iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050260

Ensembl Protein ID

ENSLACP00000002218.1

UniProt Accession

H2ZXU7; H2ZXU7_LATCH

Genbank Protein ID

ENSLACP00000002218

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AFYH01171650

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000001981.1	ENSLACT00000002236.1	ENSLACP00000002218.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.30e-90	301.4	277	688

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle......kkkeklneenp......................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++ +re++l+      +         +                                         
   Q: 277  TGLRNLGNTCYMNSILQVLSHLQMFRECFLQldlsqaQ---------Eilacaangkarslgkpssladlvsnskgknekkkepalfrr 356
           7******************************5554331.........223355567788888888999999999999999999999999 PP
   S: 43   .........................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleee 106
                                    ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++e
   Q: 357  pslsaglsggasqsrnmeliqpkepSSTHISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKVQQE 445
           999999999999999999999988888888*********************************************************** PP
   S: 107  lkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........sl 187
           l         ++ +++  +   +++ k  k+  ++++++F+gql sq++cl cdn+s++ epf+dlsl++p++ +++ +         l
   Q: 446  L---------KTAGTKYPAFVPISQIKLIKQVLNVVNTIFHGQLLSQVTCLVCDNKSNTVEPFWDLSLEFPERYHCNGKesasqnscLL 525
           *.........55667777778888999********************************************8888877788888999** PP
   S: 188  qdcLesftkeeelegenkyycekckkkqe..............aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           +++L++ft++e leg+  y c++c+++ +              a ++l l   P+v+++  k f++s + ++reki  +v+f + ++++
   Q: 526  TEMLAKFTETEALEGKI-YACDQCNNLIKkkkkkknqnlllvpAARRLLLIASPRVFVMPCKIFRWSGR-NHREKIGVHVSFDQIINME 612
           **************965.*******7777777888999****************************997.8889*************** PP
   S: 263  pfctspeekqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           p+c+++++ + +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++ eev++   ++aY+lfY++
   Q: 613  PYCCRESTRSLKpeCFIYDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLSMCTAEEVCK---AQAYILFYTQ 688
           *****9888776679***************************9999********************...********98 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

NMDKCKHVGR VRLAQDHSIL NPQKWHCVDC NTTDSMWACL SCSHVACGRY IEEHALKHFQ 60
ESKHPLALEV NELYVFCYLC DDYVLNDNAT GDLKLLRSTL SAIKSQNYEC TTRSGRTLRS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATATGGATA AATGCAAGCA TGTGGGACGG GTTCGGCTAG CACAGGATCA CTCAATCCTG 60
AACCCCCAGA AATGGCACTG CGTGGACTGC AATACAACCG ATTCTATGTG GGCATGCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	70.08	0.00e+00	993.00
IUUC-Apl-003673	Anas platyrhynchos	76.15	0.00e+00	1020.00
IUUC-Aca-004434	Anolis carolinensis	75.61	0.00e+00	1013.00
IUUC-Ame-010986	Astyanax mexicanus	64.88	0.00e+00	857.00
IUUC-Bta-012774	Bos taurus	68.35	0.00e+00	961.00
IUUC-Cja-019619	Callithrix jacchus	67.42	0.00e+00	942.00
IUUC-Cfa-020957	Canis familiaris	69.66	0.00e+00	983.00
IUUC-Csa-023177	Chlorocebus sabaeus	67.88	0.00e+00	940.00
IUUC-Cho-024877	Choloepus hoffmanni	68.67	0.00e+00	650.00
IUUC-Dre-027878	Danio rerio	66.67	0.00e+00	835.00
IUUC-Dno-029832	Dasypus novemcinctus	68.96	0.00e+00	977.00
IUUC-Ete-032627	Echinops telfairi	66.20	0.00e+00	926.00
IUUC-Eca-033863	Equus caballus	66.76	0.00e+00	922.00
IUUC-Eeu-035225	Erinaceus europaeus	66.15	0.00e+00	902.00
IUUC-Fca-036288	Felis catus	69.38	0.00e+00	984.00
IUUC-Fal-037207	Ficedula albicollis	75.25	0.00e+00	1001.00
IUUC-Gga-040457	Gallus gallus	75.07	0.00e+00	993.00
IUUC-Ggo-044926	Gorilla gorilla	68.30	0.00e+00	945.00
IUUC-Hsa-046079	Homo sapiens	67.98	0.00e+00	939.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	69.50	0.00e+00	955.00
IUUC-Loc-051981	Lepisosteus oculatus	70.22	0.00e+00	941.00
IUUC-Laf-054491	Loxodonta africana	69.08	0.00e+00	953.00
IUUC-Mcc-055694	Macaca mulatta	67.93	0.00e+00	940.00
IUUC-Mga-059523	Meleagris gallopavo	75.07	0.00e+00	1008.00
IUUC-Mmr-060885	Microcebus murinus	70.14	0.00e+00	978.00
IUUC-Mdo-063018	Monodelphis domestica	75.40	0.00e+00	1009.00
IUUC-Mmu-064012	Mus musculus	62.04	0.00e+00	868.00
IUUC-Mpu-066207	Mustela putorius furo	69.24	0.00e+00	981.00
IUUC-Mlu-066929	Myotis lucifugus	67.11	0.00e+00	911.00
IUUC-Opr-070375	Ochotona princeps	67.19	0.00e+00	908.00
IUUC-Ont-071637	Oreochromis niloticus	65.27	0.00e+00	868.00
IUUC-Oan-073030	Ornithorhynchus anatinus	73.98	0.00e+00	790.00
IUUC-Ocu-074836	Oryctolagus cuniculus	67.00	0.00e+00	920.00
IUUC-Oga-088367	Otolemur garnettii	69.47	0.00e+00	976.00
IUUC-Oar-089953	Ovis aries	69.33	0.00e+00	988.00
IUUC-Ptr-090980	Pan troglodytes	68.12	0.00e+00	942.00
IUUC-Pan-092748	Papio anubis	68.54	0.00e+00	948.00
IUUC-Pab-098514	Pongo abelii	68.72	0.00e+00	945.00
IUUC-Pva-102984	Pteropus vampyrus	68.78	0.00e+00	971.00
IUUC-Rno-106019	Rattus norvegicus	63.20	0.00e+00	883.00
IUUC-Sha-106965	Sarcophilus harrisii	75.72	0.00e+00	1006.00
IUUC-Ssc-115299	Sus scrofa	69.14	0.00e+00	981.00
IUUC-Tgu-117160	Taeniopygia guttata	74.49	0.00e+00	1005.00
IUUC-Tru-118156	Takifugu rubripes	66.00	0.00e+00	860.00
IUUC-Tni-119733	Tetraodon nigroviridis	64.74	0.00e+00	871.00
IUUC-Tbe-128084	Tupaia belangeri	65.27	0.00e+00	923.00
IUUC-Ttr-128928	Tursiops truncatus	69.97	0.00e+00	984.00
IUUC-Vpa-130706	Vicugna pacos	68.95	0.00e+00	974.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence