iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117694

UUCD1 version

UUC-TaR-01125

Ensembl Protein ID

ENSTRUP00000012806.1

UniProt Accession

H2SK73; H2SK73_TAKRU

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

usp33

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000005338.1	ENSTRUT00000012866.1	ENSTRUP00000012805.1
ENSTRUG00000005338.1	ENSTRUT00000012867.1	ENSTRUP00000012806.1
ENSTRUG00000005338.1	ENSTRUT00000012868.1	ENSTRUP00000012807.1
ENSTRUG00000005338.1	ENSTRUT00000012869.1	ENSTRUP00000012808.1
ENSTRUG00000005338.1	ENSTRUT00000012870.1	ENSTRUP00000012809.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.40e-113	378.0	159	700

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tGlkN+gNtCYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++ lw k+++++v p++l++ +k+++++f+gy+
   Q: 159  TGLKNIGNTCYMNAALQALSNCPPLTQFFLE-----CGGMVRTDKKPALCKSYQKLVSDLWhKNRSSYVVPTNLFQGIKAINPMFRGYS 242
           7******************************.....9999999******************999999********************** PP
   S: 89   qqDaqEflaflldqleeelkk.......eknkpkeeeeeedkselsde......................................... 129
           qqD+qEfl++l+dql+eelk+       +       ++ +     ++e                                         
   Q: 243  QQDSQEFLRCLMDQLHEELKEpmtepygH-------SNTAMIDGNPEEdnhsqsddfqscescdsseradsevrvgnmlrddtneaeml 324
           *******************9955555551.......33333333333344445556788888888899999****************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 325  ipeqdeihatqewqkeknmindlyrssiqsvmgggtgvdmdkdvdtttettpiiscqgamkfqgrasviytyiqmsnitkpqspvlmeg 413
           ***************************************************************************************** PP
   S: 130  ................................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke. 185
                                            ++k++kk++s++sd+F+g++ s+++cl+cd+vs++ e+f+d+slp+pgke+ +k+ 
   Q: 414  hipklsssppktasgwhslnpahkkavttfsqPKNKHQKKYRSVVSDVFDGTIVSSVQCLTCDRVSVTLENFQDISLPIPGKEDLAKLh 502
           *******************************989999**********************************************99888* PP
   S: 186  ...................................................slqdcLesftkeeelegenkyycekckkkqeaekklkl 223
                                                              +lqdcL++f++++el+g+n+y+cekckk+++ +k +k+
   Q: 503  ssthqtslvkagscgeayapqgwiafvmeyikryfynnsfsilswfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKM 591
           ***************************************************************************************** PP
   S: 224  kklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.Wllfd 310
           ++lPe+L++hLkRf  ++e ++++ki+++v+fple Ldl+pf+++++ +q  +++Y+L++v++H+G++ssGHY+ay++n++++ W++fd
   Q: 592  QNLPEILCIHLKRF--RHELMFSTKISTHVSFPLEgLDLQPFLAKDSFSQ--TTNYDLLSVICHHGTASSGHYIAYCRNDENNlWYEFD 676
           **************..9999*************************77666..9**************************99999***** PP
   S: 311  DskVtevkeeevleetgstaYvlfYkr 337
           D++Vtev+e+ v++   ++aYvlfYk+
   Q: 677  DHRVTEVSESCVQN---AEAYVLFYKK 700
           **************...********98 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MAPVSSCDCP HLDCVGEVTK EELIQKSHGQ CQDCKVGGPN LWACLENGCM YVGCGESHAD 60
HSTVHSQETR HNLTVNLTTL RVWCYACSKE VFLERKLGPH SLHQELQLRK TQTSTIQTQQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTCTTCTC TCAGACAAGT TGTGTGGTGC TTATTCAGGT TGCATTAGGA AGGGTCTGTT 60
GCAGTCATAT TACTGTTGAA TGTTGAAGGA TATCTGAATT TAATGTTCTC ATTGAAACCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001742	Ailuropoda melanoleuca	68.35	0.00e+00	1254.00
IUUC-Apl-003987	Anas platyrhynchos	66.81	0.00e+00	1206.00
IUUC-Aca-004713	Anolis carolinensis	65.62	0.00e+00	1196.00
IUUC-Bta-013132	Bos taurus	68.35	0.00e+00	1269.00
IUUC-Cja-018811	Callithrix jacchus	68.43	0.00e+00	1261.00
IUUC-Cfa-021158	Canis familiaris	68.24	0.00e+00	1252.00
IUUC-Cpo-021910	Cavia porcellus	62.81	0.00e+00	1107.00
IUUC-Csa-023130	Chlorocebus sabaeus	68.28	0.00e+00	1261.00
IUUC-Cho-024383	Choloepus hoffmanni	49.26	5.00e-102	365.00
IUUC-Dre-028639	Danio rerio	76.29	0.00e+00	1397.00
IUUC-Dno-029416	Dasypus novemcinctus	68.06	0.00e+00	1238.00
IUUC-Ete-032994	Echinops telfairi	58.87	1.00e-121	431.00
IUUC-Eca-034248	Equus caballus	68.32	0.00e+00	1269.00
IUUC-Eeu-035357	Erinaceus europaeus	53.85	0.00e+00	858.00
IUUC-Fca-036013	Felis catus	66.13	0.00e+00	1207.00
IUUC-Fal-037509	Ficedula albicollis	67.27	0.00e+00	1227.00
IUUC-Gmo-038944	Gadus morhua	76.87	0.00e+00	1390.00
IUUC-Gga-040647	Gallus gallus	66.24	0.00e+00	1203.00
IUUC-Gac-041752	Gasterosteus aculeatus	83.73	0.00e+00	1546.00
IUUC-Hsa-045694	Homo sapiens	68.53	0.00e+00	1254.00
IUUC-Itr-049041	Ictidomys tridecemlineatus	68.82	0.00e+00	1249.00
IUUC-Lch-050400	Latimeria chalumnae	66.28	0.00e+00	1208.00
IUUC-Loc-052616	Lepisosteus oculatus	74.04	0.00e+00	1372.00
IUUC-Laf-053493	Loxodonta africana	67.78	0.00e+00	1254.00
IUUC-Mcc-055542	Macaca mulatta	68.28	0.00e+00	1264.00
IUUC-Meu-056645	Macropus eugenii	59.33	0.00e+00	1036.00
IUUC-Mmr-061241	Microcebus murinus	65.91	0.00e+00	1226.00
IUUC-Mmu-063786	Mus musculus	68.97	0.00e+00	1248.00
IUUC-Mlu-067732	Myotis lucifugus	68.92	0.00e+00	1258.00
IUUC-Nle-069528	Nomascus leucogenys	68.43	0.00e+00	1264.00
IUUC-Opr-070606	Ochotona princeps	64.95	0.00e+00	1130.00
IUUC-Ont-071495	Oreochromis niloticus	84.72	0.00e+00	1551.00
IUUC-Ocu-074457	Oryctolagus cuniculus	67.09	0.00e+00	1253.00
IUUC-Ola-086739	Oryzias latipes	81.90	0.00e+00	1563.00
IUUC-Oga-088720	Otolemur garnettii	68.06	0.00e+00	1267.00
IUUC-Oar-089921	Ovis aries	68.71	0.00e+00	1274.00
IUUC-Ptr-090526	Pan troglodytes	68.57	0.00e+00	1253.00
IUUC-Pan-092396	Papio anubis	68.24	0.00e+00	1264.00
IUUC-Psi-092971	Pelodiscus sinensis	68.64	0.00e+00	1264.00
IUUC-Pfo-097415	Poecilia formosa	82.18	0.00e+00	1497.00
IUUC-Pab-098740	Pongo abelii	68.43	0.00e+00	1269.00
IUUC-Pca-100598	Procavia capensis	64.61	0.00e+00	706.00
IUUC-Pva-102820	Pteropus vampyrus	64.96	0.00e+00	1034.00
IUUC-Rno-104894	Rattus norvegicus	68.97	0.00e+00	1246.00
IUUC-Sha-107244	Sarcophilus harrisii	63.57	0.00e+00	1139.00
IUUC-Sar-113665	Sorex araneus	67.61	0.00e+00	1252.00
IUUC-Ssc-115793	Sus scrofa	68.31	0.00e+00	1229.00
IUUC-Tgu-117487	Taeniopygia guttata	69.15	0.00e+00	1206.00
IUUC-Tsy-119598	Tarsius syrichta	60.46	0.00e+00	1034.00
IUUC-Tni-120189	Tetraodon nigroviridis	86.31	0.00e+00	1613.00
IUUC-Tbe-128125	Tupaia belangeri	70.93	8.00e-77	281.00
IUUC-Ttr-128269	Tursiops truncatus	67.39	0.00e+00	1198.00
IUUC-Vpa-130598	Vicugna pacos	66.49	0.00e+00	1223.00
IUUC-Xtr-132044	Xenopus tropicalis	67.60	0.00e+00	1209.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence