iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005109

UUCD1 version

UUC-AnC-00232

Ensembl Protein ID

ENSACAP00000014306.2

UniProt Accession

H9GL89; H9GL89_ANOCA

Protein Name

Uncharacterized protein

Gene Name

SOCS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000014599.2	ENSACAT00000014599.2	ENSACAP00000014306.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.20e-12	47.4	148	191

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 6    llrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
           l+ +++r+Lq+LCR++I+ + g+++l    +LPL+++LkdYL  +++
   Q: 148  LRKERVRPLQELCRRSIVAAAGKEGL---AQLPLNPVLKDYLAAFPF 191
           67899*********************...*************98876 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MVAHGGLTPE HGISSPPPPF AAHAAPRPAT PRDPRFQTFR SQEDFGAIAR TCALLEECGF 60
YWGPLPVSAA HERLRAEPVG TFLLRDSRQS NCFFAVSVRM AAGPTSVRVL FRGGRFSLDG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGGCAC ATGGTGGCCT GACGCCGGAG CATGGGATCT CCTCGCCTCC GCCGCCCTTT 60
GCGGCCCATG CGGCCCCCCG CCCGGCGACC CCCCGGGACC CCCGCTTCCA GACCTTCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0004860--F:protein kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0016567--P:protein ubiquitination
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

KEGG

acs:100560891

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	61.49	1.00e-53	202.00
IUUC-Apl-003313	Anas platyrhynchos	67.08	3.00e-64	237.00
IUUC-Ame-011550	Astyanax mexicanus	51.57	3.00e-48	184.00
IUUC-Bta-013411	Bos taurus	67.08	5.00e-63	233.00
IUUC-Cja-019595	Callithrix jacchus	67.70	2.00e-63	234.00
IUUC-Cfa-020563	Canis familiaris	68.32	2.00e-63	234.00
IUUC-Cpo-021374	Cavia porcellus	68.32	3.00e-64	237.00
IUUC-Csa-023333	Chlorocebus sabaeus	67.70	1.00e-63	235.00
IUUC-Dre-028507	Danio rerio	45.05	8.00e-46	176.00
IUUC-Dno-029406	Dasypus novemcinctus	67.70	4.00e-63	233.00
IUUC-Ete-032399	Echinops telfairi	66.46	5.00e-62	230.00
IUUC-Eca-033519	Equus caballus	65.84	9.00e-60	222.00
IUUC-Fal-036726	Ficedula albicollis	67.70	5.00e-65	239.00
IUUC-Gmo-039667	Gadus morhua	50.00	9.00e-25	106.00
IUUC-Gga-040970	Gallus gallus	68.35	5.00e-64	236.00
IUUC-Gac-041838	Gasterosteus aculeatus	48.12	8.00e-35	139.00
IUUC-Ggo-045569	Gorilla gorilla	59.59	2.00e-64	237.00
IUUC-Hsa-046010	Homo sapiens	67.70	1.00e-63	235.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	67.70	2.00e-63	234.00
IUUC-Lch-050219	Latimeria chalumnae	59.63	6.00e-57	213.00
IUUC-Loc-052494	Lepisosteus oculatus	54.72	7.00e-51	192.00
IUUC-Laf-054219	Loxodonta africana	69.12	6.00e-52	195.00
IUUC-Mcc-054830	Macaca mulatta	67.70	1.00e-63	235.00
IUUC-Meu-056565	Macropus eugenii	66.46	4.00e-64	236.00
IUUC-Mga-060153	Meleagris gallopavo	67.72	2.00e-63	234.00
IUUC-Mmr-061365	Microcebus murinus	67.70	2.00e-63	235.00
IUUC-Mdo-062824	Monodelphis domestica	59.57	5.00e-64	236.00
IUUC-Mmu-064120	Mus musculus	68.94	1.00e-64	238.00
IUUC-Mpu-066839	Mustela putorius furo	67.70	1.00e-63	235.00
IUUC-Mlu-067829	Myotis lucifugus	66.46	1.00e-62	232.00
IUUC-Nle-069592	Nomascus leucogenys	66.46	2.00e-61	228.00
IUUC-Ont-072173	Oreochromis niloticus	49.06	2.00e-37	148.00
IUUC-Oan-073586	Ornithorhynchus anatinus	48.11	5.00e-23	99.80
IUUC-Ocu-073996	Oryctolagus cuniculus	68.32	8.00e-64	235.00
IUUC-Ola-087158	Oryzias latipes	50.62	2.00e-39	154.00
IUUC-Oga-088076	Otolemur garnettii	67.70	9.00e-64	235.00
IUUC-Ptr-091241	Pan troglodytes	67.70	1.00e-63	235.00
IUUC-Pan-091836	Papio anubis	59.28	2.00e-64	237.00
IUUC-Psi-093628	Pelodiscus sinensis	68.32	3.00e-65	240.00
IUUC-Pfo-097501	Poecilia formosa	47.47	6.00e-36	143.00
IUUC-Pab-098170	Pongo abelii	67.70	2.00e-63	235.00
IUUC-Pva-102796	Pteropus vampyrus	67.08	7.00e-63	233.00
IUUC-Rno-105319	Rattus norvegicus	68.94	1.00e-64	238.00
IUUC-Sha-107201	Sarcophilus harrisii	67.10	4.00e-62	229.00
IUUC-Ssc-116004	Sus scrofa	67.70	2.00e-63	234.00
IUUC-Tgu-116836	Taeniopygia guttata	67.08	8.00e-64	236.00
IUUC-Tru-118090	Takifugu rubripes	47.80	4.00e-36	144.00
IUUC-Tni-120719	Tetraodon nigroviridis	46.54	3.00e-32	131.00
IUUC-Vpa-130235	Vicugna pacos	67.70	2.00e-63	234.00
IUUC-Xtr-132610	Xenopus tropicalis	58.39	5.00e-58	216.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence