iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000034116.17	ENSMUST00000169220.8	ENSMUSP00000126694.2
ENSMUSG00000034116.17	ENSMUST00000005889.15	ENSMUSP00000005889.9
ENSMUSG00000034116.17	ENSMUST00000112870.4	ENSMUSP00000108491.4

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.10e-20	74.5	788	839

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+lk+Gd+++++ +++  +gW++g  e  g+ G fP+n+ve+
   Q: 788  KARYDFCARDRSELSLKEGDIIKIL-NKKGQQGWWRG--EIYGRIGWFPSNYVEE 839
           788**********************.89999******..9*************86 PP

Organism

Mus musculus

Functional Description
(View)

Interacts with SHB (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity (PubMed:10646609, PubMed:10646608). May interact with CCPG1 (PubMed:17000758). Interacts with CLNK (PubMed:11463797). Interacts with THEMIS2 (PubMed:20644716). Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK. Interacts with PTK2B/PYK2 (By similarity). Interacts with HCK. Interacts with PTK2B/PYK2. Interacts (via SH2 domain) with SYK (By similarity). Interacts with ANKRD54 (PubMed:19064729). Interacts with CD6 (PubMed:24584089).

Protein Sequence
(Fasta)

MELWRQCTHW LIQCRVLPPS HRVTWEGAQV CELAQALRDG VLLCQLLNNL LPQAINLREV 60
NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGTAGTTG TCCCCACTGG GGCAGGCGGC GGCGGTGGTG AAGGAACGAG GGTGCACGGG 60
GCCTCCCCGA GGGGCCAAGT GAGAGGCCGG CAGCCACCAT GGAGCTCTGG CGACAGTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR001452--SH3_domain
IPR003096--SM22_calponin
IPR028530--Vav

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00888--SM22CALPONIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005829--C:cytosol
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0030593--P:neutrophil chemotaxis
GO:0006909--P:phagocytosis
GO:0030168--P:platelet activation
GO:0045785--P:positive regulation of cell adhesion
GO:0043547--P:positive regulation of GTPase activity
GO:0045954--P:positive regulation of natural killer cell mediated cytotoxicity
GO:0072593--P:reactive oxygen species metabolic process
GO:0008361--P:regulation of cell size
GO:0043087--P:regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0042110--P:T cell activation
GO:0030217--P:T cell differentiation
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway

KEGG

mmu:22324

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013049	Bos taurus	78.93	0.00e+00	1184.00
IUUC-Cja-020009	Callithrix jacchus	92.78	0.00e+00	1583.00
IUUC-Cfa-020768	Canis familiaris	94.44	0.00e+00	1587.00
IUUC-Dno-029602	Dasypus novemcinctus	93.49	0.00e+00	1585.00
IUUC-Eca-033682	Equus caballus	93.61	0.00e+00	1578.00
IUUC-Fca-035629	Felis catus	93.03	0.00e+00	1605.00
IUUC-Gmo-039693	Gadus morhua	60.40	0.00e+00	964.00
IUUC-Gac-041567	Gasterosteus aculeatus	66.31	0.00e+00	1031.00
IUUC-Hsa-045886	Homo sapiens	93.14	0.00e+00	1590.00
IUUC-Itr-048730	Ictidomys tridecemlineatus	91.61	0.00e+00	1526.00
IUUC-Loc-051761	Lepisosteus oculatus	71.58	0.00e+00	1192.00
IUUC-Laf-054537	Loxodonta africana	92.90	0.00e+00	1579.00
IUUC-Mcc-054726	Macaca mulatta	93.02	0.00e+00	1590.00
IUUC-Mmr-060980	Microcebus murinus	92.81	0.00e+00	1593.00
IUUC-Mdo-061926	Monodelphis domestica	85.70	0.00e+00	1321.00
IUUC-Mpu-066000	Mustela putorius furo	93.85	0.00e+00	1581.00
IUUC-Mlu-067818	Myotis lucifugus	91.17	0.00e+00	1518.00
IUUC-Ont-072213	Oreochromis niloticus	67.56	0.00e+00	1115.00
IUUC-Ocu-074830	Oryctolagus cuniculus	77.45	0.00e+00	1165.00
IUUC-Ola-087345	Oryzias latipes	63.72	0.00e+00	1046.00
IUUC-Oga-089104	Otolemur garnettii	93.96	0.00e+00	1602.00
IUUC-Oar-089459	Ovis aries	92.66	0.00e+00	1561.00
IUUC-Ptr-090766	Pan troglodytes	92.79	0.00e+00	1470.00
IUUC-Pan-091994	Papio anubis	91.96	0.00e+00	1565.00
IUUC-Psi-093595	Pelodiscus sinensis	77.64	0.00e+00	1260.00
IUUC-Pfo-097210	Poecilia formosa	66.27	0.00e+00	1071.00
IUUC-Pab-098630	Pongo abelii	93.12	0.00e+00	1553.00
IUUC-Pva-102406	Pteropus vampyrus	92.07	0.00e+00	1528.00
IUUC-Pte-104123	Pyrenophora teres	48.33	1.00e-10	62.80
IUUC-Pyt-104567	Pyrenophora triticirepentis	52.00	2.00e-10	61.60
IUUC-Rno-105763	Rattus norvegicus	95.15	0.00e+00	1595.00
IUUC-Sha-106683	Sarcophilus harrisii	85.11	0.00e+00	1476.00
IUUC-Sly-111123	Solanum lycopersicum	50.00	2.00e-10	59.70
IUUC-Stu-112434	Solanum tuberosum	50.00	3.00e-10	59.70
IUUC-Sar-113457	Sorex araneus	79.39	0.00e+00	904.00
IUUC-Ssc-115338	Sus scrofa	93.96	0.00e+00	1479.00
IUUC-Tru-118199	Takifugu rubripes	64.38	0.00e+00	1007.00
IUUC-Tni-120548	Tetraodon nigroviridis	64.87	0.00e+00	1032.00
IUUC-Tbe-127235	Tupaia belangeri	70.37	1.00e-137	483.00
IUUC-Vpa-130066	Vicugna pacos	68.42	2.00e-72	267.00
IUUC-Xtr-132410	Xenopus tropicalis	71.21	0.00e+00	1232.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence