iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106176

UUCD1 version

UUC-SaC-01071

Ensembl Protein ID

YNL186W

UniProt Accession

P53874; D6W101; UBP10_YEAST

Genbank Protein ID

CAA96080.1; DAA10367.2

Protein Name

Ubiquitin carboxyl-terminal hydrolase 10; Deubiquitinating enzyme 10; Disrupter of telomere silencing protein 4; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10

Genbank Nucleotide ID

Z71462; BK006947

Gene Name

UBP10; DOT4; YNL186W; N1619

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YNL186W	YNL186W	YNL186W

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	15721261; 20004458; 11352638

Classification

Family	E-value	Score	Start	End
DUB/USP	7.60e-75	250.6	363	732

Active Site

Position(s)	Description	Evidence
371	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10093}
691	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.........kskkkavsprellkalkkeaeefsgyeqqDaqE 94
           Gl N+g tCY N+++Q++++ip+++++l++    k +   ++ +k++++ +l++  +++w         + + ++++p++l++ l +++ ++s+ +q+D++E
   Q: 363  GLLNHGVTCYTNAAVQAMLHIPSIQHYLFDILMGKYD---STISKNSVSYTLAETSKKMWlpvsknprkNVSASYINPKHLISRLDDINCMMSEWQQEDSHE 461
           9*****************************4444433...3567789999999999999988865444444445**************************** PP
   S: 95   flaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........... 185
           +++ l+++l+e+                          k +k  +s+i d+F+g lk+ ++c++c+++s++e+pf+dlsl+++gk++ +++           
   Q: 462  YFMSLMSRLQEDS-----------------------VPKGHKLIESIIYDIFGGLLKQIVTCKSCGSISKTEQPFYDLSLHLKGKKKLDPNsdlssdsingt 540
           *************.......................45778999******************************************99998*********** PP
   S: 186  ............................................slqdcLesftkeeelegenk...yycekckkkqeaekklklkklPevLilhLkRfsfs 240
                                                       s+++++++f+++e ++ +++   y cekc+k ++a+k  ++ + Pe+L +hLk+f+f+
   Q: 541  sattstttsnaatkpslsssssvnlnngspfaaasdlssanrrfSIEKSIKDFFNPELIKVDKEqkgYVCEKCHKTTNAVKHSSILRAPETLLVHLKKFRFN 642
           *********************************************************9987766678********************************886 PP
   S: 241  eeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
               s++k+++ v++p  Ldl+++c+s+e     ++kY+L++vvvH+G slssGHY+a++k+ +g+W ++dD++++ ++e +vl+  + +aY l+Y+r
   Q: 643  G--TSSSKMKQAVSYPMFLDLTEYCESKEL----PVKYQLLSVVVHEGrSLSSGHYIAHCKQPDGSWATYDDEYINIISERDVLK--EPNAYYLLYTR 732
           6..6889*********99*********654....89*************************************************..59*******97 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Has a role in telomere and HM loci silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes.

Protein Sequence
(Fasta)

MTTQESIKPL VDRILSNPLQ FNAAMISNKS NNNDTSAAPE NSSYIVIGKQ HNNNSNSTAI 60
AATAESKQIK ENNLIDRPNG KKTNTVPKSM AEALLLYTSK NDKDAADATG AKKSAELSTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCACTC AAGAATCGAT CAAACCTTTG GTAGATAGAA TCCTATCAAA TCCCCTGCAG 60
TTCAATGCTG CAATGATCTC TAACAAATCG AATAATAATG ATACTTCCGC CGCGCCGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0779--Telomere
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006348--P:chromatin silencing at telomere
GO:0016578--P:histone deubiquitination
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

sce:YNL186W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001742	Ailuropoda melanoleuca	32.35	2.00e-26	112.00
IUUC-Apl-003351	Anas platyrhynchos	30.12	6.00e-26	110.00
IUUC-Ago-007836	Ashbya gossypii	66.91	2.00e-162	564.00
IUUC-Ate-010392	Aspergillus terreus	27.78	2.00e-14	72.40
IUUC-Bta-013132	Bos taurus	32.35	2.00e-26	112.00
IUUC-Cja-018811	Callithrix jacchus	32.35	3.00e-26	112.00
IUUC-Cfa-020761	Canis familiaris	33.33	9.00e-27	113.00
IUUC-Cpo-022267	Cavia porcellus	32.96	7.00e-27	114.00
IUUC-Csa-024251	Chlorocebus sabaeus	32.60	3.00e-26	112.00
IUUC-Cho-024483	Choloepus hoffmanni	39.42	9.00e-21	93.60
IUUC-Dre-028061	Danio rerio	32.97	7.00e-27	114.00
IUUC-Dno-029423	Dasypus novemcinctus	32.97	9.00e-27	113.00
IUUC-Dor-030877	Dipodomys ordii	32.59	7.00e-27	114.00
IUUC-Eca-034248	Equus caballus	32.35	4.00e-26	111.00
IUUC-Eeu-034620	Erinaceus europaeus	33.59	3.00e-24	105.00
IUUC-Fca-036357	Felis catus	32.60	9.00e-27	113.00
IUUC-Fal-037411	Ficedula albicollis	30.12	1.00e-25	110.00
IUUC-Gga-041101	Gallus gallus	30.12	4.00e-26	111.00
IUUC-Gac-041315	Gasterosteus aculeatus	30.80	6.00e-27	114.00
IUUC-Ggo-045600	Gorilla gorilla	31.29	8.00e-25	107.00
IUUC-Hsa-045825	Homo sapiens	32.96	4.00e-26	111.00
IUUC-Itr-049041	Ictidomys tridecemlineatus	32.35	3.00e-26	112.00
IUUC-Kpa-049198	Komagataella pastoris	52.78	1.00e-127	448.00
IUUC-Loc-052574	Lepisosteus oculatus	32.47	2.00e-26	112.00
IUUC-Laf-054428	Loxodonta africana	32.97	2.00e-26	112.00
IUUC-Mcc-055736	Macaca mulatta	32.60	3.00e-26	111.00
IUUC-Meu-056229	Macropus eugenii	38.52	1.00e-20	93.60
IUUC-Mga-059781	Meleagris gallopavo	30.50	2.00e-26	112.00
IUUC-Mdo-063048	Monodelphis domestica	30.50	3.00e-26	112.00
IUUC-Mmu-064079	Mus musculus	31.27	6.00e-25	107.00
IUUC-Mpu-066616	Mustela putorius furo	32.97	3.00e-27	115.00
IUUC-Mlu-067294	Myotis lucifugus	33.33	1.00e-26	113.00
IUUC-Nle-070015	Nomascus leucogenys	32.60	4.00e-26	111.00
IUUC-Opr-070606	Ochotona princeps	32.12	8.00e-26	110.00
IUUC-Ont-071464	Oreochromis niloticus	31.73	4.00e-26	111.00
IUUC-Ocu-074630	Oryctolagus cuniculus	32.97	8.00e-27	114.00
IUUC-Ola-087240	Oryzias latipes	31.00	3.00e-25	108.00
IUUC-Oga-088761	Otolemur garnettii	30.50	2.00e-26	112.00
IUUC-Ptr-091662	Pan troglodytes	32.60	3.00e-26	112.00
IUUC-Pan-092396	Papio anubis	32.35	3.00e-26	112.00
IUUC-Psi-093726	Pelodiscus sinensis	31.18	6.00e-26	110.00
IUUC-Pfo-096522	Poecilia formosa	31.25	4.00e-25	107.00
IUUC-Pab-098632	Pongo abelii	32.60	3.00e-26	111.00
IUUC-Pva-102820	Pteropus vampyrus	32.35	2.00e-26	112.00
IUUC-Rno-104894	Rattus norvegicus	31.62	4.00e-25	108.00
IUUC-Sha-107244	Sarcophilus harrisii	32.35	1.00e-25	110.00
IUUC-Tgu-117364	Taeniopygia guttata	29.73	1.00e-25	110.00
IUUC-Ttr-128732	Tursiops truncatus	31.79	2.00e-26	112.00
IUUC-Vpa-130598	Vicugna pacos	30.04	3.00e-23	102.00
IUUC-Xtr-132157	Xenopus tropicalis	31.85	2.00e-25	109.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence