iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052628

Ensembl Protein ID

ENSLOCP00000005553.1

UniProt Accession

W5MAZ4; W5MAZ4_LEPOC

Genbank Protein ID

ENSLOCP00000005553

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01013452

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000004637.1	ENSLOCT00000005561.1	ENSLOCP00000005553.1
ENSLOCG00000004637.1	ENSLOCT00000005575.1	ENSLOCP00000005567.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-126	422.8	451	786

Active Site

Position(s)	Description	Evidence
755	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ +tlq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 451  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 538
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g+  ++eLkp+G+nipVt+eNk+eYv+l+v+
   Q: 539  GFTLPFYKQLLGKPIQLSDLETVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGKFLQHELKPNGRNIPVTEENKKEYVRLYVN 623
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G  +id++d+k++t+ k+ + +ds+ ++wFw+++e+f++e r ++LqFv
   Q: 624  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDNKELELIIGGLGKIDLNDWKANTRLKH-CVADSNIVKWFWQAVESFDEERRGRLLQFV 711
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l ekLl+A+eet gF +
   Q: 712  TGSTRVPLQGFKALQgstgsagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLFEKLLTAVEETCGFAV 786
           ******************************99999**************************************76 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKV VVDGSGQCHS TDTVKSTLDP 60
KWNQHYDLYI GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACAATGCAA ACACACCAAG CTTGGGGGGC GCCGCCTCTC TCTTAAGAAG TAGACGGACA 60
CGACCCCTTT CCTCGCTTTT CCTTTGTCAT CCAGCCCCTG CCTCCCCCTG TCCCGAGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	84.54	0.00e+00	1317.00
IUUC-Apl-004155	Anas platyrhynchos	82.38	0.00e+00	1338.00
IUUC-Aca-005238	Anolis carolinensis	83.90	0.00e+00	1335.00
IUUC-Ame-010901	Astyanax mexicanus	90.09	0.00e+00	1424.00
IUUC-Bta-013221	Bos taurus	82.01	0.00e+00	1285.00
IUUC-Cja-018985	Callithrix jacchus	83.29	0.00e+00	1364.00
IUUC-Cfa-020568	Canis familiaris	81.38	0.00e+00	1312.00
IUUC-Cpo-022531	Cavia porcellus	83.05	0.00e+00	1361.00
IUUC-Csa-024145	Chlorocebus sabaeus	85.41	0.00e+00	1365.00
IUUC-Cho-024963	Choloepus hoffmanni	68.75	0.00e+00	668.00
IUUC-Dre-028341	Danio rerio	89.33	0.00e+00	1427.00
IUUC-Dno-029705	Dasypus novemcinctus	81.68	0.00e+00	1301.00
IUUC-Dme-031740	Drosophila melanogaster	72.54	1.00e-174	607.00
IUUC-Eca-034125	Equus caballus	82.66	0.00e+00	1323.00
IUUC-Fca-035905	Felis catus	84.25	0.00e+00	1320.00
IUUC-Fal-037336	Ficedula albicollis	85.49	0.00e+00	1323.00
IUUC-Gmo-039486	Gadus morhua	80.96	0.00e+00	885.00
IUUC-Gga-040218	Gallus gallus	85.34	0.00e+00	1377.00
IUUC-Gac-041707	Gasterosteus aculeatus	81.83	0.00e+00	1303.00
IUUC-Ggo-045408	Gorilla gorilla	77.64	0.00e+00	1221.00
IUUC-Hsa-045878	Homo sapiens	83.17	0.00e+00	1364.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	82.77	0.00e+00	1322.00
IUUC-Laf-053644	Loxodonta africana	84.94	0.00e+00	1288.00
IUUC-Mcc-055479	Macaca mulatta	78.43	0.00e+00	1218.00
IUUC-Mga-059723	Meleagris gallopavo	84.90	0.00e+00	1317.00
IUUC-Mdo-063005	Monodelphis domestica	85.66	0.00e+00	1380.00
IUUC-Mmu-063634	Mus musculus	85.17	0.00e+00	1353.00
IUUC-Mpu-065898	Mustela putorius furo	84.65	0.00e+00	1322.00
IUUC-Mlu-067584	Myotis lucifugus	82.07	0.00e+00	1320.00
IUUC-Nle-069033	Nomascus leucogenys	82.79	0.00e+00	1327.00
IUUC-Ont-072265	Oreochromis niloticus	81.03	0.00e+00	1315.00
IUUC-Oan-073621	Ornithorhynchus anatinus	84.64	0.00e+00	1362.00
IUUC-Ocu-073960	Oryctolagus cuniculus	81.58	0.00e+00	1292.00
IUUC-Ola-086960	Oryzias latipes	74.32	0.00e+00	1153.00
IUUC-Oga-088579	Otolemur garnettii	83.42	0.00e+00	1368.00
IUUC-Oar-090396	Ovis aries	80.25	0.00e+00	1267.00
IUUC-Ptr-091624	Pan troglodytes	83.17	0.00e+00	1364.00
IUUC-Pan-092479	Papio anubis	82.66	0.00e+00	1325.00
IUUC-Pfo-097203	Poecilia formosa	81.89	0.00e+00	1307.00
IUUC-Pab-097540	Pongo abelii	82.71	0.00e+00	1295.00
IUUC-Pca-100379	Procavia capensis	65.55	2.00e-163	569.00
IUUC-Rno-105396	Rattus norvegicus	85.17	0.00e+00	1354.00
IUUC-Sha-107216	Sarcophilus harrisii	82.20	0.00e+00	1344.00
IUUC-Ssc-116413	Sus scrofa	83.33	0.00e+00	1301.00
IUUC-Tgu-116723	Taeniopygia guttata	83.19	0.00e+00	1316.00
IUUC-Tru-117843	Takifugu rubripes	82.58	0.00e+00	1314.00
IUUC-Tsy-119455	Tarsius syrichta	81.91	0.00e+00	1233.00
IUUC-Tni-120037	Tetraodon nigroviridis	77.98	0.00e+00	1224.00
IUUC-Tbe-127879	Tupaia belangeri	70.41	0.00e+00	1070.00
IUUC-Ttr-128423	Tursiops truncatus	81.13	0.00e+00	1244.00
IUUC-Xtr-132237	Xenopus tropicalis	79.41	0.00e+00	1311.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence