iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048439

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01012768

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000016043.2	ENSSTOT00000016052.2	ENSSTOP00000014366.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.20e-122	408.6	1273	1605

Active Site

Position(s)	Description	Evidence
1573	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1273 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1358
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1359 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1441
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1442 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLR 1528
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1529 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYTMLYEKLLTAVEETSTFGLE 1605
           ************************999***********************************************985 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MLLHLCSVKN LYQNRFLGLA AMASPSRNSQ SRRRCKEPLR YSYNPDQFHN MDIRNGPHDG 60
VTIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIHW DIKEEVDAGD WIGMYLIDEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAACCTGCAC CCTGACGGGA GCATGATCTG TGCCCAGTCC GGGACTGCCA AGGTAAGAGA 60
GCGCTTTGCG GGGACTCTGC CTTCCGCCCC TGCCGCCCCC CCCCCGCCCT TCTCTGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	86.40	0.00e+00	2177.00
IUUC-Apl-003299	Anas platyrhynchos	80.48	0.00e+00	2439.00
IUUC-Aca-005024	Anolis carolinensis	79.25	0.00e+00	2410.00
IUUC-Ame-010893	Astyanax mexicanus	75.38	0.00e+00	1125.00
IUUC-Bta-012604	Bos taurus	90.66	0.00e+00	2642.00
IUUC-Cja-019880	Callithrix jacchus	86.47	0.00e+00	2258.00
IUUC-Cfa-021216	Canis familiaris	90.77	0.00e+00	1801.00
IUUC-Cpo-021466	Cavia porcellus	97.21	0.00e+00	1727.00
IUUC-Csa-023080	Chlorocebus sabaeus	93.05	0.00e+00	2753.00
IUUC-Cho-024740	Choloepus hoffmanni	81.68	0.00e+00	1197.00
IUUC-Csv-026127	Ciona savignyi	70.03	3.00e-149	521.00
IUUC-Dre-028750	Danio rerio	79.96	0.00e+00	1493.00
IUUC-Dno-030019	Dasypus novemcinctus	89.62	0.00e+00	2668.00
IUUC-Dor-031030	Dipodomys ordii	73.20	0.00e+00	1132.00
IUUC-Dme-032217	Drosophila melanogaster	69.52	0.00e+00	634.00
IUUC-Ete-032352	Echinops telfairi	93.85	0.00e+00	1255.00
IUUC-Eca-033948	Equus caballus	87.29	0.00e+00	2536.00
IUUC-Eeu-034474	Erinaceus europaeus	70.24	0.00e+00	833.00
IUUC-Fca-036148	Felis catus	90.62	0.00e+00	2649.00
IUUC-Fal-036957	Ficedula albicollis	87.05	0.00e+00	1771.00
IUUC-Gmo-038714	Gadus morhua	69.25	0.00e+00	1018.00
IUUC-Gga-041194	Gallus gallus	80.79	0.00e+00	2427.00
IUUC-Gac-041366	Gasterosteus aculeatus	78.06	0.00e+00	1379.00
IUUC-Ggo-045442	Gorilla gorilla	75.02	0.00e+00	1910.00
IUUC-Hsa-045730	Homo sapiens	93.11	0.00e+00	2751.00
IUUC-Lch-050185	Latimeria chalumnae	74.48	0.00e+00	1396.00
IUUC-Loc-052744	Lepisosteus oculatus	79.50	0.00e+00	1557.00
IUUC-Laf-054368	Loxodonta africana	98.32	0.00e+00	1501.00
IUUC-Mcc-055487	Macaca mulatta	92.86	0.00e+00	2761.00
IUUC-Meu-056751	Macropus eugenii	91.34	0.00e+00	728.00
IUUC-Mga-059545	Meleagris gallopavo	81.28	0.00e+00	2423.00
IUUC-Mmr-061078	Microcebus murinus	90.93	0.00e+00	2565.00
IUUC-Mdo-062176	Monodelphis domestica	84.87	0.00e+00	1717.00
IUUC-Mmu-063513	Mus musculus	89.25	0.00e+00	2610.00
IUUC-Mpu-065786	Mustela putorius furo	90.19	0.00e+00	2634.00
IUUC-Mlu-067780	Myotis lucifugus	83.27	0.00e+00	2345.00
IUUC-Nle-069213	Nomascus leucogenys	92.24	0.00e+00	2697.00
IUUC-Opr-070208	Ochotona princeps	97.18	0.00e+00	1492.00
IUUC-Ont-072132	Oreochromis niloticus	77.55	0.00e+00	1368.00
IUUC-Oan-072807	Ornithorhynchus anatinus	87.66	0.00e+00	1796.00
IUUC-Ocu-074745	Oryctolagus cuniculus	89.03	0.00e+00	2559.00
IUUC-Ola-086981	Oryzias latipes	73.52	0.00e+00	1494.00
IUUC-Oga-087965	Otolemur garnettii	90.30	0.00e+00	2551.00
IUUC-Oar-089749	Ovis aries	90.75	0.00e+00	1867.00
IUUC-Ptr-091243	Pan troglodytes	92.92	0.00e+00	2744.00
IUUC-Pan-092201	Papio anubis	91.72	0.00e+00	2731.00
IUUC-Psi-093511	Pelodiscus sinensis	83.73	0.00e+00	1722.00
IUUC-Pfo-097001	Poecilia formosa	71.51	0.00e+00	1451.00
IUUC-Pab-098728	Pongo abelii	90.14	0.00e+00	2636.00
IUUC-Pca-100129	Procavia capensis	81.71	0.00e+00	1256.00
IUUC-Pva-102250	Pteropus vampyrus	77.86	0.00e+00	2165.00
IUUC-Rno-105031	Rattus norvegicus	88.92	0.00e+00	2635.00
IUUC-Sha-106985	Sarcophilus harrisii	62.01	0.00e+00	1196.00
IUUC-Sar-113505	Sorex araneus	74.09	0.00e+00	1184.00
IUUC-Ssc-115534	Sus scrofa	88.95	0.00e+00	679.00
IUUC-Tgu-117515	Taeniopygia guttata	81.67	0.00e+00	2421.00
IUUC-Tru-117914	Takifugu rubripes	76.26	0.00e+00	1388.00
IUUC-Tsy-119379	Tarsius syrichta	79.17	0.00e+00	791.00
IUUC-Tni-120178	Tetraodon nigroviridis	76.49	0.00e+00	1401.00
IUUC-Tbe-127762	Tupaia belangeri	83.93	0.00e+00	1980.00
IUUC-Ttr-128806	Tursiops truncatus	93.17	0.00e+00	1735.00
IUUC-Vpa-130498	Vicugna pacos	62.12	0.00e+00	910.00
IUUC-Xtr-132903	Xenopus tropicalis	75.30	0.00e+00	1856.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence