iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037192

Ensembl Protein ID

ENSFALP00000014225.1

UniProt Accession

U3KGS1; U3KGS1_FICAL

Genbank Protein ID

ENSFALP00000014225

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01000490

Gene Name

VHL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000013632.1	ENSFALT00000014284.1	ENSFALP00000014225.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	25.96	1.60e-02	35.40	IUUC-Dme-031988
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	69.33	8.00e-55	210.00	IUUC-Hsa-046547

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

GGERAGAARP VLRSVNTREL SEVVFNNHSP RCVLPVWLDF EGQPRGYPVL QPRSGRVMRS 60
YRGHLWLFRD AGTNDGLLVN QQELFVAAPN VTKADITLPV FTLKERCLQV VRSLVSPLDY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG 60
GGGGAGCGGG CGGGCGCGGC CCGGCCCGTG CTGCGCTCTG TCAACACGCG GGAGCTCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR002714--VHL
IPR024048--VHL_alpha_dom
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom

Pfam

PF01847--VHL
PF17211--VHL_C

Gene Ontology

GO:0005929--C:cilium
GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0001525--P:angiogenesis
GO:0043534--P:blood vessel endothelial cell migration
GO:0061073--P:ciliary body morphogenesis
GO:0030198--P:extracellular matrix organization
GO:0048069--P:eye pigmentation
GO:0048877--P:homeostasis of number of retina cells
GO:0061072--P:iris morphogenesis
GO:0006582--P:melanin metabolic process
GO:0045602--P:negative regulation of endothelial cell differentiation
GO:0010629--P:negative regulation of gene expression
GO:1902072--P:negative regulation of hypoxia-inducible factor-1alpha signaling pathway
GO:0070244--P:negative regulation of thymocyte apoptotic process
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0003310--P:pancreatic A cell differentiation
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0010498--P:proteasomal protein catabolic process
GO:2001233--P:regulation of apoptotic signaling pathway
GO:1903827--P:regulation of cellular protein localization
GO:0003309--P:type B pancreatic cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002327	Ailuropoda melanoleuca	60.26	1.00e-43	169.00
IUUC-Apl-003580	Anas platyrhynchos	84.15	2.00e-36	142.00
IUUC-Aca-004492	Anolis carolinensis	70.63	1.00e-46	178.00
IUUC-Ame-011818	Astyanax mexicanus	46.48	1.00e-33	135.00
IUUC-Bta-013459	Bos taurus	69.03	2.00e-56	211.00
IUUC-Cel-018173	Caenorhabditis elegans	30.65	4.00e-04	37.40
IUUC-Cja-019826	Callithrix jacchus	68.92	2.00e-54	205.00
IUUC-Cfa-021280	Canis familiaris	65.38	3.00e-52	197.00
IUUC-Cpo-022544	Cavia porcellus	68.46	1.00e-54	205.00
IUUC-Cre-022809	Chlamydomonas reinhardtii	29.85	9.00e-02	31.20
IUUC-Csa-023644	Chlorocebus sabaeus	67.79	7.00e-54	202.00
IUUC-Cho-024479	Choloepus hoffmanni	43.41	2.00e-22	97.10
IUUC-Cin-025505	Ciona intestinalis	26.27	9.00e-06	42.70
IUUC-Cme-027232	Cyanidioschyzon merolae	32.86	1.00e-05	42.70
IUUC-Dre-028350	Danio rerio	42.94	4.00e-24	103.00
IUUC-Dno-029207	Dasypus novemcinctus	67.33	4.00e-32	130.00
IUUC-Dor-030912	Dipodomys ordii	46.58	7.00e-29	119.00
IUUC-Dme-031988	Drosophila melanogaster	25.96	2.00e-03	35.40
IUUC-Eca-034007	Equus caballus	70.00	2.00e-09	52.80
IUUC-Fca-036350	Felis catus	65.19	8.00e-52	196.00
IUUC-Gmo-038921	Gadus morhua	55.10	5.00e-39	153.00
IUUC-Gga-041016	Gallus gallus	79.73	9.00e-68	248.00
IUUC-Gac-042560	Gasterosteus aculeatus	48.92	5.00e-35	140.00
IUUC-Ggo-045419	Gorilla gorilla	69.86	2.00e-54	204.00
IUUC-Hsa-046547	Homo sapiens	69.86	2.00e-54	204.00
IUUC-Itr-048225	Ictidomys tridecemlineatus	67.74	2.00e-55	207.00
IUUC-Lch-050463	Latimeria chalumnae	54.93	3.00e-42	164.00
IUUC-Loc-052053	Lepisosteus oculatus	51.05	3.00e-38	150.00
IUUC-Laf-053893	Loxodonta africana	64.63	4.00e-56	209.00
IUUC-Mcc-055347	Macaca mulatta	55.64	5.00e-34	136.00
IUUC-Mdo-062169	Monodelphis domestica	58.51	3.00e-24	102.00
IUUC-Mmu-064366	Mus musculus	67.63	1.00e-50	191.00
IUUC-Mpu-066593	Mustela putorius furo	66.45	2.00e-53	201.00
IUUC-Mlu-066926	Myotis lucifugus	68.87	2.00e-54	205.00
IUUC-Nle-069724	Nomascus leucogenys	69.66	7.00e-54	202.00
IUUC-Opr-070679	Ochotona princeps	66.67	1.00e-52	198.00
IUUC-Ont-071332	Oreochromis niloticus	46.41	6.00e-36	142.00
IUUC-Ola-086869	Oryzias latipes	45.86	9.00e-34	135.00
IUUC-Oga-089124	Otolemur garnettii	67.52	1.00e-54	205.00
IUUC-Oar-089799	Ovis aries	70.10	6.00e-33	131.00
IUUC-Ptr-091186	Pan troglodytes	72.04	7.00e-33	132.00
IUUC-Pan-092150	Papio anubis	68.75	4.00e-53	200.00
IUUC-Psi-094039	Pelodiscus sinensis	61.74	3.00e-43	167.00
IUUC-Pma-094129	Petromyzon marinus	40.46	2.00e-22	98.20
IUUC-Pfo-096892	Poecilia formosa	43.87	8.00e-31	125.00
IUUC-Pab-097822	Pongo abelii	69.66	7.00e-54	202.00
IUUC-Pca-101058	Procavia capensis	68.24	1.00e-49	189.00
IUUC-Pva-102932	Pteropus vampyrus	67.74	4.00e-55	206.00
IUUC-Rno-105050	Rattus norvegicus	64.02	2.00e-55	207.00
IUUC-Sha-106738	Sarcophilus harrisii	71.43	1.00e-31	127.00
IUUC-Ssc-115973	Sus scrofa	67.74	9.00e-57	212.00
IUUC-Tgu-116663	Taeniopygia guttata	93.81	1.00e-49	187.00
IUUC-Tru-118654	Takifugu rubripes	52.52	3.00e-37	146.00
IUUC-Ttr-128418	Tursiops truncatus	68.39	4.00e-57	213.00
IUUC-Vpa-130268	Vicugna pacos	61.62	4.00e-28	117.00
IUUC-Xtr-132506	Xenopus tropicalis	54.32	2.00e-44	171.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence