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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046568
UUCD1 version UUC-HoS-00231
Ensembl Protein ID ENSP00000316628.3
UniProt Accession Q8N8N0; B3KV99; Q52LA4; RN152_HUMAN
Genbank Protein ID BAC04805.1; BAG53711.1; AAH94004.1; AAI11957.1
Protein Name E3 ubiquitin-protein ligase RNF152; RING finger protein 152; RING-type E3 ubiquitin transferase RNF152
Genbank Nucleotide ID AK096495; AK122758; AC105094; BC111956
Gene Name RNF152
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000176641.10 ENST00000312828.3 ENSP00000316628.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMIC
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 21203937
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.00e-05 27.6 12 55
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC++ +  ++ p++l+C+H+ +  Clq++    + s+k  rCP+Cr
   Q: 12   CQICFNYYspRRRPKLLDCKHTCCSVCLQQM----RTSQKDVRCPWCR 55
           9*****8888555***************999....99**********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).
 E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).
Protein Sequence
(Fasta)
METLSQDSLL ECQICFNYYS PRRRPKLLDC KHTCCSVCLQ QMRTSQKDVR CPWCRGVTKL 60
PPGFSVSQLP DDPEVLAVIA IPHTSEHTPV FIKLPSNGCY MLPLPISKER ALLPGDMGCR 120
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Protein Fasta Sequence


>IUUC-Hsa-046568|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GTCTGGCTGA AAGGAGCGGG CGCGCCGGGA CCACCCGGCG ATGCTGTCGC CGCCGCCGCC 60
GCCTCTGTAG CGAGCACCCG AGCCCGCCGC GGAGAAAGGT CAGTGAGTTT CGGTTTGTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046568|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR033609--RNF152
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF14634--zf-RING_5
SMART

SM00184--RING
Gene Ontology

GO:0031301--C:integral component of organelle membrane
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0031267--F:small GTPase binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0034198--P:cellular response to amino acid starvation
GO:1904262--P:negative regulation of TORC1 signaling
GO:0010508--P:positive regulation of autophagy
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination
KEGG hsa:220441
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001569 Ailuropoda melanoleuca 96.55 2.00e-114 404.00
IUUC-Aca-004700 Anolis carolinensis 94.09 5.00e-112 396.00
IUUC-Ame-011661 Astyanax mexicanus 55.88 5.00e-50 190.00
IUUC-Bdi-014339 Brachypodium distachyon 35.63 3.10e-02 33.10
IUUC-Cja-019799 Callithrix jacchus 99.01 2.00e-107 381.00
IUUC-Cfa-020144 Canis familiaris 94.58 4.00e-100 357.00
IUUC-Cpo-021632 Cavia porcellus 98.03 5.00e-115 406.00
IUUC-Csa-023858 Chlorocebus sabaeus 99.51 7.00e-108 382.00
IUUC-Cho-024669 Choloepus hoffmanni 95.20 2.00e-68 250.00
IUUC-Dre-027881 Danio rerio 58.82 6.00e-57 213.00
IUUC-Dno-029695 Dasypus novemcinctus 92.12 2.00e-98 351.00
IUUC-Dor-030795 Dipodomys ordii 97.04 9.00e-104 369.00
IUUC-Eca-033412 Equus caballus 98.52 3.00e-107 380.00
IUUC-Fca-036256 Felis catus 97.54 5.00e-107 379.00
IUUC-Fal-036943 Ficedula albicollis 92.61 3.00e-103 367.00
IUUC-Gga-040800 Gallus gallus 93.10 1.00e-110 392.00
IUUC-Ggo-045477 Gorilla gorilla 100.00 3.00e-117 413.00
IUUC-Itr-049081 Ictidomys tridecemlineatus 96.55 3.00e-113 400.00
IUUC-Lch-049770 Latimeria chalumnae 86.21 5.00e-97 346.00
IUUC-Loc-052353 Lepisosteus oculatus 87.83 3.00e-60 223.00
IUUC-Laf-054064 Loxodonta africana 97.04 2.00e-114 404.00
IUUC-Mcc-054875 Macaca mulatta 99.51 7.00e-108 382.00
IUUC-Meu-056370 Macropus eugenii 96.08 4.00e-113 400.00
IUUC-Mga-059847 Meleagris gallopavo 93.10 1.00e-110 391.00
IUUC-Mmr-061337 Microcebus murinus 98.52 3.00e-115 407.00
IUUC-Mdo-063047 Monodelphis domestica 95.10 2.00e-111 394.00
IUUC-Mmu-064228 Mus musculus 97.54 3.00e-109 387.00
IUUC-Mlu-067736 Myotis lucifugus 96.55 6.00e-101 359.00
IUUC-Nle-069697 Nomascus leucogenys 99.51 7.00e-108 382.00
IUUC-Ont-072208 Oreochromis niloticus 76.06 4.00e-87 313.00
IUUC-Oan-073566 Ornithorhynchus anatinus 84.80 3.00e-89 320.00
IUUC-Ocu-074089 Oryctolagus cuniculus 96.06 3.00e-102 363.00
IUUC-Obr-076611 Oryza brachyantha 40.82 2.30e-02 33.50
IUUC-Ola-087210 Oryzias latipes 71.36 7.00e-76 276.00
IUUC-Oga-088395 Otolemur garnettii 98.03 5.00e-105 373.00
IUUC-Oar-090382 Ovis aries 95.83 3.00e-21 92.80
IUUC-Ptr-091480 Pan troglodytes 100.00 3.00e-117 413.00
IUUC-Pan-091715 Papio anubis 99.51 7.00e-108 382.00
IUUC-Psi-093465 Pelodiscus sinensis 95.57 2.00e-112 397.00
IUUC-Pfo-097259 Poecilia formosa 76.89 7.00e-91 326.00
IUUC-Pab-097769 Pongo abelii 100.00 3.00e-117 413.00
IUUC-Pca-100657 Procavia capensis 97.54 3.00e-114 404.00
IUUC-Pva-102521 Pteropus vampyrus 98.03 5.00e-116 409.00
IUUC-Rno-105521 Rattus norvegicus 97.54 6.00e-115 406.00
IUUC-Sha-107197 Sarcophilus harrisii 96.57 2.00e-113 400.00
IUUC-Ssc-116239 Sus scrofa 97.04 9.00e-115 405.00
IUUC-Tru-118315 Takifugu rubripes 75.83 3.00e-83 300.00
IUUC-Tsy-119645 Tarsius syrichta 99.51 5.00e-117 413.00
IUUC-Tni-119835 Tetraodon nigroviridis 75.36 2.00e-87 315.00
IUUC-Tbe-127264 Tupaia belangeri 97.54 4.00e-110 390.00
IUUC-Ttr-128749 Tursiops truncatus 97.54 4.00e-109 387.00
IUUC-Vpa-130808 Vicugna pacos 97.54 4.00e-109 386.00
Created Date 25-Jun-2017

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