iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dno-029832

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

DP001109

Gene Name

USP44; USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDNOG00000036608.1	ENSDNOT00000032809.1	ENSDNOP00000018754.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.10e-98	328.1	271	674

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp..................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+                    +                                     
   Q: 271  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnqwlavtA---------Sdktrsykhpavtdtiilmnecqekdigsvhsrypgls 350
           7******************************76655444431.........13345556678888999999999999999999999999 PP
   S: 43   .....................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkke 110
                                +++  +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld+++ el   
   Q: 351  sglsggalksrkmeliqprepSSQYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQHEL--- 436
           99999999888888888877777777************************************************************... PP
   S: 111  knkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcLe 192
                 e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +        ++++L+
   Q: 437  ------ETTGTRLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCSGKdipsqpcLVTEMLA 519
           ......7788888999999************************************************9999887789999999****** PP
   S: 193  sftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspee 270
           +ft++e leg+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++ 
   Q: 520  KFTETEALEGKI-YVCDHCNSKCRrfsskpvvlteAQKQLMICQLPQVLRLHLKRFRWSGR-NNREKIGVHVGFEEILTMEPYCCRESL 606
           *********965.*******999999999999999***********************998.7778********************998 PP
   S: 271  kqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           k+ +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev++   ++aY+lfY++
   Q: 607  KSLRpeCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSMCTMDEVCK---AQAYILFYTQ 674
           8876779***************************9999********************...********98 PP

Organism

Dasypus novemcinctus

Protein Sequence
(Fasta)

MLTMDKCKHV GQLQLAQDHS ILNPQKWHCV DCNTTESIWA CLSCSHVACG RYIEEHALKH 60
FQDSSHPVAL EVNEMYVFCY LCDDYVLNDN ATGDLKLLRS TLSAIKSQNY HCTTRSGRVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGCCGAGC GGCCGGGGCC CGCCGGGGCG CGGGGGTGGG GCCCGCCGCC GCGTCGCGAT 60
GACGTCACCG CCGGGCCGGG CCGCCGCCGC CGCCGCCGCC GCCGGACCGG GGGGCGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	92.41	0.00e+00	1336.00
IUUC-Apl-003673	Anas platyrhynchos	74.75	0.00e+00	1052.00
IUUC-Aca-004434	Anolis carolinensis	71.91	0.00e+00	1028.00
IUUC-Ame-010986	Astyanax mexicanus	63.53	0.00e+00	877.00
IUUC-Bta-012774	Bos taurus	89.17	0.00e+00	1275.00
IUUC-Cja-019619	Callithrix jacchus	89.47	0.00e+00	1276.00
IUUC-Cfa-020957	Canis familiaris	91.14	0.00e+00	1330.00
IUUC-Csa-023177	Chlorocebus sabaeus	90.32	0.00e+00	1284.00
IUUC-Cho-024877	Choloepus hoffmanni	91.79	0.00e+00	878.00
IUUC-Cin-025587	Ciona intestinalis	48.74	5.00e-107	382.00
IUUC-Csv-025814	Ciona savignyi	45.28	6.00e-154	537.00
IUUC-Dre-027878	Danio rerio	64.24	0.00e+00	845.00
IUUC-Ete-032627	Echinops telfairi	87.22	0.00e+00	1253.00
IUUC-Eca-033863	Equus caballus	85.33	0.00e+00	1209.00
IUUC-Eeu-035225	Erinaceus europaeus	84.95	0.00e+00	1202.00
IUUC-Fca-036288	Felis catus	91.84	0.00e+00	1327.00
IUUC-Fal-037207	Ficedula albicollis	74.64	0.00e+00	1015.00
IUUC-Gga-040457	Gallus gallus	73.10	0.00e+00	1016.00
IUUC-Ggo-044926	Gorilla gorilla	90.17	0.00e+00	1276.00
IUUC-Hsa-046079	Homo sapiens	90.03	0.00e+00	1276.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	91.42	0.00e+00	1296.00
IUUC-Lch-050260	Latimeria chalumnae	66.99	0.00e+00	929.00
IUUC-Loc-051981	Lepisosteus oculatus	76.69	0.00e+00	665.00
IUUC-Laf-054491	Loxodonta africana	89.83	0.00e+00	1224.00
IUUC-Mcc-055694	Macaca mulatta	90.18	0.00e+00	1280.00
IUUC-Mga-059523	Meleagris gallopavo	72.93	0.00e+00	1035.00
IUUC-Mmr-060885	Microcebus murinus	92.85	0.00e+00	1314.00
IUUC-Mdo-063018	Monodelphis domestica	79.60	0.00e+00	1114.00
IUUC-Mmu-064012	Mus musculus	79.89	0.00e+00	1095.00
IUUC-Mpu-066207	Mustela putorius furo	91.42	0.00e+00	1343.00
IUUC-Mlu-066929	Myotis lucifugus	87.65	0.00e+00	1189.00
IUUC-Nle-069313	Nomascus leucogenys	79.89	0.00e+00	1093.00
IUUC-Opr-070375	Ochotona princeps	81.32	0.00e+00	1120.00
IUUC-Ont-071637	Oreochromis niloticus	61.99	0.00e+00	852.00
IUUC-Oan-073030	Ornithorhynchus anatinus	77.59	0.00e+00	850.00
IUUC-Ocu-074836	Oryctolagus cuniculus	87.73	0.00e+00	1241.00
IUUC-Oga-088367	Otolemur garnettii	91.58	0.00e+00	1283.00
IUUC-Oar-089953	Ovis aries	91.01	0.00e+00	1317.00
IUUC-Ptr-090980	Pan troglodytes	90.03	0.00e+00	1279.00
IUUC-Pan-092748	Papio anubis	90.87	0.00e+00	1291.00
IUUC-Pab-098514	Pongo abelii	90.04	0.00e+00	1277.00
IUUC-Pva-102984	Pteropus vampyrus	90.86	0.00e+00	1268.00
IUUC-Rno-106019	Rattus norvegicus	79.69	0.00e+00	1137.00
IUUC-Sha-106965	Sarcophilus harrisii	78.51	0.00e+00	1108.00
IUUC-Ssc-115299	Sus scrofa	91.55	0.00e+00	1339.00
IUUC-Tgu-117160	Taeniopygia guttata	74.96	0.00e+00	1018.00
IUUC-Tru-118156	Takifugu rubripes	61.19	0.00e+00	836.00
IUUC-Tni-119733	Tetraodon nigroviridis	59.72	0.00e+00	839.00
IUUC-Tbe-128084	Tupaia belangeri	83.43	0.00e+00	1197.00
IUUC-Ttr-128928	Tursiops truncatus	92.12	0.00e+00	1329.00
IUUC-Vpa-130706	Vicugna pacos	91.83	0.00e+00	1325.00
IUUC-Xtr-132061	Xenopus tropicalis	70.88	0.00e+00	936.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence