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Tag Content
iUUCD ID IUUC-Oar-090265
Ensembl Protein ID ENSOARP00000004111.1
UniProt Accession W5P112; W5P112_SHEEP
Genbank Protein ID ENSOARP00000004111
Protein Name Histone-lysine N-methyltransferase
Genbank Nucleotide ID AMGL01092439
Gene Name NSD1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOARG00000003834.1 ENSOART00000004180.1 ENSOARP00000004108.1
ENSOARG00000003834.1 ENSOART00000004183.1 ENSOARP00000004111.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 1.90e-14 53.7 1712 1752
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC egg+    l++C+ C  +fH +Cl++      p+ + w+C++C+
   Q: 1712 WCFVCSEGGS----LLCCDSCPAAFHRECLNID----IPEGN-WYCNDCK 1752
           8*********....*******************....99996.******8 PP
   
Organism Ovis aries
Protein Sequence
(Fasta)
MDQTCKLPRR NCLLPFSNPV NLDAPEDKDS PFGNGQSNFS EPLNGCTMQL STASGTSQNA 60
YGQDSPSCYI PLRKLQDLAS MINVEYLNGS ADGSESFQDP EKSDSRAQSP VVCTSLNPGG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Oar-090265|E3,PHD|Ovis aries
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTGATGCTG GCCCAGGATG GATCAGACCT GTAAACTACC TAGAAGAAAT TGTCTGCTGC 60
CCTTTTCCAA TCCAGTGAAT TTAGATGCCC CTGAAGACAA GGACAGCCCT TTCGGTAATG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Oar-090265|E3,PHD|Ovis aries
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00855--PWWP
PF00856--SET
SMART

SM00570--AWS
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET
Gene Ontology

GO:0005634--C:nucleus
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0008270--F:zinc ion binding
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000414--P:regulation of histone H3-K36 methylation
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1903025--P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding
KEGG oas:101120917
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000310 Aegilops tauschii 29.53 7.00e-12 65.90
IUUC-Aml-001795 Ailuropoda melanoleuca 93.19 0.00e+00 4866.00
IUUC-Apl-003953 Anas platyrhynchos 56.94 0.00e+00 2237.00
IUUC-Aca-005339 Anolis carolinensis 50.86 0.00e+00 1757.00
IUUC-Ame-011932 Astyanax mexicanus 62.61 0.00e+00 923.00
IUUC-Bta-012966 Bos taurus 98.26 0.00e+00 5208.00
IUUC-Bdi-014781 Brachypodium distachyon 30.10 2.00e-13 71.20
IUUC-Bol-016001 Brassica oleracea 29.69 4.00e-17 84.30
IUUC-Bra-017864 Brassica rapa 29.17 5.00e-16 80.90
IUUC-Cja-018780 Callithrix jacchus 89.20 0.00e+00 4406.00
IUUC-Cfa-020975 Canis familiaris 92.41 0.00e+00 4872.00
IUUC-Cpo-021331 Cavia porcellus 87.68 0.00e+00 2683.00
IUUC-Csa-024226 Chlorocebus sabaeus 90.02 0.00e+00 4165.00
IUUC-Cho-024464 Choloepus hoffmanni 76.05 0.00e+00 1399.00
IUUC-Csv-026298 Ciona savignyi 38.54 4.00e-57 215.00
IUUC-Dre-028152 Danio rerio 62.89 0.00e+00 1251.00
IUUC-Dno-029230 Dasypus novemcinctus 87.69 0.00e+00 4521.00
IUUC-Dor-031016 Dipodomys ordii 81.18 0.00e+00 1320.00
IUUC-Dme-032193 Drosophila melanogaster 36.87 7.00e-123 435.00
IUUC-Eca-033591 Equus caballus 92.22 0.00e+00 4311.00
IUUC-Fca-035791 Felis catus 93.00 0.00e+00 5001.00
IUUC-Fal-037378 Ficedula albicollis 57.95 0.00e+00 2052.00
IUUC-Gmo-038919 Gadus morhua 71.20 0.00e+00 935.00
IUUC-Gga-040881 Gallus gallus 58.02 0.00e+00 2155.00
IUUC-Gac-041378 Gasterosteus aculeatus 77.87 0.00e+00 1071.00
IUUC-Hsa-046436 Homo sapiens 90.71 0.00e+00 4738.00
IUUC-Itr-048194 Ictidomys tridecemlineatus 88.70 0.00e+00 4198.00
IUUC-Lch-049684 Latimeria chalumnae 56.09 0.00e+00 1433.00
IUUC-Loc-052766 Lepisosteus oculatus 66.37 0.00e+00 993.00
IUUC-Laf-054046 Loxodonta africana 89.92 0.00e+00 4121.00
IUUC-Mcc-055593 Macaca mulatta 90.16 0.00e+00 4685.00
IUUC-Mga-059756 Meleagris gallopavo 57.12 0.00e+00 2224.00
IUUC-Mmr-061182 Microcebus murinus 89.45 0.00e+00 4759.00
IUUC-Mdo-061984 Monodelphis domestica 68.92 0.00e+00 3068.00
IUUC-Mmu-063605 Mus musculus 82.58 0.00e+00 4293.00
IUUC-Mpu-066446 Mustela putorius furo 92.45 0.00e+00 4923.00
IUUC-Mlu-067261 Myotis lucifugus 90.75 0.00e+00 4744.00
IUUC-Nle-069818 Nomascus leucogenys 90.18 0.00e+00 4199.00
IUUC-Opr-070842 Ochotona princeps 84.21 0.00e+00 2378.00
IUUC-Ont-072448 Oreochromis niloticus 75.67 0.00e+00 1149.00
IUUC-Oan-073496 Ornithorhynchus anatinus 76.24 0.00e+00 1645.00
IUUC-Ocu-074918 Oryctolagus cuniculus 89.19 0.00e+00 4733.00
IUUC-Obr-076753 Oryza brachyantha 54.84 9.00e-08 53.50
IUUC-Ogu-078898 Oryza glumaepatula 28.90 1.00e-09 57.40
IUUC-Oin-079557 Oryza indica 28.90 1.00e-09 57.40
IUUC-Osa-085353 Oryza sativa 28.90 8.00e-10 57.80
IUUC-Ola-087518 Oryzias latipes 76.70 0.00e+00 1056.00
IUUC-Oga-088743 Otolemur garnettii 87.93 0.00e+00 4017.00
IUUC-Ptr-090521 Pan troglodytes 90.67 0.00e+00 4739.00
IUUC-Psi-093245 Pelodiscus sinensis 59.21 0.00e+00 2041.00
IUUC-Pfo-096066 Poecilia formosa 62.28 0.00e+00 1216.00
IUUC-Pab-098644 Pongo abelii 90.06 0.00e+00 4169.00
IUUC-Pva-103094 Pteropus vampyrus 88.51 0.00e+00 2691.00
IUUC-Rno-105803 Rattus norvegicus 82.05 0.00e+00 3773.00
IUUC-Sha-107278 Sarcophilus harrisii 70.01 0.00e+00 3496.00
IUUC-Sar-113402 Sorex araneus 76.78 0.00e+00 2628.00
IUUC-Sbi-114400 Sorghum bicolor 36.54 3.00e-13 67.40
IUUC-Ssc-116193 Sus scrofa 93.19 0.00e+00 4250.00
IUUC-Tgu-116532 Taeniopygia guttata 89.85 0.00e+00 1253.00
IUUC-Tru-117988 Takifugu rubripes 77.86 0.00e+00 1201.00
IUUC-Tsy-118830 Tarsius syrichta 88.84 0.00e+00 3753.00
IUUC-Tni-120452 Tetraodon nigroviridis 64.04 0.00e+00 932.00
IUUC-Tca-121456 Theobroma cacao 30.33 2.00e-19 91.30
IUUC-Tae-124687 Triticum aestivum 29.53 8.00e-12 65.90
IUUC-Xma-133606 Xiphophorus maculatus 77.10 0.00e+00 1142.00
Created Date 25-Jun-2017

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