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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064123
Ensembl Protein ID ENSMUSP00000129739.1
UniProt Accession Q60902; Q3U7L9; Q3UIS9; Q8CB60; Q8CB70; Q91WH8; EP15R_MOUSE
Genbank Protein ID AAA87202.1; BAC29523.1; BAC29554.1; BAE27427.1; BAE31350.1; EDL10796.1; AAH15259.1
Protein Name Epidermal growth factor receptor substrate 15-like 1; Epidermal growth factor receptor pathway substrate 15-related sequence; Eps15-related protein
Genbank Nucleotide ID U29156; AK036662; AK036728; AK146781; AK152602; CH466525; BC015259
Gene Name Eps15l1; Eps15-rs; Eps15R
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000006276.10 ENSMUST00000163643.2 ENSMUSP00000129739.1
ENSMUSG00000006276.10 ENSMUST00000212121.1 ENSMUSP00000148468.1
ENSMUSG00000006276.10 ENSMUST00000212590.1 ENSMUSP00000148484.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 11919637
Classification
Family E-value Score Start End
UBD/Alpha-Helix/DUIM 0.22 12.9 889 904
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/DUIM
   S: 1    dEdeeLqlAlalSlqE 16
           +E+e+L+lA+alS+ +
   Q: 889  QEQEDLELAIALSKAD 904
           699**********876 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2 (By similarity).
 Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2 (By similarity).
Protein Sequence
(Fasta)
MAAPLVPLSQ QIPGGNPLYE SYYKQVDPAY TGRVGASEAA LFLKKSGLSD IILGKIWDLA 60
DPEGKGFLDK QGFYVALRLV ACAQSGHEVT LSSLSLTMPP PKFHDTSSPL MATQSSAETH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064123|UBD,UIM;UBD,DUIM|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCGGAGGCCG AGTCCGCACG AAGATGGCGG CGCCGCTTGT ACCCCTCTCG CAGCAGGTAT 60
GGTGCTGGGG TGCGCCGTGG GGCGGTGCGG ACGGTGGTTG CCGCGAGAAA GATAAGTCGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064123|UBD,UIM;UBD,DUIM|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0106--Calcium
KW-1003--Cell membrane
KW-0168--Coated pit
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0254--Endocytosis
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR027267--AH/BAR-dom
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR000261--EH_dom
IPR003903--UIM_dom
PROSITE

PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50031--EH
PS50330--UIM
Pfam

PF12763--EF-hand_4
SMART

SM00054--EFh
SM00027--EH
Gene Ontology

GO:0005913--C:cell-cell adherens junction
GO:0030132--C:clathrin coat of coated pit
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0098641--F:cadherin binding involved in cell-cell adhesion
GO:0005509--F:calcium ion binding
GO:0006897--P:endocytosis
KEGG mmu:13859
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002190 Ailuropoda melanoleuca 90.24 0.00e+00 1408.00
IUUC-Atr-002491 Amborella trichopoda 20.15 2.00e-13 72.00
IUUC-Apl-003895 Anas platyrhynchos 83.78 0.00e+00 1278.00
IUUC-Aly-006045 Arabidopsis lyrata 45.83 1.00e-13 72.80
IUUC-Ath-007330 Arabidopsis thaliana 43.90 8.00e-14 73.20
IUUC-Ago-007867 Ashbya gossypii 29.08 6.00e-30 126.00
IUUC-Afl-008603 Aspergillus flavus 32.14 6.00e-39 156.00
IUUC-Afu-008916 Aspergillus fumigatus 32.51 6.00e-41 163.00
IUUC-Ani-009469 Aspergillus nidulans 28.81 3.00e-38 154.00
IUUC-Aor-009997 Aspergillus oryzae 31.15 5.00e-36 147.00
IUUC-Ate-010517 Aspergillus terreus 30.68 2.00e-39 158.00
IUUC-Ame-011472 Astyanax mexicanus 69.38 0.00e+00 966.00
IUUC-Bgr-012135 Blumeria graminis 28.78 2.00e-37 151.00
IUUC-Bta-013308 Bos taurus 91.63 0.00e+00 1266.00
IUUC-Bci-013666 Botrytis cinerea 29.33 7.00e-40 159.00
IUUC-Cel-018526 Caenorhabditis elegans 29.22 9.00e-47 182.00
IUUC-Cja-019827 Callithrix jacchus 91.99 0.00e+00 1378.00
IUUC-Cfa-020227 Canis familiaris 90.38 0.00e+00 1406.00
IUUC-Cpo-021877 Cavia porcellus 82.88 0.00e+00 1180.00
IUUC-Csa-023659 Chlorocebus sabaeus 91.14 0.00e+00 1420.00
IUUC-Cin-025645 Ciona intestinalis 40.57 4.00e-109 389.00
IUUC-Cgl-026390 Colletotrichum gloeosporioides 23.71 1.00e-34 142.00
IUUC-Cne-027039 Cryptococcus neoformans 42.86 1.00e-14 76.60
IUUC-Dre-028630 Danio rerio 68.72 0.00e+00 981.00
IUUC-Dse-031409 Dothistroma septosporum 29.18 3.00e-37 151.00
IUUC-Dme-031851 Drosophila melanogaster 34.78 3.00e-59 224.00
IUUC-Ete-033018 Echinops telfairi 71.30 3.00e-123 436.00
IUUC-Eca-033480 Equus caballus 90.99 0.00e+00 1345.00
IUUC-Fca-035983 Felis catus 91.70 0.00e+00 1280.00
IUUC-Fal-037211 Ficedula albicollis 80.43 0.00e+00 1226.00
IUUC-Fox-037755 Fusarium oxysporum 31.79 1.00e-40 162.00
IUUC-Fso-038230 Fusarium solani 31.75 1.00e-42 168.00
IUUC-Gmo-039045 Gadus morhua 67.87 0.00e+00 894.00
IUUC-Ggr-039734 Gaeumannomyces graminis 31.72 3.00e-39 157.00
IUUC-Gga-040471 Gallus gallus 83.53 0.00e+00 1301.00
IUUC-Gac-041817 Gasterosteus aculeatus 68.83 0.00e+00 998.00
IUUC-Ggo-044868 Gorilla gorilla 90.53 0.00e+00 1328.00
IUUC-Hsa-045721 Homo sapiens 92.63 0.00e+00 1413.00
IUUC-Hvu-047143 Hordeum vulgare 23.45 1.00e-13 72.00
IUUC-Itr-048698 Ictidomys tridecemlineatus 94.14 6.00e-144 503.00
IUUC-Kpa-049396 Komagataella pastoris 30.93 1.00e-45 179.00
IUUC-Lch-049746 Latimeria chalumnae 74.92 0.00e+00 1174.00
IUUC-Loc-052757 Lepisosteus oculatus 73.96 0.00e+00 1113.00
IUUC-Lma-053198 Leptosphaeria maculans 30.03 9.00e-38 152.00
IUUC-Laf-054236 Loxodonta africana 78.81 0.00e+00 991.00
IUUC-Mcc-055213 Macaca mulatta 92.23 0.00e+00 1364.00
IUUC-Meu-056373 Macropus eugenii 72.97 0.00e+00 1047.00
IUUC-Mor-056953 Magnaporthe oryzae 33.80 2.00e-45 177.00
IUUC-Mpo-057429 Magnaporthe poae 38.68 7.00e-18 86.70
IUUC-Mla-059188 Melampsora laricipopulina 24.64 2.00e-35 145.00
IUUC-Mga-059308 Meleagris gallopavo 83.57 0.00e+00 1298.00
IUUC-Mvi-060354 Microbotryum violaceum 28.57 2.00e-38 155.00
IUUC-Mmr-061497 Microcebus murinus 92.09 0.00e+00 1424.00
IUUC-Mdo-063032 Monodelphis domestica 84.39 0.00e+00 1323.00
IUUC-Mpu-066896 Mustela putorius furo 91.50 0.00e+00 1235.00
IUUC-Mlu-067715 Myotis lucifugus 91.43 0.00e+00 1392.00
IUUC-Nfi-068419 Neosartorya fischeri 31.86 2.00e-39 158.00
IUUC-Ncr-068851 Neurospora crassa 27.87 4.00e-35 144.00
IUUC-Nle-069851 Nomascus leucogenys 89.12 0.00e+00 1330.00
IUUC-Opr-070476 Ochotona princeps 79.32 0.00e+00 1146.00
IUUC-Ont-071263 Oreochromis niloticus 68.18 0.00e+00 983.00
IUUC-Ocu-074170 Oryctolagus cuniculus 85.61 0.00e+00 1281.00
IUUC-Oba-075548 Oryza barthii 33.33 8.00e-13 69.70
IUUC-Obr-076871 Oryza brachyantha 41.67 1.00e-11 66.20
IUUC-Ogl-077317 Oryza glaberrima 33.33 8.00e-13 69.70
IUUC-Ogu-078266 Oryza glumaepatula 33.33 9.00e-13 69.70
IUUC-Oin-079539 Oryza indica 33.33 8.00e-13 70.10
IUUC-Ome-081550 Oryza meridionalis 33.33 7.00e-13 70.10
IUUC-Oni-082418 Oryza nivara 33.33 8.00e-13 70.10
IUUC-Opu-084149 Oryza punctata 43.06 2.00e-12 68.90
IUUC-Oru-084223 Oryza rufipogon 33.33 9.00e-13 69.70
IUUC-Osa-085387 Oryza sativa 33.33 7.00e-13 69.70
IUUC-Ola-086518 Oryzias latipes 66.43 0.00e+00 886.00
IUUC-Oga-088628 Otolemur garnettii 92.60 0.00e+00 1415.00
IUUC-Oar-089507 Ovis aries 89.79 0.00e+00 1328.00
IUUC-Ptr-091492 Pan troglodytes 89.98 0.00e+00 1324.00
IUUC-Pan-092868 Papio anubis 91.14 0.00e+00 1419.00
IUUC-Psi-093247 Pelodiscus sinensis 82.13 0.00e+00 1290.00
IUUC-Pma-094109 Petromyzon marinus 54.25 0.00e+00 721.00
IUUC-Pno-094814 Phaeosphaeria nodorum 28.73 2.00e-36 148.00
IUUC-Pfo-097520 Poecilia formosa 56.42 0.00e+00 633.00
IUUC-Pab-098751 Pongo abelii 92.52 0.00e+00 1412.00
IUUC-Pop-099501 Populus trichocarpa 36.36 2.00e-11 65.10
IUUC-Pca-100272 Procavia capensis 80.55 0.00e+00 686.00
IUUC-Ppe-101928 Prunus persica 42.47 3.00e-12 67.80
IUUC-Pva-102235 Pteropus vampyrus 84.92 0.00e+00 1178.00
IUUC-Pgr-103392 Puccinia graminis 28.20 4.00e-34 140.00
IUUC-Pte-104059 Pyrenophora teres 31.12 3.00e-24 108.00
IUUC-Pyt-104816 Pyrenophora triticirepentis 31.12 3.00e-24 108.00
IUUC-Rno-105454 Rattus norvegicus 98.13 0.00e+00 1478.00
IUUC-Sha-106549 Sarcophilus harrisii 82.87 0.00e+00 1313.00
IUUC-Sja-107675 Schizosaccharomyces japonicus 27.51 2.00e-34 141.00
IUUC-Spo-108370 Schizosaccharomyces pombe 29.86 3.00e-37 150.00
IUUC-Ssl-108463 Sclerotinia sclerotiorum 25.30 3.00e-37 150.00
IUUC-Smo-109013 Selaginella moellendorffii 42.39 5.00e-16 75.10
IUUC-Sit-110002 Setaria italica 20.70 3.00e-14 74.30
IUUC-Tgu-117217 Taeniopygia guttata 83.11 0.00e+00 1254.00
IUUC-Tru-117670 Takifugu rubripes 67.28 0.00e+00 989.00
IUUC-Tsy-119464 Tarsius syrichta 75.45 9.00e-153 533.00
IUUC-Tni-119871 Tetraodon nigroviridis 54.62 0.00e+00 761.00
IUUC-Tre-122064 Trichoderma reesei 29.64 1.00e-38 155.00
IUUC-Tvi-122351 Trichoderma virens 31.62 7.00e-42 166.00
IUUC-Tur-126672 Triticum urartu 23.77 1.00e-13 72.40
IUUC-Tme-126877 Tuber melanosporum 30.61 8.00e-43 169.00
IUUC-Ttr-129235 Tursiops truncatus 92.13 0.00e+00 1367.00
IUUC-Uma-129336 Ustilago maydis 32.46 5.00e-48 187.00
IUUC-Vda-129921 Verticillium dahliae 30.99 1.00e-37 152.00
IUUC-Vvi-130856 Vitis vinifera 41.10 2.00e-12 68.60
IUUC-Xtr-131940 Xenopus tropicalis 74.78 0.00e+00 1199.00
IUUC-Xma-134262 Xiphophorus maculatus 55.22 6.00e-105 375.00
IUUC-Yli-134577 Yarrowia lipolytica 28.04 2.00e-35 145.00
IUUC-Zma-134851 Zea mays 20.00 9.00e-13 69.70
Created Date 25-Jun-2017

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