iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000003442.1	ENSORLT00000004280.1	ENSORLP00000004279.1
ENSORLG00000003442.1	ENSORLT00000004281.1	ENSORLP00000004280.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.00e-114	382.0	155	693

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           GlkN+gNtCYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++ lw k++ ++v p++l++ +k+++++f+gy+q
   Q: 155  GLKNIGNTCYMNAALQALSNCPPLTQFFLE-----CGGLVKTDKKPALCKSYQKLVSDLWhKNRPSYVVPTTLFQGIKAINPMFRGYSQ 238
           9*****************************.....9999999******************99999************************ PP
   S: 90   qDaqEflaflldqleeelkk.....................eknkpkeeeeeedkselsde............................ 129
           qD+qEfl++l+dql+eelk+                     +++++              +                            
   Q: 239  QDSQEFLRCLMDQLHEELKEpmpepndlsngiamgdsmeedNHTQSD-------------Ndfqscescgssdradnevqggnelmgdt 314
           ******************99888887775544444333333222222.............2566666677777799************* PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 315  neaemlipeqeevqanrewqkeknmindlyrsgvnvimsgstgvdidrdvdttsetkpiissqgaikvqsrssecfpdiqmsnstrpqs 403
           ***************************************************************************************** PP
   S: 130  ......................................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
                                                  ++k +kk++s+isd+F+g++ s+++cl+cd+vs++ e+f+d+slp+pgke
   Q: 404  pvsmeghipklsssppkaacgwpslnpshkkavttfspTKSKRQKKYRSIISDVFDGTIVSSVQCLTCDRVSVTLENFQDISLPIPGKE 492
           **************************************999************************************************ PP
   S: 181  etkke.................................................slqdcLesftkeeelegenkyycekckkkqeaekk 220
           + +k+                                                 +lqdcL++f++++el+g+n+y+cekckk+++ +k 
   Q: 493  DLAKLhssthqtslvkagscgeayaaqgwiafvmeyikryalcffsswfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF 581
           99888************************************************************************************ PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.Wl 307
           +k++klPe+L++hLkRf  ++e ++++ki+++v+fple Ldl+pf+++++++q  +++Y+L++v++H+G++ssGHY+ay++n++++ W+
   Q: 582  CKMQKLPEILCIHLKRF--RHELMFSTKISTHVSFPLEgLDLQPFLSKDSSAQ--TTNYDLLSVICHHGTASSGHYIAYCRNDSNNlWY 666
           *****************..9999*************************88877..9**************************99999** PP
   S: 308  lfdDskVtevkeeevleetgstaYvlfYkr 337
           +fdD++Vtev+e+ v++   ++aYvlfYk+
   Q: 667  EFDDQSVTEVSESCVQN---AEAYVLFYKK 693
           *****************...********98 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

PLPSSCDCPH LACVGEITKE ELIQKSHGHC RDCNVKGPNL WACLESGCAY VGCGESHTDH 60
STVHSQESRH NLTVNLTTLR VWCYSCSKEV FLERKLGPHS PHVSFKPLPP PQNVQDAMRD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTGGTTT TAAGGTTAGT AGATTTTGAA CGGCGTTGGC CTGGTGAGCT GGCAAAAGTG 60
GCGTTCTGCT GTTGCTCGCA CAGTTTATAC CAGAATATTG TGAAAATTGA ACACATGAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001742	Ailuropoda melanoleuca	69.36	0.00e+00	1287.00
IUUC-Apl-003987	Anas platyrhynchos	68.68	0.00e+00	1227.00
IUUC-Aca-004713	Anolis carolinensis	66.56	0.00e+00	1211.00
IUUC-Bta-013132	Bos taurus	70.10	0.00e+00	1301.00
IUUC-Cja-018811	Callithrix jacchus	69.82	0.00e+00	1288.00
IUUC-Cfa-021158	Canis familiaris	69.51	0.00e+00	1288.00
IUUC-Cpo-021910	Cavia porcellus	62.35	0.00e+00	1112.00
IUUC-Csa-023130	Chlorocebus sabaeus	69.88	0.00e+00	1290.00
IUUC-Cho-024383	Choloepus hoffmanni	49.26	6.00e-108	385.00
IUUC-Dre-028639	Danio rerio	79.24	0.00e+00	1429.00
IUUC-Dno-029416	Dasypus novemcinctus	69.82	0.00e+00	1256.00
IUUC-Ete-032994	Echinops telfairi	62.03	7.00e-131	461.00
IUUC-Eca-034248	Equus caballus	69.66	0.00e+00	1293.00
IUUC-Eeu-035357	Erinaceus europaeus	54.24	0.00e+00	879.00
IUUC-Fca-036013	Felis catus	67.88	0.00e+00	1249.00
IUUC-Fal-037509	Ficedula albicollis	68.61	0.00e+00	1240.00
IUUC-Gmo-038944	Gadus morhua	78.02	0.00e+00	1411.00
IUUC-Gga-040647	Gallus gallus	68.48	0.00e+00	1225.00
IUUC-Gac-041752	Gasterosteus aculeatus	86.88	0.00e+00	1600.00
IUUC-Hsa-045694	Homo sapiens	69.77	0.00e+00	1279.00
IUUC-Itr-049041	Ictidomys tridecemlineatus	68.91	0.00e+00	1270.00
IUUC-Lch-050400	Latimeria chalumnae	67.78	0.00e+00	1220.00
IUUC-Loc-052616	Lepisosteus oculatus	75.11	0.00e+00	1392.00
IUUC-Laf-053493	Loxodonta africana	70.10	0.00e+00	1293.00
IUUC-Mcc-055542	Macaca mulatta	69.88	0.00e+00	1291.00
IUUC-Meu-056645	Macropus eugenii	61.24	0.00e+00	1058.00
IUUC-Mga-060019	Meleagris gallopavo	69.68	0.00e+00	1057.00
IUUC-Mmr-061241	Microcebus murinus	67.17	0.00e+00	1246.00
IUUC-Mmu-063786	Mus musculus	68.80	0.00e+00	1261.00
IUUC-Mpu-065772	Mustela putorius furo	70.47	0.00e+00	1096.00
IUUC-Mlu-067732	Myotis lucifugus	68.97	0.00e+00	1277.00
IUUC-Nle-069528	Nomascus leucogenys	69.34	0.00e+00	1288.00
IUUC-Opr-070606	Ochotona princeps	65.08	0.00e+00	1138.00
IUUC-Ont-071495	Oreochromis niloticus	89.05	0.00e+00	1628.00
IUUC-Ocu-074457	Oryctolagus cuniculus	68.46	0.00e+00	1277.00
IUUC-Oga-088720	Otolemur garnettii	69.34	0.00e+00	1291.00
IUUC-Oar-089921	Ovis aries	70.21	0.00e+00	1304.00
IUUC-Ptr-090526	Pan troglodytes	69.88	0.00e+00	1283.00
IUUC-Pan-092396	Papio anubis	69.62	0.00e+00	1286.00
IUUC-Psi-092971	Pelodiscus sinensis	69.66	0.00e+00	1282.00
IUUC-Pfo-097415	Poecilia formosa	85.42	0.00e+00	1575.00
IUUC-Pab-098740	Pongo abelii	69.77	0.00e+00	1298.00
IUUC-Pva-102820	Pteropus vampyrus	67.00	0.00e+00	1074.00
IUUC-Rno-104894	Rattus norvegicus	68.59	0.00e+00	1256.00
IUUC-Sha-107244	Sarcophilus harrisii	65.59	0.00e+00	1156.00
IUUC-Sar-113665	Sorex araneus	68.44	0.00e+00	1287.00
IUUC-Ssc-115793	Sus scrofa	69.16	0.00e+00	1252.00
IUUC-Tgu-117487	Taeniopygia guttata	69.83	0.00e+00	1218.00
IUUC-Tru-117694	Takifugu rubripes	81.90	0.00e+00	1568.00
IUUC-Tsy-119598	Tarsius syrichta	61.57	0.00e+00	1050.00
IUUC-Tni-120189	Tetraodon nigroviridis	80.17	0.00e+00	1480.00
IUUC-Tbe-128125	Tupaia belangeri	73.26	4.00e-77	282.00
IUUC-Ttr-128269	Tursiops truncatus	68.66	0.00e+00	1212.00
IUUC-Vpa-130598	Vicugna pacos	67.97	0.00e+00	1253.00
IUUC-Xtr-132044	Xenopus tropicalis	67.75	0.00e+00	1204.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence