iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.70e-23	82.5	212	285

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 1    evpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceenss 74
           evp+++++ Is+e+ +dPv++psGity+r+ Ie++l++ g+ +Pvtr +lt+++l+Pn +++++++++++en++
   Q: 212  EVPDFLCGKISFEILTDPVITPSGITYERKDIEEHLQRVGHFDPVTRVKLTQDQLIPNFSMKEVVDSFIAENEW 285
           68999*****************************************************************9987 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MTTKHIYSTT NLSDLQLKEQ GNCLFAARKY DDAINCYSKA IIKNPTNATY FTNRALCNLK 60
LKRWELCCQD SRRALDIDGN LLKGHFFLGQ GLMEIDNFDE AIKHLQRAYD LSKEQKQNFG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTAAGCTTGT GAGTCTTGGC AACTCTAGAA ACACATCGAT TAACGTAGCT GAAAATTGTT 60
TTATGTTTAA TTAAATACAG GCGAATAGCT CAAGATCTTT TTGGTGTTAT GAGCGTTCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat

Interpro

IPR007330--MIT
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50005--TPR
PS50293--TPR_REGION
PS51698--U_BOX

Pfam

PF04564--U-box

SMART

SM00028--TPR
SM00504--Ubox

Gene Ontology

GO:0005737--C:cytoplasm
GO:0030544--F:Hsp70 protein binding
GO:0051879--F:Hsp90 protein binding
GO:0046983--F:protein dimerization activity
GO:0046332--F:SMAD binding
GO:0030911--F:TPR domain binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0031943--P:regulation of glucocorticoid metabolic process
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

KEGG

dme:Dmel_CG5203

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000537	Aegilops tauschii	36.55	3.00e-40	157.00
IUUC-Aml-001350	Ailuropoda melanoleuca	57.83	2.00e-84	304.00
IUUC-Atr-003168	Amborella trichopoda	34.76	4.00e-31	127.00
IUUC-Apl-003736	Anas platyrhynchos	57.20	3.00e-83	300.00
IUUC-Aca-004751	Anolis carolinensis	56.00	1.00e-87	315.00
IUUC-Aly-006292	Arabidopsis lyrata	33.70	4.00e-45	174.00
IUUC-Ath-007012	Arabidopsis thaliana	35.90	2.00e-45	174.00
IUUC-Acl-008025	Aspergillus clavatus	30.99	2.00e-40	158.00
IUUC-Afl-008721	Aspergillus flavus	32.65	2.00e-38	151.00
IUUC-Afu-008853	Aspergillus fumigatus	31.10	3.00e-39	154.00
IUUC-Ani-009349	Aspergillus nidulans	29.49	3.00e-36	144.00
IUUC-Ang-009674	Aspergillus niger	31.58	3.00e-38	150.00
IUUC-Aor-010014	Aspergillus oryzae	31.32	5.00e-32	130.00
IUUC-Ate-010467	Aspergillus terreus	31.25	5.00e-34	137.00
IUUC-Ame-011215	Astyanax mexicanus	44.17	9.00e-62	229.00
IUUC-Bgr-011971	Blumeria graminis	28.01	2.00e-22	98.20
IUUC-Bta-013025	Bos taurus	57.82	8.00e-94	335.00
IUUC-Bci-013945	Botrytis cinerea	38.27	7.00e-15	73.60
IUUC-Bdi-014801	Brachypodium distachyon	36.06	4.00e-45	174.00
IUUC-Bol-015676	Brassica oleracea	32.99	4.00e-45	174.00
IUUC-Bra-017897	Brassica rapa	32.88	3.00e-33	134.00
IUUC-Cel-018323	Caenorhabditis elegans	37.97	4.00e-50	190.00
IUUC-Cja-019657	Callithrix jacchus	57.71	3.00e-95	340.00
IUUC-Cfa-020470	Canis familiaris	57.14	7.00e-76	275.00
IUUC-Cpo-022033	Cavia porcellus	58.06	1.00e-95	341.00
IUUC-Cre-022896	Chlamydomonas reinhardtii	26.07	2.00e-29	122.00
IUUC-Csa-023038	Chlorocebus sabaeus	57.71	3.00e-92	330.00
IUUC-Cin-025381	Ciona intestinalis	52.45	1.00e-84	305.00
IUUC-Cgl-026524	Colletotrichum gloeosporioides	32.97	3.00e-39	154.00
IUUC-Dre-027610	Danio rerio	56.68	1.00e-91	328.00
IUUC-Dno-030087	Dasypus novemcinctus	56.99	2.00e-94	337.00
IUUC-Dor-031029	Dipodomys ordii	54.51	3.00e-85	307.00
IUUC-Dse-031275	Dothistroma septosporum	31.99	4.00e-29	120.00
IUUC-Ete-033087	Echinops telfairi	54.51	1.00e-75	275.00
IUUC-Eca-033512	Equus caballus	58.23	5.00e-85	306.00
IUUC-Eeu-034763	Erinaceus europaeus	50.27	6.00e-49	185.00
IUUC-Fca-036460	Felis catus	57.72	8.00e-93	332.00
IUUC-Fal-037441	Ficedula albicollis	57.45	3.00e-92	330.00
IUUC-Fox-038028	Fusarium oxysporum	32.88	8.00e-40	156.00
IUUC-Fso-038323	Fusarium solani	36.20	4.00e-35	140.00
IUUC-Gmo-038511	Gadus morhua	56.20	4.00e-87	313.00
IUUC-Ggr-039964	Gaeumannomyces graminis	30.96	5.00e-28	117.00
IUUC-Gga-040854	Gallus gallus	57.82	4.00e-92	330.00
IUUC-Gac-042175	Gasterosteus aculeatus	54.38	7.00e-83	299.00
IUUC-Gma-044046	Glycine max	35.77	7.00e-45	172.00
IUUC-Ggo-044512	Gorilla gorilla	57.71	3.00e-92	330.00
IUUC-Hsa-046872	Homo sapiens	57.71	3.00e-92	330.00
IUUC-Hvu-047661	Hordeum vulgare	35.79	6.00e-42	163.00
IUUC-Itr-048871	Ictidomys tridecemlineatus	57.35	1.00e-94	338.00
IUUC-Lch-049988	Latimeria chalumnae	54.51	4.00e-88	317.00
IUUC-Lpe-050693	Leersia perrieri	34.80	2.00e-42	165.00
IUUC-Loc-052195	Lepisosteus oculatus	55.38	5.00e-80	289.00
IUUC-Lma-053207	Leptosphaeria maculans	31.82	5.00e-30	125.00
IUUC-Laf-054584	Loxodonta africana	57.65	5.00e-95	339.00
IUUC-Mcc-054689	Macaca mulatta	57.71	3.00e-92	330.00
IUUC-Meu-055998	Macropus eugenii	56.00	6.00e-46	176.00
IUUC-Mor-057116	Magnaporthe oryzae	34.52	6.00e-40	156.00
IUUC-Mtr-057684	Medicago truncatula	36.30	5.00e-40	156.00
IUUC-Mga-059332	Meleagris gallopavo	58.00	9.00e-84	301.00
IUUC-Mmr-061377	Microcebus murinus	57.35	2.00e-91	327.00
IUUC-Mdo-061963	Monodelphis domestica	56.79	4.00e-90	323.00
IUUC-Mmu-063146	Mus musculus	57.71	5.00e-92	329.00
IUUC-Mac-064932	Musa acuminata	36.14	4.00e-28	116.00
IUUC-Mpu-066418	Mustela putorius furo	57.71	2.00e-94	338.00
IUUC-Mlu-067066	Myotis lucifugus	57.71	1.00e-94	338.00
IUUC-Nfi-068601	Neosartorya fischeri	31.10	5.00e-39	153.00
IUUC-Ncr-068761	Neurospora crassa	30.31	8.00e-29	119.00
IUUC-Nle-069374	Nomascus leucogenys	57.71	3.00e-92	330.00
IUUC-Opr-070765	Ochotona princeps	56.83	7.00e-60	221.00
IUUC-Ont-072650	Oreochromis niloticus	56.03	3.00e-92	330.00
IUUC-Oan-072830	Ornithorhynchus anatinus	30.17	7.00e-11	63.50
IUUC-Ocu-073774	Oryctolagus cuniculus	28.45	5.00e-08	53.90
IUUC-Oba-075967	Oryza barthii	34.93	2.00e-42	165.00
IUUC-Obr-076440	Oryza brachyantha	34.04	3.00e-34	140.00
IUUC-Ogl-076959	Oryza glaberrima	36.65	2.00e-47	181.00
IUUC-Ogu-078247	Oryza glumaepatula	36.78	9.00e-43	166.00
IUUC-Oin-079616	Oryza indica	36.65	2.00e-47	181.00
IUUC-Olo-080492	Oryza longistaminata	32.57	6.00e-30	125.00
IUUC-Ome-081935	Oryza meridionalis	27.24	4.00e-22	100.00
IUUC-Oni-082535	Oryza nivara	36.78	9.00e-43	166.00
IUUC-Opu-083794	Oryza punctata	34.93	7.00e-42	163.00
IUUC-Oru-085166	Oryza rufipogon	36.78	9.00e-43	166.00
IUUC-Osa-085936	Oryza sativa	31.30	5.00e-16	76.60
IUUC-Ola-087081	Oryzias latipes	57.66	5.00e-92	330.00
IUUC-Olu-087790	Ostreococcus lucimarinus	29.52	1.00e-30	125.00
IUUC-Oga-088331	Otolemur garnettii	57.35	7.00e-92	329.00
IUUC-Oar-089987	Ovis aries	55.69	4.00e-81	293.00
IUUC-Ptr-090855	Pan troglodytes	57.71	3.00e-92	330.00
IUUC-Pan-092801	Papio anubis	56.63	5.00e-94	336.00
IUUC-Psi-093393	Pelodiscus sinensis	56.80	9.00e-82	295.00
IUUC-Pma-094680	Petromyzon marinus	57.76	1.00e-88	318.00
IUUC-Pno-094913	Phaeosphaeria nodorum	32.98	7.00e-34	136.00
IUUC-Ppa-095508	Physcomitrella patens	33.64	4.00e-47	181.00
IUUC-Pfo-096850	Poecilia formosa	57.66	2.00e-88	318.00
IUUC-Pab-097963	Pongo abelii	57.71	3.00e-92	330.00
IUUC-Pop-098805	Populus trichocarpa	33.51	2.00e-24	104.00
IUUC-Pca-100788	Procavia capensis	58.06	2.00e-94	337.00
IUUC-Ppe-101221	Prunus persica	35.02	1.00e-44	172.00
IUUC-Pva-103076	Pteropus vampyrus	57.35	3.00e-93	333.00
IUUC-Pte-104237	Pyrenophora teres	34.17	1.00e-33	136.00
IUUC-Pyt-104468	Pyrenophora triticirepentis	34.17	2.00e-33	135.00
IUUC-Rno-105204	Rattus norvegicus	58.06	2.00e-92	331.00
IUUC-Sha-106579	Sarcophilus harrisii	54.51	2.00e-79	288.00
IUUC-Smo-109215	Selaginella moellendorffii	33.56	4.00e-41	160.00
IUUC-Sit-110665	Setaria italica	38.52	5.00e-48	183.00
IUUC-Sly-111473	Solanum lycopersicum	37.00	2.00e-45	175.00
IUUC-Stu-112353	Solanum tuberosum	36.26	1.00e-44	172.00
IUUC-Sar-113589	Sorex araneus	27.59	2.00e-08	55.10
IUUC-Sbi-113887	Sorghum bicolor	37.92	4.00e-48	184.00
IUUC-Ssc-115416	Sus scrofa	57.35	8.00e-94	335.00
IUUC-Tgu-117272	Taeniopygia guttata	66.35	6.00e-40	154.00
IUUC-Tru-117777	Takifugu rubripes	58.03	5.00e-88	316.00
IUUC-Tni-120572	Tetraodon nigroviridis	56.93	1.00e-86	312.00
IUUC-Tca-121149	Theobroma cacao	37.36	5.00e-48	183.00
IUUC-Tre-122230	Trichoderma reesei	32.97	8.00e-33	132.00
IUUC-Tvi-122678	Trichoderma virens	35.38	7.00e-43	166.00
IUUC-Tae-122986	Triticum aestivum	35.79	1.00e-45	176.00
IUUC-Tur-126009	Triticum urartu	35.34	2.00e-39	154.00
IUUC-Tme-126948	Tuber melanosporum	33.82	1.00e-38	152.00
IUUC-Tbe-127996	Tupaia belangeri	26.72	2.00e-06	48.90
IUUC-Ttr-129031	Tursiops truncatus	58.06	7.00e-95	339.00
IUUC-Vda-130023	Verticillium dahliae	32.73	1.00e-39	155.00
IUUC-Vvi-131091	Vitis vinifera	43.14	5.00e-23	99.40
IUUC-Xtr-132871	Xenopus tropicalis	56.69	2.00e-89	321.00
IUUC-Xma-134220	Xiphophorus maculatus	57.30	4.00e-88	316.00
IUUC-Yli-134462	Yarrowia lipolytica	31.75	8.00e-32	129.00
IUUC-Zma-135773	Zea mays	35.77	1.00e-46	179.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence