	478.00
IUUC-Oan-073378	Ornithorhynchus anatinus	73.59	1.00e-153	535.00
IUUC-Ocu-074652	Oryctolagus cuniculus	75.05	1.00e-160	559.00
IUUC-Obr-076302	Oryza brachyantha	31.58	5.00e-18	85.50
IUUC-Ola-086707	Oryzias latipes	71.61	6.00e-114	403.00
IUUC-Oga-088560	Otolemur garnettii	76.15	6.00e-158	550.00
IUUC-Oar-089200	Ovis aries	74.89	3.00e-159	554.00
IUUC-Ptr-090569	Pan troglodytes	77.51	2.00e-161	561.00
IUUC-Pan-091742	Papio anubis	77.14	1.00e-161	562.00
IUUC-Psi-093297	Pelodiscus sinensis	84.55	8.00e-158	549.00
IUUC-Pma-094612	Petromyzon marinus	76.74	1.00e-127	449.00
IUUC-Ppa-095431	Physcomitrella patens	32.48	5.00e-27	115.00
IUUC-Pab-098531	Pongo abelii	77.68	6.00e-162	563.00
IUUC-Pop-099661	Populus trichocarpa	33.83	1.00e-34	140.00
IUUC-Pca-101120	Procavia capensis	75.16	1.00e-156	545.00
IUUC-Pva-102934	Pteropus vampyrus	71.87	2.00e-156	545.00
IUUC-Rno-106052	Rattus norvegicus	75.60	4.00e-164	570.00
IUUC-Sha-106876	Sarcophilus harrisii	78.40	8.00e-175	606.00
IUUC-Sly-110865	Solanum lycopersicum	47.44	9.00e-09	51.60
IUUC-Ssc-115380	Sus scrofa	77.14	3.00e-167	580.00
IUUC-Tgu-117280	Taeniopygia guttata	89.52	0.00e+00	688.00
IUUC-Tbe-127632	Tupaia belangeri	76.20	5.00e-133	467.00
IUUC-Ttr-129008	Tursiops truncatus	75.82	3.00e-157	548.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence