iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	miRecords	RepTar
miRNAMap	SomamiR	miRcode	RAID2
LncRNADisease
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.00e-18	68.7	124	181

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ++e+v++lyd+ +++ ++L +kkG+++ +i  e+ +e W+++ ++  g+ G++P  +vekl
   Q: 124  NLEYVRTLYDFPGNDAEDLPFKKGEILVII--EKPEEQWWSA-RNKDGRVGMIPVPYVEKL 181
           5789**************************..88999***99.6**************997 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1 (PubMed:11443118). Interacts with DOCK2 and DOCK5 via its first SH3 domain (PubMed:12393632, PubMed:19004829). Interacts with phosphorylated CBLB and IRS4 (PubMed:10022120, PubMed:9614078).

Protein Sequence
(Fasta)

MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH 60
YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPM GSVSAPNLPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAGGGGGA GGTGGCTGCC GCTTCTCCCG CGTCCGCCAT TTTGTTGCTG TGGCTATTGG 60
GAACAAGCTG GGCAAAAGCA CCCCGGAGGC GCGACGCTCC TTCGAGTTCG GTGCCTCGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0045296--F:cadherin binding
GO:0003723--F:RNA binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:0004871--F:signal transducer activity
GO:0000186--P:activation of MAPKK activity
GO:0009887--P:animal organ morphogenesis
GO:0009952--P:anterior/posterior pattern specification
GO:0001568--P:blood vessel development
GO:0007507--P:heart development
GO:0035556--P:intracellular signal transduction
GO:0007254--P:JNK cascade
GO:0060017--P:parathyroid gland development
GO:0008284--P:positive regulation of cell proliferation
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:0007265--P:Ras protein signal transduction
GO:0048538--P:thymus development

KEGG

hsa:1399

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002025	Ailuropoda melanoleuca	97.93	8.00e-172	595.00
IUUC-Apl-004166	Anas platyrhynchos	89.07	5.00e-158	550.00
IUUC-Aca-004695	Anolis carolinensis	54.24	5.00e-84	303.00
IUUC-Ame-011285	Astyanax mexicanus	80.13	1.00e-138	485.00
IUUC-Bta-013076	Bos taurus	76.69	3.00e-112	398.00
IUUC-Cja-019850	Callithrix jacchus	99.31	1.00e-173	602.00
IUUC-Cfa-020428	Canis familiaris	97.24	2.00e-170	590.00
IUUC-Cpo-022079	Cavia porcellus	96.55	2.00e-169	587.00
IUUC-Csa-023877	Chlorocebus sabaeus	99.66	3.00e-174	603.00
IUUC-Cin-025128	Ciona intestinalis	50.78	6.00e-80	290.00
IUUC-Csv-026340	Ciona savignyi	47.93	7.00e-70	257.00
IUUC-Dre-027833	Danio rerio	80.68	5.00e-134	470.00
IUUC-Dno-029510	Dasypus novemcinctus	95.52	8.00e-169	585.00
IUUC-Dor-030297	Dipodomys ordii	97.03	1.00e-175	608.00
IUUC-Dme-031600	Drosophila melanogaster	44.08	2.00e-69	255.00
IUUC-Eca-033810	Equus caballus	97.93	3.00e-171	593.00
IUUC-Fca-036412	Felis catus	97.93	8.00e-172	595.00
IUUC-Fal-037170	Ficedula albicollis	90.69	2.00e-152	531.00
IUUC-Gga-040733	Gallus gallus	91.72	2.00e-141	494.00
IUUC-Gac-042398	Gasterosteus aculeatus	80.77	1.00e-144	505.00
IUUC-Ggo-044447	Gorilla gorilla	100.00	5.00e-117	412.00
IUUC-Itr-048092	Ictidomys tridecemlineatus	97.93	4.00e-171	593.00
IUUC-Kpa-049154	Komagataella pastoris	40.91	2.00e-10	60.10
IUUC-Lch-050385	Latimeria chalumnae	60.20	1.00e-99	356.00
IUUC-Loc-052916	Lepisosteus oculatus	84.92	9.00e-148	516.00
IUUC-Laf-053545	Loxodonta africana	97.00	8.00e-114	402.00
IUUC-Mga-059586	Meleagris gallopavo	93.10	6.00e-155	540.00
IUUC-Mvi-060518	Microbotryum violaceum	37.70	7.00e-11	61.20
IUUC-Mdo-061868	Monodelphis domestica	89.66	1.00e-158	552.00
IUUC-Mmu-063179	Mus musculus	96.55	4.00e-170	590.00
IUUC-Mpu-065863	Mustela putorius furo	97.93	1.00e-171	595.00
IUUC-Mlu-067290	Myotis lucifugus	96.90	3.00e-170	590.00
IUUC-Nle-069118	Nomascus leucogenys	100.00	2.00e-174	604.00
IUUC-Opr-070565	Ochotona princeps	95.38	5.00e-173	600.00
IUUC-Ont-071608	Oreochromis niloticus	81.47	9.00e-148	516.00
IUUC-Oan-072801	Ornithorhynchus anatinus	90.10	4.00e-164	570.00
IUUC-Ocu-073759	Oryctolagus cuniculus	97.24	3.00e-170	590.00
IUUC-Ola-086748	Oryzias latipes	76.32	4.00e-125	441.00
IUUC-Oga-088248	Otolemur garnettii	97.93	2.00e-171	594.00
IUUC-Oar-089525	Ovis aries	76.45	4.00e-122	430.00
IUUC-Ptr-091553	Pan troglodytes	100.00	2.00e-174	604.00
IUUC-Pan-092639	Papio anubis	100.00	2.00e-174	604.00
IUUC-Psi-093546	Pelodiscus sinensis	86.36	1.00e-100	358.00
IUUC-Pma-094340	Petromyzon marinus	59.68	2.00e-103	369.00
IUUC-Pfo-096090	Poecilia formosa	81.70	7.00e-148	516.00
IUUC-Pab-097876	Pongo abelii	99.57	3.00e-138	483.00
IUUC-Pca-100447	Procavia capensis	97.93	1.00e-171	595.00
IUUC-Pva-102346	Pteropus vampyrus	97.23	2.00e-169	587.00
IUUC-Rno-106017	Rattus norvegicus	96.55	5.00e-170	589.00
IUUC-Sha-106511	Sarcophilus harrisii	89.69	4.00e-103	367.00
IUUC-Sar-113583	Sorex araneus	96.90	1.00e-169	588.00
IUUC-Sre-115190	Sporisorium reilianum	30.00	2.00e-09	58.50
IUUC-Ssc-115339	Sus scrofa	95.52	3.00e-167	580.00
IUUC-Tgu-116454	Taeniopygia guttata	90.11	5.00e-97	346.00
IUUC-Tru-118580	Takifugu rubripes	78.14	2.00e-138	484.00
IUUC-Tsy-119327	Tarsius syrichta	95.53	3.00e-166	577.00
IUUC-Tni-120626	Tetraodon nigroviridis	77.88	8.00e-139	486.00
IUUC-Ttr-128248	Tursiops truncatus	96.90	2.00e-170	590.00
IUUC-Xtr-132626	Xenopus tropicalis	86.14	1.00e-151	529.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence