iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000059923.13	ENSMUST00000106497.7	ENSMUSP00000102106.1
ENSMUSG00000059923.13	ENSMUST00000106499.7	ENSMUSP00000102108.1
ENSMUSG00000059923.13	ENSMUST00000106495.7	ENSMUSP00000102104.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.60e-36	125.1	157	214

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +  +vq+l+d+++q+d+eL +++Gd+++v+  ++ d +W+kg    +g+ G+fP n+v+ ++
   Q: 157  QPTYVQALFDFDPQEDGELGFRRGDFIHVM--DNSDPNWWKG--ACHGQTGMFPRNYVTPVN 214
           5689*************************9..9*********..8**************997 PP

Organism

Mus musculus

Functional Description
(View)

Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced. transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death (By similarity).

Protein Sequence
(Fasta)

MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW 60
FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGACCCTG GCGAGGAGCG GAAGCTAGGT TGCTCTGTTG CTTCTGCGAT CGGGCGGCGG 60
CGGCGGCGAG AGCGAGCGGG GCTGCGGCCG GGACGGCGGT CGGGGCAGCG GGCGCCGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005794--C:Golgi apparatus
GO:0070436--C:Grb2-EGFR complex
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0012506--C:vesicle membrane
GO:0046875--F:ephrin receptor binding
GO:0005154--F:epidermal growth factor receptor binding
GO:0042802--F:identical protein binding
GO:0043560--F:insulin receptor substrate binding
GO:0005168--F:neurotrophin TRKA receptor binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0019904--F:protein domain specific binding
GO:0019901--F:protein kinase binding
GO:0019903--F:protein phosphatase binding
GO:0003723--F:RNA binding
GO:0017124--F:SH3 domain binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:0007568--P:aging
GO:0048646--P:anatomical structure formation involved in morphogenesis
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0071479--P:cellular response to ionizing radiation
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0030838--P:positive regulation of actin filament polymerization
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0051291--P:protein heterooligomerization
GO:0007265--P:Ras protein signal transduction
GO:0031623--P:receptor internalization
GO:0042127--P:regulation of cell proliferation
GO:0043408--P:regulation of MAPK cascade
GO:0042770--P:signal transduction in response to DNA damage

KEGG

mmu:14784

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001345	Ailuropoda melanoleuca	98.96	5.00e-114	402.00
IUUC-Apl-003322	Anas platyrhynchos	96.86	1.00e-111	394.00
IUUC-Aca-005193	Anolis carolinensis	96.77	7.00e-127	446.00
IUUC-Ago-007965	Ashbya gossypii	48.15	1.00e-12	66.60
IUUC-Ame-010929	Astyanax mexicanus	90.78	3.00e-120	423.00
IUUC-Bta-012932	Bos taurus	99.54	3.00e-129	453.00
IUUC-Cel-018665	Caenorhabditis elegans	58.53	5.00e-72	263.00
IUUC-Cja-019225	Callithrix jacchus	99.54	3.00e-129	453.00
IUUC-Cfa-020887	Canis familiaris	99.54	3.00e-129	453.00
IUUC-Cpo-022488	Cavia porcellus	99.54	3.00e-129	453.00
IUUC-Csa-023326	Chlorocebus sabaeus	99.54	3.00e-129	453.00
IUUC-Cho-024953	Choloepus hoffmanni	81.57	1.00e-97	348.00
IUUC-Cin-025144	Ciona intestinalis	63.38	3.00e-74	271.00
IUUC-Csv-026210	Ciona savignyi	60.66	2.00e-71	261.00
IUUC-Dre-028403	Danio rerio	94.47	4.00e-124	436.00
IUUC-Dno-029187	Dasypus novemcinctus	98.16	4.00e-128	449.00
IUUC-Dor-030763	Dipodomys ordii	99.54	3.00e-129	453.00
IUUC-Dme-031741	Drosophila melanogaster	65.57	3.00e-78	284.00
IUUC-Ete-032354	Echinops telfairi	69.91	2.00e-82	298.00
IUUC-Eca-033222	Equus caballus	99.54	3.00e-129	453.00
IUUC-Eeu-034513	Erinaceus europaeus	73.73	3.00e-88	317.00
IUUC-Fca-036294	Felis catus	99.54	3.00e-129	453.00
IUUC-Fal-037130	Ficedula albicollis	96.31	2.00e-125	440.00
IUUC-Gmo-039546	Gadus morhua	93.09	1.00e-122	431.00
IUUC-Gga-041139	Gallus gallus	97.24	6.00e-127	446.00
IUUC-Gac-041968	Gasterosteus aculeatus	94.01	2.00e-123	434.00
IUUC-Ggo-044562	Gorilla gorilla	99.54	3.00e-129	453.00
IUUC-Hsa-046730	Homo sapiens	99.54	3.00e-129	453.00
IUUC-Itr-049025	Ictidomys tridecemlineatus	99.54	3.00e-129	453.00
IUUC-Lch-050230	Latimeria chalumnae	94.78	4.00e-73	268.00
IUUC-Loc-052723	Lepisosteus oculatus	95.39	4.00e-125	439.00
IUUC-Laf-053774	Loxodonta africana	98.16	4.00e-128	449.00
IUUC-Mcc-054603	Macaca mulatta	99.54	3.00e-129	453.00
IUUC-Meu-056173	Macropus eugenii	80.18	1.00e-99	355.00
IUUC-Mga-059950	Meleagris gallopavo	97.24	6.00e-127	446.00
IUUC-Mmr-060878	Microcebus murinus	99.54	3.00e-129	453.00
IUUC-Mdo-062454	Monodelphis domestica	97.24	6.00e-127	446.00
IUUC-Mpu-066125	Mustela putorius furo	99.54	3.00e-129	453.00
IUUC-Mlu-068007	Myotis lucifugus	99.54	3.00e-129	453.00
IUUC-Nle-069101	Nomascus leucogenys	99.54	3.00e-129	453.00
IUUC-Opr-071075	Ochotona princeps	99.54	3.00e-129	453.00
IUUC-Ont-072253	Oreochromis niloticus	90.78	8.00e-120	422.00
IUUC-Ocu-074583	Oryctolagus cuniculus	99.54	3.00e-129	453.00
IUUC-Ola-086586	Oryzias latipes	94.87	8.00e-86	310.00
IUUC-Oga-089047	Otolemur garnettii	99.54	3.00e-129	453.00
IUUC-Oar-089904	Ovis aries	92.20	5.00e-118	416.00
IUUC-Ptr-090678	Pan troglodytes	99.54	3.00e-129	453.00
IUUC-Pan-092090	Papio anubis	99.54	3.00e-129	453.00
IUUC-Psi-093765	Pelodiscus sinensis	96.77	2.00e-126	444.00
IUUC-Pma-094650	Petromyzon marinus	85.25	9.00e-112	395.00
IUUC-Pfo-096131	Poecilia formosa	94.01	2.00e-123	434.00
IUUC-Pab-098709	Pongo abelii	99.54	3.00e-129	453.00
IUUC-Pca-100581	Procavia capensis	98.43	4.00e-113	399.00
IUUC-Pva-103066	Pteropus vampyrus	99.54	3.00e-129	453.00
IUUC-Rno-105224	Rattus norvegicus	99.54	3.00e-129	453.00
IUUC-Sce-106302	Saccharomyces cerevisiae	51.85	1.00e-15	76.30
IUUC-Sha-107247	Sarcophilus harrisii	97.38	6.00e-112	395.00
IUUC-Sar-113277	Sorex araneus	83.87	2.00e-103	367.00
IUUC-Ssc-115478	Sus scrofa	99.54	3.00e-129	453.00
IUUC-Tgu-117479	Taeniopygia guttata	95.85	5.00e-125	439.00
IUUC-Tru-118451	Takifugu rubripes	84.72	3.00e-107	380.00
IUUC-Tsy-119029	Tarsius syrichta	93.12	4.00e-83	300.00
IUUC-Tbe-128097	Tupaia belangeri	99.08	2.00e-128	450.00
IUUC-Ttr-128871	Tursiops truncatus	99.36	9.00e-90	321.00
IUUC-Vpa-130754	Vicugna pacos	99.54	3.00e-129	453.00
IUUC-Xtr-132275	Xenopus tropicalis	91.27	8.00e-123	432.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence