iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000010287.1	ENSPSIT00000011738.1	ENSPSIP00000011681.1
ENSPSIG00000010287.1	ENSPSIT00000011751.1	ENSPSIP00000011694.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-135	452.2	641	972

Active Site

Position(s)	Description	Evidence
942	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 641  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 729
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i VtneNk+eY++lv++
   Q: 730  FFIRPFYKMMLGKQITLKDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEITVTNENKREYIDLVIQ 813
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++t yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 814  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHTIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 902
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 903  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 972
           *********************************************************************8 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MANGAVEPVY GLSEDEDESR LLRVKVVSGI DLAKKDIFGA SDPYVKLSLY VADENRELAL 60
VQTKTIKKTL NPKWNEEFYF RVNPTNHRLL FEVFDENRLT RDDFLGQVDV PLNHLPTEDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGAACG GGGCGGTGGA GCCGGTCTAT GGACTTTCTG AAGACGAAGT AAGTCGCTCG 60
GGCTTGTGAC ACTTTTATTC CCGCCCCCCC CCTCCTAGCC CCTTTCCCGG CTGCGGACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	92.14	0.00e+00	1646.00
IUUC-Apl-003893	Anas platyrhynchos	95.54	0.00e+00	1728.00
IUUC-Aca-004744	Anolis carolinensis	91.36	0.00e+00	1674.00
IUUC-Ago-007742	Ashbya gossypii	48.48	6.00e-162	564.00
IUUC-Acl-008273	Aspergillus clavatus	48.85	1.00e-163	570.00
IUUC-Afl-008713	Aspergillus flavus	48.51	5.00e-160	557.00
IUUC-Afu-009103	Aspergillus fumigatus	48.85	6.00e-164	570.00
IUUC-Ani-009259	Aspergillus nidulans	48.03	3.00e-161	562.00
IUUC-Ang-009738	Aspergillus niger	48.83	3.00e-161	561.00
IUUC-Aor-010053	Aspergillus oryzae	58.39	3.00e-102	364.00
IUUC-Ate-010529	Aspergillus terreus	49.09	4.00e-163	568.00
IUUC-Ame-010810	Astyanax mexicanus	71.38	0.00e+00	1248.00
IUUC-Bgr-012148	Blumeria graminis	47.58	2.00e-153	535.00
IUUC-Bta-012679	Bos taurus	94.08	0.00e+00	1564.00
IUUC-Bci-013785	Botrytis cinerea	47.07	8.00e-156	543.00
IUUC-Cel-018564	Caenorhabditis elegans	53.34	0.00e+00	634.00
IUUC-Cja-018732	Callithrix jacchus	94.17	0.00e+00	1779.00
IUUC-Cfa-021226	Canis familiaris	93.75	0.00e+00	1737.00
IUUC-Cpo-021671	Cavia porcellus	92.19	0.00e+00	1690.00
IUUC-Csa-023344	Chlorocebus sabaeus	92.45	0.00e+00	1766.00
IUUC-Cho-024832	Choloepus hoffmanni	98.30	0.00e+00	735.00
IUUC-Csv-026098	Ciona savignyi	58.90	0.00e+00	654.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	48.00	3.00e-156	545.00
IUUC-Cne-026849	Cryptococcus neoformans	46.74	5.00e-159	554.00
IUUC-Dre-027770	Danio rerio	78.39	0.00e+00	1437.00
IUUC-Dno-029466	Dasypus novemcinctus	93.85	0.00e+00	1778.00
IUUC-Dor-030138	Dipodomys ordii	88.76	0.00e+00	1586.00
IUUC-Dse-031241	Dothistroma septosporum	47.53	1.00e-159	556.00
IUUC-Ete-033145	Echinops telfairi	85.96	0.00e+00	1249.00
IUUC-Eca-033445	Equus caballus	94.41	0.00e+00	1548.00
IUUC-Eeu-035247	Erinaceus europaeus	85.91	0.00e+00	1457.00
IUUC-Fca-035489	Felis catus	91.52	0.00e+00	1501.00
IUUC-Fal-037604	Ficedula albicollis	91.89	0.00e+00	1728.00
IUUC-Fox-037774	Fusarium oxysporum	48.76	7.00e-159	553.00
IUUC-Fso-038393	Fusarium solani	46.98	2.00e-154	538.00
IUUC-Gmo-039674	Gadus morhua	76.69	0.00e+00	1390.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.09	2.00e-156	546.00
IUUC-Gga-040703	Gallus gallus	94.26	0.00e+00	1778.00
IUUC-Gac-042020	Gasterosteus aculeatus	79.86	0.00e+00	1429.00
IUUC-Ggo-045332	Gorilla gorilla	92.74	0.00e+00	1683.00
IUUC-Hsa-045968	Homo sapiens	94.26	0.00e+00	1780.00
IUUC-Kpa-049273	Komagataella pastoris	48.99	3.00e-163	568.00
IUUC-Lch-050443	Latimeria chalumnae	86.93	0.00e+00	1454.00
IUUC-Lpe-050915	Leersia perrieri	44.58	4.00e-92	334.00
IUUC-Loc-052662	Lepisosteus oculatus	80.72	0.00e+00	1469.00
IUUC-Laf-053850	Loxodonta africana	92.81	0.00e+00	1727.00
IUUC-Mcc-055821	Macaca mulatta	94.36	0.00e+00	1749.00
IUUC-Meu-056712	Macropus eugenii	80.18	0.00e+00	762.00
IUUC-Mor-057097	Magnaporthe oryzae	46.88	6.00e-157	547.00
IUUC-Mpo-057442	Magnaporthe poae	51.96	1.00e-145	510.00
IUUC-Mla-058996	Melampsora laricipopulina	46.68	2.00e-155	542.00
IUUC-Mvi-060395	Microbotryum violaceum	53.91	6.00e-151	527.00
IUUC-Mmr-060798	Microcebus murinus	90.32	0.00e+00	1631.00
IUUC-Mdo-062173	Monodelphis domestica	93.16	0.00e+00	1792.00
IUUC-Mmu-064136	Mus musculus	93.03	0.00e+00	1743.00
IUUC-Mpu-066765	Mustela putorius furo	94.26	0.00e+00	1730.00
IUUC-Mlu-067565	Myotis lucifugus	92.49	0.00e+00	1544.00
IUUC-Nfi-068427	Neosartorya fischeri	48.85	5.00e-164	571.00
IUUC-Ncr-068918	Neurospora crassa	47.06	1.00e-156	546.00
IUUC-Nle-069070	Nomascus leucogenys	90.88	0.00e+00	1692.00
IUUC-Opr-071044	Ochotona princeps	94.11	0.00e+00	1178.00
IUUC-Ont-072044	Oreochromis niloticus	77.67	0.00e+00	1467.00
IUUC-Oan-073032	Ornithorhynchus anatinus	91.45	0.00e+00	1427.00
IUUC-Ocu-074160	Oryctolagus cuniculus	91.47	0.00e+00	1671.00
IUUC-Oba-075252	Oryza barthii	44.84	4.00e-91	331.00
IUUC-Oin-079663	Oryza indica	44.84	3.00e-91	331.00
IUUC-Olo-080326	Oryza longistaminata	44.58	4.00e-90	327.00
IUUC-Oni-082342	Oryza nivara	44.84	4.00e-91	331.00
IUUC-Opu-083428	Oryza punctata	45.06	1.00e-91	333.00
IUUC-Oru-084559	Oryza rufipogon	44.84	5.00e-91	330.00
IUUC-Ola-087467	Oryzias latipes	79.61	0.00e+00	1461.00
IUUC-Oga-088460	Otolemur garnettii	90.42	0.00e+00	1531.00
IUUC-Oar-090198	Ovis aries	94.15	0.00e+00	1723.00
IUUC-Ptr-090939	Pan troglodytes	94.26	0.00e+00	1780.00
IUUC-Pan-092284	Papio anubis	94.15	0.00e+00	1778.00
IUUC-Pma-094364	Petromyzon marinus	82.07	0.00e+00	860.00
IUUC-Pno-095118	Phaeosphaeria nodorum	48.84	3.00e-162	565.00
IUUC-Pfo-096768	Poecilia formosa	90.61	0.00e+00	960.00
IUUC-Pab-098088	Pongo abelii	94.29	0.00e+00	1758.00
IUUC-Pca-100714	Procavia capensis	74.81	0.00e+00	1282.00
IUUC-Pva-102354	Pteropus vampyrus	92.18	0.00e+00	1643.00
IUUC-Ptt-103806	Puccinia triticina	53.27	2.00e-123	436.00
IUUC-Pte-104016	Pyrenophora teres	48.50	2.00e-162	565.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	48.50	2.00e-162	565.00
IUUC-Rno-105318	Rattus norvegicus	92.51	0.00e+00	1701.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.08	4.00e-164	571.00
IUUC-Sha-107482	Sarcophilus harrisii	94.67	0.00e+00	1595.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	47.57	2.00e-157	549.00
IUUC-Stu-112582	Solanum tuberosum	36.09	5.00e-55	209.00
IUUC-Sbi-113794	Sorghum bicolor	45.00	3.00e-93	338.00
IUUC-Sre-114929	Sporisorium reilianum	47.32	1.00e-155	543.00
IUUC-Ssc-115950	Sus scrofa	67.98	0.00e+00	1152.00
IUUC-Tgu-117130	Taeniopygia guttata	94.69	0.00e+00	1753.00
IUUC-Tru-118610	Takifugu rubripes	79.88	0.00e+00	1482.00
IUUC-Tsy-119492	Tarsius syrichta	88.55	0.00e+00	1590.00
IUUC-Tni-120113	Tetraodon nigroviridis	75.03	0.00e+00	1354.00
IUUC-Tre-122203	Trichoderma reesei	45.43	2.00e-153	535.00
IUUC-Tvi-122595	Trichoderma virens	47.18	3.00e-155	542.00
IUUC-Tbe-127441	Tupaia belangeri	85.22	0.00e+00	751.00
IUUC-Ttr-128235	Tursiops truncatus	85.46	0.00e+00	1479.00
IUUC-Vda-129753	Verticillium dahliae	47.49	1.00e-157	550.00
IUUC-Xtr-132859	Xenopus tropicalis	89.84	0.00e+00	1664.00
IUUC-Xma-133797	Xiphophorus maculatus	80.71	0.00e+00	1468.00
IUUC-Yli-134668	Yarrowia lipolytica	47.32	5.00e-162	564.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence