iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034134

UUCD1 version

UUC-EqC-00222

Ensembl Protein ID

ENSECAP00000006726.1

UniProt Accession

F6TGD2; F6TGD2_HORSE

Protein Name

Uncharacterized protein

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000008712.1	ENSECAT00000008920.1	ENSECAP00000006726.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.30e-13	48.2	329	362
E3 adaptor/Cullin RING/SCF/F-box	9.00e-06	26.0	9	53
UBD/Beta-Prp	3.70e-43	147.9	98	401

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 6    vtclaf..sd.tllvsGsdDgtikvWDlrtgvll 36
            tc+++  s  +l+vsG+ D  +++ Dlrt++ +
   Q: 329  FTCVNLrdSPpNLMVSGNMDRRVRIHDLRTDKIT 362
           5899*9973359******************9876 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 102  lldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
              +lp+e+ ++i+++ld+++l+r+a+v+++w+ +a+++ lw ++
   Q: 9    FDIQLPYELAINIFQYLDRKDLGRCAQVSKTWKVIAEDEVLWYRL 53
           5679*****************************999999999765 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae.........vtavkfspdgkilvtgseDrtikvwdlst 83
           +l++ +++v+++v+   ++ ++++g+++g ++vwd++t+++++ + + e e         v+ v+++++  + v + eD+++++wdl+t
   Q: 98   ELEHIPDAVLCDVHS--HDGVVIAGYTSGDVRVWDTRTWDYIAPFLESEYEedepgmqpyVSFVRINSS--LAVAAYEDGFLNIWDLRT 182
           567778999998888..9***********************6666555544555679999*********..9***************** PP
   S: 84   gkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl 171
           gk+ ++  +h++++ +l++s+++ +++++s+ +++++   e+g++  + + + +++v ++++ pd+ ++ v+ ++ + + ++ lk ++ 
   Q: 183  GKYPIHRFEHDARIQALALSQEDATVATASAFDVVMLCPNEEGYWQIAAEFEVQKLVDYLEIVPDTgRYPVAVATAGDL-VYLLKAEDS 270
           *****9999**************************************9******************************9.5******** PP
   S: 172  lrtltgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsg 254
            rtl     ++v++l+++sn+     k+l ++ + +++ +++l++++c+ +l +    +++v++  +  +++vsg++D+ +ri+dlr++
   Q: 271  ARTLHYVYGQPVTCLDVSSNQaafgvKSLGWVYEGNKILVYSLEAERCLSKLGNALGDFTCVNLRdSPPNLMVSGNMDRRVRIHDLRTD 359
           ****999********************************************************9978899******************* PP
   S: 255  dllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           +++ +l+ h+  v++v++   +d+++v+g+e++ v +w++++n++
   Q: 360  KITLSLSAHQLGVSAVQM---DDWKIVSGGEEGLVSVWDYRMNQK 401
           **********99999999...********************9875 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

NEMDDVPFFD IQLPYELAIN IFQYLDRKDL GRCAQVSKTW KVIAEDEVLW YRLCQQEGHL 60
PESSISDYSC WKLILQECRA KEHMLRTNWK NRKGAVSELE HIPDAVLCDV HSHDGVVIAG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCAGAATG AAATGGATGA TGTGCCCTTC TTCGATATCC AACTGCCTTA CGAATTGGCA 60
ATCAATATAT TTCAGTATCT GGACAGGAAA GACCTAGGAA GGTGTGCACA GGTAAGCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	95.49	0.00e+00	976.00
IUUC-Apl-003239	Anas platyrhynchos	65.66	0.00e+00	702.00
IUUC-Aca-004756	Anolis carolinensis	62.32	5.00e-142	497.00
IUUC-Ame-011198	Astyanax mexicanus	55.11	7.00e-54	204.00
IUUC-Bta-012430	Bos taurus	55.91	2.00e-145	509.00
IUUC-Cja-019131	Callithrix jacchus	84.35	0.00e+00	859.00
IUUC-Cfa-021022	Canis familiaris	95.49	0.00e+00	980.00
IUUC-Cpo-021898	Cavia porcellus	92.28	0.00e+00	961.00
IUUC-Csa-023452	Chlorocebus sabaeus	87.20	0.00e+00	892.00
IUUC-Cho-024759	Choloepus hoffmanni	80.89	0.00e+00	814.00
IUUC-Dre-028123	Danio rerio	50.60	3.00e-150	525.00
IUUC-Dno-029045	Dasypus novemcinctus	95.40	0.00e+00	914.00
IUUC-Dor-030433	Dipodomys ordii	90.46	0.00e+00	780.00
IUUC-Ete-032465	Echinops telfairi	90.42	0.00e+00	783.00
IUUC-Eeu-035047	Erinaceus europaeus	83.91	0.00e+00	849.00
IUUC-Fca-036574	Felis catus	94.29	0.00e+00	962.00
IUUC-Fal-037665	Ficedula albicollis	62.83	0.00e+00	633.00
IUUC-Gmo-039137	Gadus morhua	46.33	4.00e-61	228.00
IUUC-Gga-040711	Gallus gallus	65.05	0.00e+00	686.00
IUUC-Gac-041675	Gasterosteus aculeatus	54.74	2.00e-59	221.00
IUUC-Ggo-045331	Gorilla gorilla	86.59	0.00e+00	889.00
IUUC-Hsa-046240	Homo sapiens	87.20	0.00e+00	897.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	93.70	0.00e+00	947.00
IUUC-Loc-052631	Lepisosteus oculatus	56.39	2.00e-172	598.00
IUUC-Laf-054127	Loxodonta africana	81.82	7.00e-66	242.00
IUUC-Mcc-055083	Macaca mulatta	87.40	0.00e+00	898.00
IUUC-Mga-060113	Meleagris gallopavo	65.05	0.00e+00	686.00
IUUC-Mmr-061780	Microcebus murinus	92.68	0.00e+00	955.00
IUUC-Mdo-063066	Monodelphis domestica	69.64	0.00e+00	741.00
IUUC-Mmu-063524	Mus musculus	86.99	0.00e+00	883.00
IUUC-Mpu-066913	Mustela putorius furo	94.67	0.00e+00	964.00
IUUC-Mlu-067924	Myotis lucifugus	94.51	0.00e+00	943.00
IUUC-Nle-069558	Nomascus leucogenys	87.15	0.00e+00	849.00
IUUC-Opr-070506	Ochotona princeps	90.22	0.00e+00	934.00
IUUC-Ont-071514	Oreochromis niloticus	49.60	6.00e-148	517.00
IUUC-Ocu-074477	Oryctolagus cuniculus	90.52	0.00e+00	930.00
IUUC-Ola-087416	Oryzias latipes	49.50	5.00e-146	511.00
IUUC-Oga-088643	Otolemur garnettii	93.90	0.00e+00	971.00
IUUC-Oar-090172	Ovis aries	92.68	0.00e+00	960.00
IUUC-Ptr-090870	Pan troglodytes	87.40	0.00e+00	899.00
IUUC-Pan-092017	Papio anubis	86.79	0.00e+00	890.00
IUUC-Psi-093794	Pelodiscus sinensis	66.87	0.00e+00	698.00
IUUC-Pfo-096192	Poecilia formosa	51.61	5.00e-151	527.00
IUUC-Pab-097882	Pongo abelii	86.59	0.00e+00	885.00
IUUC-Pca-100902	Procavia capensis	92.02	1.00e-133	470.00
IUUC-Pva-103139	Pteropus vampyrus	95.33	0.00e+00	980.00
IUUC-Rno-105798	Rattus norvegicus	86.59	0.00e+00	904.00
IUUC-Sha-106576	Sarcophilus harrisii	69.26	0.00e+00	724.00
IUUC-Ssc-115923	Sus scrofa	85.71	0.00e+00	884.00
IUUC-Tgu-116667	Taeniopygia guttata	58.93	1.00e-124	439.00
IUUC-Tru-118323	Takifugu rubripes	47.99	2.00e-141	495.00
IUUC-Tsy-118818	Tarsius syrichta	78.35	7.00e-112	397.00
IUUC-Tni-120438	Tetraodon nigroviridis	47.99	4.00e-135	474.00
IUUC-Tbe-127784	Tupaia belangeri	94.66	4.00e-114	404.00
IUUC-Ttr-128288	Tursiops truncatus	84.32	0.00e+00	845.00
IUUC-Vpa-130307	Vicugna pacos	90.09	0.00e+00	827.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence