iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021770

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02051332

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000008908.3	ENSCPOT00000008988.2	ENSCPOP00000008002.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-121	406.4	1235	1567

Active Site

Position(s)	Description	Evidence
1535	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1235 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1320
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1321 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1403
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1404 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRSNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1490
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1491 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1567
           **************************************************************************985 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MASSAREHLL FVRRRNPQMR YTLSPENLQS LAAQGSLPEN MTLPRANSDT DLVTSESRSS 60
LTASMYEYTL GQAQNLIIFW DIKEEVDPSD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTAGCT CGGCCCGGGA ACATCTGCTG TTTGTTCGGC GTCGGAACCC CCAGATGCGG 60
TACACACTGA GCCCCGAGAA CCTGCAGAGC CTGGCTGCTC AGGGCTCCCT GCCCGAGAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	89.77	0.00e+00	2745.00
IUUC-Apl-003935	Anas platyrhynchos	83.09	0.00e+00	2577.00
IUUC-Aca-004558	Anolis carolinensis	80.67	0.00e+00	2531.00
IUUC-Ame-010893	Astyanax mexicanus	88.31	0.00e+00	1305.00
IUUC-Bta-013093	Bos taurus	95.59	0.00e+00	1569.00
IUUC-Cja-019651	Callithrix jacchus	89.15	0.00e+00	2628.00
IUUC-Cfa-021232	Canis familiaris	98.11	0.00e+00	1611.00
IUUC-Csa-023970	Chlorocebus sabaeus	89.60	0.00e+00	2756.00
IUUC-Cho-024512	Choloepus hoffmanni	82.41	0.00e+00	2452.00
IUUC-Csv-026127	Ciona savignyi	72.27	5.00e-155	540.00
IUUC-Dre-028275	Danio rerio	85.12	0.00e+00	1475.00
IUUC-Dno-029963	Dasypus novemcinctus	88.82	0.00e+00	2593.00
IUUC-Dor-030282	Dipodomys ordii	82.58	0.00e+00	1782.00
IUUC-Dme-032217	Drosophila melanogaster	71.91	0.00e+00	657.00
IUUC-Ete-033132	Echinops telfairi	82.52	0.00e+00	1251.00
IUUC-Eca-033978	Equus caballus	89.47	0.00e+00	2746.00
IUUC-Eeu-035278	Erinaceus europaeus	62.80	0.00e+00	1143.00
IUUC-Fca-036157	Felis catus	90.03	0.00e+00	2730.00
IUUC-Fal-037110	Ficedula albicollis	96.78	0.00e+00	1607.00
IUUC-Gmo-039291	Gadus morhua	80.16	0.00e+00	1016.00
IUUC-Gga-040821	Gallus gallus	83.21	0.00e+00	2602.00
IUUC-Gac-042181	Gasterosteus aculeatus	88.32	0.00e+00	1421.00
IUUC-Ggo-044862	Gorilla gorilla	89.70	0.00e+00	2656.00
IUUC-Hsa-046219	Homo sapiens	89.86	0.00e+00	2798.00
IUUC-Lch-050526	Latimeria chalumnae	75.42	0.00e+00	2366.00
IUUC-Loc-052648	Lepisosteus oculatus	86.98	0.00e+00	1509.00
IUUC-Laf-054005	Loxodonta africana	89.78	0.00e+00	2729.00
IUUC-Mcc-055314	Macaca mulatta	89.47	0.00e+00	2747.00
IUUC-Meu-056356	Macropus eugenii	80.89	0.00e+00	794.00
IUUC-Mga-060074	Meleagris gallopavo	82.84	0.00e+00	2503.00
IUUC-Mmr-061526	Microcebus murinus	89.79	0.00e+00	2747.00
IUUC-Mdo-063017	Monodelphis domestica	87.36	0.00e+00	2667.00
IUUC-Mmu-064165	Mus musculus	89.60	0.00e+00	2735.00
IUUC-Mpu-065835	Mustela putorius furo	94.71	0.00e+00	1539.00
IUUC-Mlu-067709	Myotis lucifugus	85.53	0.00e+00	2635.00
IUUC-Nle-069308	Nomascus leucogenys	89.98	0.00e+00	2773.00
IUUC-Opr-070330	Ochotona princeps	78.89	0.00e+00	1944.00
IUUC-Ont-071345	Oreochromis niloticus	88.12	0.00e+00	1445.00
IUUC-Ocu-074775	Oryctolagus cuniculus	88.88	0.00e+00	2467.00
IUUC-Oga-088177	Otolemur garnettii	88.08	0.00e+00	2670.00
IUUC-Oar-089452	Ovis aries	89.60	0.00e+00	2724.00
IUUC-Ptr-090806	Pan troglodytes	89.82	0.00e+00	2775.00
IUUC-Pan-091838	Papio anubis	89.36	0.00e+00	2643.00
IUUC-Psi-094090	Pelodiscus sinensis	83.01	0.00e+00	2580.00
IUUC-Pfo-096520	Poecilia formosa	67.63	0.00e+00	1482.00
IUUC-Pab-098405	Pongo abelii	89.79	0.00e+00	2769.00
IUUC-Pca-100441	Procavia capensis	83.47	0.00e+00	2080.00
IUUC-Pva-102324	Pteropus vampyrus	97.73	0.00e+00	1606.00
IUUC-Rno-105943	Rattus norvegicus	89.29	0.00e+00	2812.00
IUUC-Sha-106985	Sarcophilus harrisii	83.75	0.00e+00	2222.00
IUUC-Sar-113505	Sorex araneus	94.44	0.00e+00	1523.00
IUUC-Ssc-115439	Sus scrofa	85.88	0.00e+00	1758.00
IUUC-Tgu-117078	Taeniopygia guttata	87.63	0.00e+00	1688.00
IUUC-Tru-118671	Takifugu rubripes	82.64	0.00e+00	1429.00
IUUC-Tsy-119498	Tarsius syrichta	97.49	0.00e+00	701.00
IUUC-Tni-120619	Tetraodon nigroviridis	87.36	0.00e+00	1419.00
IUUC-Tbe-127975	Tupaia belangeri	86.04	0.00e+00	2244.00
IUUC-Ttr-128469	Tursiops truncatus	83.87	0.00e+00	2464.00
IUUC-Vpa-130498	Vicugna pacos	80.52	0.00e+00	2274.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence