iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-035753

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02199872

Gene Name

USP28

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000004976.3	ENSFCAT00000004980.3	ENSFCAP00000004608.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.50e-58	196.8	144	633

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +GlkN+gNtC++ +v+Q+L+++pe+r+l+l+     +  e+++    ++++  ++++lq lf+ ++ s++k v+p++ l+ lk + ++ 
   Q: 144  VGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSyslpqNVLENCPSH-TEKRNIVFMQELQYLFALMMGSNRKFVDPSAALDLLKGAFRS- 230
           6******************************96555445555543.3678889******************************99987. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
            + +qqD++Ef++ lld le++++                     + +++ +k+++++++lF g++ ++ + +        +e+f +++
   Q: 231  PEEQQQDVSEFTHKLLDWLEDAFQL------------------AVNVNNPRNKSENPMVQLFYGTFLTEGVREGKPFC--NNETFGQYP 299
           799********************22..................23457899****************99998665555..5899***** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe  + e  ++    +  +   ++++  ++ +++klP+vL+++L+Rf+f+++ +++eki++k+efp+ + ++
   Q: 300  LQVNGYR-----NLDECLEGAMVEGDID----LLPSD--HSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYMD 377
           *******.....99****7666555555....55554..456778899***************************************** PP
   S: 263  pfcts.................................................................................... 267
           +++ +                                                                                    
   Q: 378  RYMYKskelirskrecirklkeeikvlqqkleryvkygsgparfplpdmlkyviefastkpasesstsqsdhvtlplssvhcpvsdlas 466
           **999888888888888888888888888888888888888888888888888888777777776666666666666666666666665 PP
   S: 268  .....peekqke............................................................................. 274
                +     e                                                                             
   Q: 467  kestsK-----Espsqdvegtfsspedslpkskamnkpftssrssmempahpaprtvtedeinfvktclqrwrseieqdiqdlkncias 550
           554440.....156666666666667777777777777888888888888888888888888888888888888888999999999999 PP
   S: 275  ...............kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                          ++ Y+L+av+vH+G+++ GHY+ay++n+ ++ Wl+++D +Vte+++ee ++++       +aY+l+Y 
   Q: 551  ttqtieqmycdpllrQVPYRLHAVLVHEGQANAGHYWAYIYNQPRQvWLKYNDISVTESSWEELERDSYgglrnVSAYCLMYI 633
           999999999*****9***************************99999*******************8879************6 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MSCQMLLNQL REITGIQDPS FLHEALKASN GDITQAVSLL TEERVKEPGQ DTVATEPSEV 60
EGRAASKEVL AKVIDLTHDN KDDLQAAIAL SLLESPNIQA DGRDLNRMRE AASAETKRSK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTTAGTA GTTAGGATTT CCACCAAACT GTTGAAAATG CAATTTCAGA TCGGGGGAGG 60
CACTGAGTTC TTAATACGCC GTCAGGAGCA GCTGGCTCGG GCTTAACCAA GTAGATTGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016604--C:nuclear body
GO:0043234--C:protein complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008283--P:cell proliferation
GO:0034644--P:cellular response to UV
GO:0000077--P:DNA damage checkpoint
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0016579--P:protein deubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0031647--P:regulation of protein stability
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	96.61	0.00e+00	2061.00
IUUC-Apl-004010	Anas platyrhynchos	69.28	0.00e+00	1461.00
IUUC-Aca-004741	Anolis carolinensis	59.89	0.00e+00	850.00
IUUC-Ang-009577	Aspergillus niger	34.43	2.00e-12	68.20
IUUC-Ate-010275	Aspergillus terreus	36.11	9.00e-12	66.20
IUUC-Bta-013377	Bos taurus	92.66	0.00e+00	1923.00
IUUC-Cja-019977	Callithrix jacchus	94.08	0.00e+00	1976.00
IUUC-Cfa-020378	Canis familiaris	88.77	0.00e+00	1959.00
IUUC-Cpo-021817	Cavia porcellus	90.04	0.00e+00	1925.00
IUUC-Csa-023446	Chlorocebus sabaeus	92.72	0.00e+00	1364.00
IUUC-Cho-024717	Choloepus hoffmanni	83.96	0.00e+00	1226.00
IUUC-Dre-028105	Danio rerio	56.98	0.00e+00	719.00
IUUC-Dno-029559	Dasypus novemcinctus	90.45	0.00e+00	1507.00
IUUC-Dor-030955	Dipodomys ordii	90.03	0.00e+00	1921.00
IUUC-Ete-032828	Echinops telfairi	82.51	0.00e+00	1176.00
IUUC-Eca-034300	Equus caballus	93.88	0.00e+00	1938.00
IUUC-Eeu-034458	Erinaceus europaeus	88.76	0.00e+00	1726.00
IUUC-Fal-037062	Ficedula albicollis	64.55	0.00e+00	891.00
IUUC-Gmo-039593	Gadus morhua	52.09	0.00e+00	1033.00
IUUC-Gga-040878	Gallus gallus	64.90	0.00e+00	1311.00
IUUC-Gac-041867	Gasterosteus aculeatus	55.43	0.00e+00	1121.00
IUUC-Ggo-045384	Gorilla gorilla	94.08	0.00e+00	1982.00
IUUC-Hsa-046277	Homo sapiens	94.26	0.00e+00	1989.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	85.99	0.00e+00	1157.00
IUUC-Lch-049692	Latimeria chalumnae	67.14	0.00e+00	1400.00
IUUC-Laf-053808	Loxodonta africana	87.14	0.00e+00	1815.00
IUUC-Mcc-055473	Macaca mulatta	92.72	0.00e+00	1363.00
IUUC-Meu-056416	Macropus eugenii	74.81	0.00e+00	1526.00
IUUC-Mla-058944	Melampsora laricipopulina	22.74	1.00e-09	59.70
IUUC-Mga-060011	Meleagris gallopavo	67.85	0.00e+00	1405.00
IUUC-Mmr-060720	Microcebus murinus	90.96	0.00e+00	1876.00
IUUC-Mdo-061955	Monodelphis domestica	85.05	0.00e+00	1290.00
IUUC-Mmu-063870	Mus musculus	87.12	0.00e+00	1863.00
IUUC-Mpu-066454	Mustela putorius furo	94.93	0.00e+00	1379.00
IUUC-Mlu-067487	Myotis lucifugus	88.25	0.00e+00	1866.00
IUUC-Nle-070044	Nomascus leucogenys	94.07	0.00e+00	1983.00
IUUC-Opr-070888	Ochotona princeps	96.75	4.00e-160	558.00
IUUC-Ont-072386	Oreochromis niloticus	56.85	0.00e+00	739.00
IUUC-Ocu-074523	Oryctolagus cuniculus	91.25	0.00e+00	1928.00
IUUC-Ola-086393	Oryzias latipes	54.49	0.00e+00	1112.00
IUUC-Oga-088618	Otolemur garnettii	91.91	0.00e+00	1935.00
IUUC-Oar-089848	Ovis aries	85.04	0.00e+00	1835.00
IUUC-Ptr-091630	Pan troglodytes	93.85	0.00e+00	1518.00
IUUC-Pan-092882	Papio anubis	90.76	0.00e+00	824.00
IUUC-Psi-093422	Pelodiscus sinensis	64.70	0.00e+00	1379.00
IUUC-Pma-094250	Petromyzon marinus	52.83	4.00e-74	270.00
IUUC-Pfo-096466	Poecilia formosa	57.72	0.00e+00	768.00
IUUC-Pab-098337	Pongo abelii	94.17	0.00e+00	1982.00
IUUC-Pca-100901	Procavia capensis	77.99	0.00e+00	1581.00
IUUC-Pva-102226	Pteropus vampyrus	88.51	0.00e+00	1741.00
IUUC-Rno-105735	Rattus norvegicus	84.80	0.00e+00	1886.00
IUUC-Sha-107489	Sarcophilus harrisii	87.70	0.00e+00	1872.00
IUUC-Ssl-108532	Sclerotinia sclerotiorum	35.80	1.00e-09	58.90
IUUC-Tgu-116609	Taeniopygia guttata	68.36	0.00e+00	1400.00
IUUC-Tru-117807	Takifugu rubripes	54.85	0.00e+00	1097.00
IUUC-Tsy-118971	Tarsius syrichta	87.11	0.00e+00	1241.00
IUUC-Tni-119983	Tetraodon nigroviridis	55.49	0.00e+00	1127.00
IUUC-Ttr-128887	Tursiops truncatus	88.05	0.00e+00	1813.00
IUUC-Uma-129338	Ustilago maydis	25.98	1.00e-13	72.80
IUUC-Vda-129742	Verticillium dahliae	24.17	9.00e-13	69.70
IUUC-Vpa-130614	Vicugna pacos	93.41	0.00e+00	1508.00
IUUC-Xtr-132436	Xenopus tropicalis	63.38	0.00e+00	1292.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence