iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C	95.95	3.00e-35	144.00	IUUC-Hsa-046617

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).

Protein Sequence
(Fasta)

MDSEVQRDGR ILDLIDDAWR EDKLPYEDVA IPLSELPEPE QDNGGTTESV KEQEMKWTDL 60
ALQGLHENVP PAGN 74

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Nucleotide Sequence
(Fasta)

GTGACCCAGA AGAAGGGCGG GGCCGGGAGG AAGCCGACGC GCGCGCAGTG GGTAAGGGTT 60
TTTCGCGCCC GCGGCCCGGG TTTCCGAGGG TGGCCAAGCG TTCGCCCTCG AACTCCGGCG 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR008401--Apc13p

Pfam

PF05839--Apc13p

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0070979--P:protein K11-linked ubiquitination

KEGG

mmu:69010

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002060	Ailuropoda melanoleuca	95.95	1.00e-36	144.00
IUUC-Apl-003793	Anas platyrhynchos	95.95	7.00e-37	144.00
IUUC-Ang-009807	Aspergillus niger	41.51	1.30e-01	30.80
IUUC-Ame-011473	Astyanax mexicanus	83.78	7.00e-33	131.00
IUUC-Bta-013245	Bos taurus	95.95	1.00e-36	144.00
IUUC-Bdi-014946	Brachypodium distachyon	28.33	2.40e-02	29.60
IUUC-Cja-019842	Callithrix jacchus	95.95	1.00e-36	144.00
IUUC-Cfa-020699	Canis familiaris	94.52	7.00e-36	141.00
IUUC-Cpo-021689	Cavia porcellus	95.95	1.00e-36	144.00
IUUC-Cre-022801	Chlamydomonas reinhardtii	38.60	5.00e-05	38.50
IUUC-Csa-024230	Chlorocebus sabaeus	95.95	1.00e-36	144.00
IUUC-Cho-024912	Choloepus hoffmanni	92.68	5.00e-17	78.60
IUUC-Dre-027502	Danio rerio	83.78	8.00e-33	130.00
IUUC-Dno-030028	Dasypus novemcinctus	94.59	3.00e-36	142.00
IUUC-Dme-032017	Drosophila melanogaster	47.69	2.00e-13	67.40
IUUC-Fca-036477	Felis catus	95.95	7.00e-37	144.00
IUUC-Gmo-038910	Gadus morhua	83.56	5.00e-32	128.00
IUUC-Gga-040341	Gallus gallus	94.59	1.00e-36	143.00
IUUC-Gac-041662	Gasterosteus aculeatus	82.43	4.00e-33	132.00
IUUC-Ggo-044981	Gorilla gorilla	95.95	1.00e-36	144.00
IUUC-Hsa-046617	Homo sapiens	95.95	1.00e-36	144.00
IUUC-Itr-048223	Ictidomys tridecemlineatus	95.95	7.00e-37	144.00
IUUC-Lch-049909	Latimeria chalumnae	85.14	3.00e-33	132.00
IUUC-Loc-052273	Lepisosteus oculatus	85.14	2.00e-33	133.00
IUUC-Laf-054010	Loxodonta africana	95.95	7.00e-37	144.00
IUUC-Mcc-055444	Macaca mulatta	95.95	1.00e-36	144.00
IUUC-Meu-056616	Macropus eugenii	95.95	3.00e-37	145.00
IUUC-Mor-056997	Magnaporthe oryzae	32.86	9.20e-02	28.90
IUUC-Mpo-057556	Magnaporthe poae	33.80	4.60e-02	29.60
IUUC-Mmr-061624	Microcebus murinus	95.95	1.00e-36	144.00
IUUC-Mdo-062411	Monodelphis domestica	95.95	3.00e-37	145.00
IUUC-Mlu-067784	Myotis lucifugus	97.30	2.00e-37	146.00
IUUC-Nle-069142	Nomascus leucogenys	95.95	1.00e-36	144.00
IUUC-Opr-070423	Ochotona princeps	90.24	4.00e-17	79.00
IUUC-Ont-072545	Oreochromis niloticus	83.78	2.00e-33	133.00
IUUC-Ocu-073965	Oryctolagus cuniculus	95.95	1.00e-36	146.00
IUUC-Ola-087398	Oryzias latipes	83.78	1.00e-33	134.00
IUUC-Olu-087731	Ostreococcus lucimarinus	39.02	2.90e-02	29.60
IUUC-Oga-088169	Otolemur garnettii	95.95	7.00e-37	144.00
IUUC-Oar-089282	Ovis aries	95.95	1.00e-36	144.00
IUUC-Ptr-090825	Pan troglodytes	95.95	1.00e-36	144.00
IUUC-Pan-092483	Papio anubis	95.95	1.00e-36	144.00
IUUC-Pma-094442	Petromyzon marinus	69.86	6.00e-26	108.00
IUUC-Ppa-095318	Physcomitrella patens	33.33	2.80e-02	29.60
IUUC-Pfo-097112	Poecilia formosa	83.78	1.00e-33	134.00
IUUC-Pab-097629	Pongo abelii	95.95	1.00e-36	144.00
IUUC-Pca-100124	Procavia capensis	95.95	1.00e-36	144.00
IUUC-Pva-103072	Pteropus vampyrus	95.95	1.00e-36	144.00
IUUC-Rno-105841	Rattus norvegicus	98.65	3.00e-38	149.00
IUUC-Sha-107152	Sarcophilus harrisii	95.95	3.00e-37	145.00
IUUC-Ssc-115839	Sus scrofa	87.84	3.00e-32	129.00
IUUC-Tru-117841	Takifugu rubripes	83.78	1.00e-33	133.00
IUUC-Tsy-119486	Tarsius syrichta	92.68	3.00e-17	79.00
IUUC-Tur-126739	Triticum urartu	37.50	7.00e-02	28.50
IUUC-Ttr-128740	Tursiops truncatus	97.56	2.00e-16	76.30
IUUC-Vpa-130292	Vicugna pacos	95.95	9.00e-37	144.00
IUUC-Xtr-132252	Xenopus tropicalis	86.49	1.00e-25	107.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence