iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-115338

Ensembl Protein ID

ENSSSCP00000014402.1

UniProt Accession

F1SCN0; F1SCN0_PIG

Genbank Protein ID

ENSSSCP00000014402

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

CU681822

Gene Name

VAV1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000013553.1	ENSSSCT00000014803.1	ENSSSCP00000014402.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.50e-21	75.7	732	783

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+lk+Gd+++++ +++  +gW++g  e  g+ G fP+n+ve+
   Q: 732  KARYDFCARDRSELSLKEGDIIKIL-NKKGQQGWWRG--EIYGRVGWFPSNYVEE 783
           788**********************.89999******..9*************86 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

IMFLPLSCLS PQFLCLKNIR TFLSTCYEKF GLKRSELFEA FDLFDVQDFG KVICTLSALS 60
WTPIAQNKGI MPFPTEEDSV GDEDIYSGLS DQIDDTVEED EDLYDCVENE EAEGDEIYED 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTATGTTTC TTCCACTCTC ATGTCTCTCC CCACAGTTCC TGTGCCTTAA GAATATCCGT 60
ACTTTCTTGT CTACCTGCTA TGAGAAGTTT GGCCTCAAGC GGAGTGAACT CTTTGAAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR001452--SH3_domain
IPR028530--Vav

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030593--P:neutrophil chemotaxis
GO:0006909--P:phagocytosis
GO:0045785--P:positive regulation of cell adhesion
GO:0045954--P:positive regulation of natural killer cell mediated cytotoxicity
GO:0072593--P:reactive oxygen species metabolic process
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001362	Ailuropoda melanoleuca	56.34	0.00e+00	841.00
IUUC-Apl-003734	Anas platyrhynchos	57.56	0.00e+00	857.00
IUUC-Aca-004477	Anolis carolinensis	55.75	0.00e+00	825.00
IUUC-Ame-011279	Astyanax mexicanus	51.34	0.00e+00	757.00
IUUC-Bta-013049	Bos taurus	82.36	0.00e+00	1264.00
IUUC-Cja-020009	Callithrix jacchus	95.24	0.00e+00	1524.00
IUUC-Cfa-020768	Canis familiaris	97.04	0.00e+00	1503.00
IUUC-Cpo-021966	Cavia porcellus	54.93	0.00e+00	763.00
IUUC-Csa-023892	Chlorocebus sabaeus	55.83	0.00e+00	836.00
IUUC-Cin-025115	Ciona intestinalis	36.91	1.00e-122	434.00
IUUC-Csv-025995	Ciona savignyi	35.88	8.00e-128	451.00
IUUC-Dre-028199	Danio rerio	51.81	0.00e+00	771.00
IUUC-Dno-029602	Dasypus novemcinctus	95.24	0.00e+00	1494.00
IUUC-Eca-033682	Equus caballus	97.04	0.00e+00	1516.00
IUUC-Eeu-034719	Erinaceus europaeus	41.93	2.00e-119	423.00
IUUC-Fca-035629	Felis catus	95.64	0.00e+00	1555.00
IUUC-Fal-036802	Ficedula albicollis	55.38	0.00e+00	843.00
IUUC-Gmo-039693	Gadus morhua	58.06	0.00e+00	875.00
IUUC-Gga-040884	Gallus gallus	56.98	0.00e+00	843.00
IUUC-Gac-041567	Gasterosteus aculeatus	64.67	0.00e+00	930.00
IUUC-Ggo-044460	Gorilla gorilla	54.39	0.00e+00	783.00
IUUC-Hsa-045886	Homo sapiens	95.76	0.00e+00	1534.00
IUUC-Itr-048730	Ictidomys tridecemlineatus	91.14	0.00e+00	1410.00
IUUC-Loc-051761	Lepisosteus oculatus	71.45	0.00e+00	1113.00
IUUC-Lma-053273	Leptosphaeria maculans	52.00	3.00e-10	61.20
IUUC-Laf-054537	Loxodonta africana	95.24	0.00e+00	1506.00
IUUC-Mcc-054726	Macaca mulatta	95.37	0.00e+00	1531.00
IUUC-Meu-056680	Macropus eugenii	51.41	0.00e+00	749.00
IUUC-Mga-060013	Meleagris gallopavo	57.40	0.00e+00	873.00
IUUC-Mmr-060980	Microcebus murinus	94.34	0.00e+00	1495.00
IUUC-Mdo-061926	Monodelphis domestica	87.03	0.00e+00	1344.00
IUUC-Mmu-063942	Mus musculus	93.96	0.00e+00	1480.00
IUUC-Mpu-066000	Mustela putorius furo	96.40	0.00e+00	1494.00
IUUC-Mlu-067818	Myotis lucifugus	93.38	0.00e+00	1463.00
IUUC-Nle-069863	Nomascus leucogenys	53.65	0.00e+00	816.00
IUUC-Opr-070372	Ochotona princeps	47.64	1.00e-144	507.00
IUUC-Ont-072213	Oreochromis niloticus	66.07	0.00e+00	1029.00
IUUC-Ocu-074830	Oryctolagus cuniculus	79.52	0.00e+00	1191.00
IUUC-Ola-087345	Oryzias latipes	62.66	0.00e+00	972.00
IUUC-Oga-089104	Otolemur garnettii	96.27	0.00e+00	1514.00
IUUC-Oar-089459	Ovis aries	96.79	0.00e+00	1534.00
IUUC-Ptr-090766	Pan troglodytes	95.75	0.00e+00	1533.00
IUUC-Pan-091994	Papio anubis	94.48	0.00e+00	1510.00
IUUC-Psi-093595	Pelodiscus sinensis	78.43	0.00e+00	1194.00
IUUC-Pfo-097210	Poecilia formosa	64.54	0.00e+00	984.00
IUUC-Pab-098630	Pongo abelii	95.80	0.00e+00	1498.00
IUUC-Pva-102406	Pteropus vampyrus	95.12	0.00e+00	1449.00
IUUC-Pte-104123	Pyrenophora teres	48.33	7.00e-11	63.20
IUUC-Pyt-104567	Pyrenophora triticirepentis	52.00	1.00e-10	62.00
IUUC-Rno-105763	Rattus norvegicus	90.62	0.00e+00	1418.00
IUUC-Sha-106683	Sarcophilus harrisii	86.14	0.00e+00	1412.00
IUUC-Sly-111123	Solanum lycopersicum	50.00	2.00e-10	59.70
IUUC-Stu-112434	Solanum tuberosum	50.00	2.00e-10	59.70
IUUC-Sar-113457	Sorex araneus	80.41	0.00e+00	945.00
IUUC-Tgu-116595	Taeniopygia guttata	57.03	0.00e+00	853.00
IUUC-Tru-118199	Takifugu rubripes	62.63	0.00e+00	920.00
IUUC-Tsy-119429	Tarsius syrichta	57.09	2.00e-155	543.00
IUUC-Tni-120548	Tetraodon nigroviridis	63.41	0.00e+00	954.00
IUUC-Tvi-122300	Trichoderma virens	25.14	9.00e-15	75.90
IUUC-Tbe-127235	Tupaia belangeri	70.94	2.00e-139	489.00
IUUC-Ttr-128916	Tursiops truncatus	91.04	0.00e+00	984.00
IUUC-Vpa-130066	Vicugna pacos	69.86	5.00e-82	298.00
IUUC-Xtr-132410	Xenopus tropicalis	71.43	0.00e+00	1149.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence