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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063380
Ensembl Protein ID ENSMUSP00000033160.8
UniProt Accession Q6P5E6; Q3U374; Q6PFX3; Q6ZPY8; Q8BM76; Q9DC15; GGA2_MOUSE
Genbank Protein ID BAB23426.1; BAC28769.1; BAC98090.1; BAE25501.1; BAE32915.1; AAH57377.1; AAH62933.1
Protein Name ADP-ribosylation factor-binding protein GGA2; Gamma-adaptin-related protein 2; Golgi-localized, gamma ear-containing, ARF-binding protein 2
Genbank Nucleotide ID AK004632; AK034612; AK129280; AK143691; AK154904; BC057377; BC062933
Gene Name Gga2; Kiaa1080
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000030872.14 ENSMUST00000033160.14 ENSMUSP00000033160.8
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/GAT 2.00e-47 161.5 190 316
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/GAT
   S: 1    deeksklLerLlkskkPeDLreAnkLikelvkededkaekikkliseleevksnvkllnemlselspegeepednellqelyetckaar 89
           deeksklL+rLlks++PeDL++An+Lik+lvke+++k+ek+++++s++eev+s+v++l emls++++ g++  d+ +lq +ye+c+++r
   Q: 190  DEEKSKLLTRLLKSNHPEDLQAANRLIKNLVKEEQEKSEKVSRRVSAVEEVRSHVRVLREMLSMYRRPGHALPDQQALQVVYERCEKLR 278
           79*************************************************************************************** PP
   S: 90   pkllklieeeedndellaellkanDelnqvlnkykqlk 127
           p+l++l+++++d+d++lae+l+anD l+q +  ykq++
   Q: 279  PTLFRLASDTTDDDDALAEILQANDLLTQGVRLYKQVV 316
           ***********************************986 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif (By similarity).
 Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif (By similarity).
Protein Sequence
(Fasta)
MAATAVAAGT GSPAGTESAE GGPGAAAALE LWLNKATDPS MAEQDWSAIQ KFCEQVNTDP 60
SGPTHAPWLL AHKIQSPQEK EALYALTVLE ICMNHCGEKF HSEVAKFRFL NELIKVLSPK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063380|UBD,GAT|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGTCCAATA GGGCCCGCCC CGTCACGTGC CTCTCAGTGT CTGCCGCGTC GGCAGCTGGA 60
GCGAAGGCTA GGCGGCGGCG GTGGCTGCAG CTTTTGGGCA GGAGTGACTG CGGCCGCAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063380|UBD,GAT|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR008152--Clathrin_a/b/g-adaptin_app_Ig
IPR008153--Clathrin_g-adaptin_app
IPR013041--Coatomer/clathrin_app_Ig-like
IPR008942--ENTH_VHS
IPR004152--GAT_dom
IPR002014--VHS_dom
PROSITE

PS50180--GAE
PS50909--GAT
PS50179--VHS
Pfam

PF02883--Alpha_adaptinC2
PF03127--GAT
PF00790--VHS
SMART

SM00809--Alpha_adaptinC2
SM00288--VHS
Gene Ontology

GO:0030131--C:clathrin adaptor complex
GO:0030136--C:clathrin-coated vesicle
GO:0010008--C:endosome membrane
GO:0005794--C:Golgi apparatus
GO:0005802--C:trans-Golgi network
GO:0030306--F:ADP-ribosylation factor binding
GO:0006886--P:intracellular protein transport
GO:0016192--P:vesicle-mediated transport
KEGG mmu:74105
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001341 Ailuropoda melanoleuca 84.56 0.00e+00 932.00
IUUC-Afl-008682 Aspergillus flavus 24.76 6.00e-20 92.80
IUUC-Bta-013492 Bos taurus 84.02 0.00e+00 924.00
IUUC-Cja-018800 Callithrix jacchus 83.56 0.00e+00 860.00
IUUC-Cfa-021014 Canis familiaris 84.73 0.00e+00 933.00
IUUC-Cpo-021561 Cavia porcellus 85.23 0.00e+00 914.00
IUUC-Csa-024178 Chlorocebus sabaeus 85.88 0.00e+00 956.00
IUUC-Cho-024564 Choloepus hoffmanni 84.75 1.00e-108 387.00
IUUC-Dno-029286 Dasypus novemcinctus 82.99 0.00e+00 894.00
IUUC-Dor-030125 Dipodomys ordii 77.53 2.00e-169 589.00
IUUC-Ete-032922 Echinops telfairi 79.27 0.00e+00 793.00
IUUC-Eca-034426 Equus caballus 84.91 0.00e+00 985.00
IUUC-Eeu-034886 Erinaceus europaeus 66.88 7.00e-99 354.00
IUUC-Fca-035516 Felis catus 84.98 0.00e+00 947.00
IUUC-Gga-040548 Gallus gallus 68.17 1.00e-112 400.00
IUUC-Ggo-044638 Gorilla gorilla 78.15 0.00e+00 853.00
IUUC-Hsa-045912 Homo sapiens 84.88 0.00e+00 949.00
IUUC-Itr-048824 Ictidomys tridecemlineatus 88.21 0.00e+00 956.00
IUUC-Lma-053070 Leptosphaeria maculans 24.28 3.00e-19 90.10
IUUC-Laf-054401 Loxodonta africana 85.27 0.00e+00 889.00
IUUC-Mcc-055612 Macaca mulatta 85.30 0.00e+00 947.00
IUUC-Meu-056854 Macropus eugenii 67.18 6.00e-88 318.00
IUUC-Mga-060197 Meleagris gallopavo 67.96 1.00e-103 370.00
IUUC-Mmr-061458 Microcebus murinus 81.69 0.00e+00 855.00
IUUC-Mdo-062796 Monodelphis domestica 63.08 0.00e+00 691.00
IUUC-Mpu-066175 Mustela putorius furo 82.70 0.00e+00 863.00
IUUC-Mlu-068058 Myotis lucifugus 87.34 5.00e-132 464.00
IUUC-Nle-069012 Nomascus leucogenys 83.84 0.00e+00 926.00
IUUC-Opr-070412 Ochotona princeps 74.40 0.00e+00 748.00
IUUC-Oan-073129 Ornithorhynchus anatinus 77.60 1.00e-101 363.00
IUUC-Ocu-073919 Oryctolagus cuniculus 74.81 2.00e-147 516.00
IUUC-Oga-087960 Otolemur garnettii 86.23 0.00e+00 905.00
IUUC-Oar-089238 Ovis aries 84.36 0.00e+00 927.00
IUUC-Ptr-090778 Pan troglodytes 78.90 0.00e+00 862.00
IUUC-Pan-092917 Papio anubis 86.05 0.00e+00 955.00
IUUC-Psi-093912 Pelodiscus sinensis 57.06 2.00e-90 326.00
IUUC-Pab-098685 Pongo abelii 78.26 1.00e-178 619.00
IUUC-Pca-100932 Procavia capensis 88.82 2.00e-132 466.00
IUUC-Pva-102575 Pteropus vampyrus 77.80 0.00e+00 828.00
IUUC-Pte-104353 Pyrenophora teres 25.24 4.00e-19 90.10
IUUC-Pyt-104704 Pyrenophora triticirepentis 24.92 8.00e-19 89.00
IUUC-Rno-105093 Rattus norvegicus 97.03 0.00e+00 1025.00
IUUC-Sha-106784 Sarcophilus harrisii 65.16 0.00e+00 711.00
IUUC-Ssc-115750 Sus scrofa 74.40 2.00e-152 533.00
IUUC-Tgu-116453 Taeniopygia guttata 65.74 2.00e-104 372.00
IUUC-Tsy-119576 Tarsius syrichta 75.93 7.00e-92 331.00
IUUC-Tvi-122537 Trichoderma virens 26.52 3.00e-15 77.00
IUUC-Tme-126920 Tuber melanosporum 25.00 1.00e-19 91.70
IUUC-Tbe-127374 Tupaia belangeri 84.60 4.00e-170 591.00
IUUC-Ttr-128868 Tursiops truncatus 80.27 0.00e+00 869.00
Created Date 25-Jun-2017

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