iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Cel-018328

UUCD1 version

UUC-CaE-00284

Ensembl Protein ID

F59E10.2

UniProt Accession

P52012; Q09548; PPIL2_CAEEL

Genbank Protein ID

AAC06337.1; AAL27008.1; CAA85417.1; CAA85417.1

Protein Name

Peptidyl-prolyl cis-trans isomerase 4; Cyclophilin mog-6; Cyclophilin-4; Masculinization of germline protein 6; RING-type E3 ubiquitin transferase isomerase 4; Rotamase 4

Genbank Nucleotide ID

U36187; AF421146; Z36949; Z46935

Gene Name

cyn-4; cyp-4; mog-6; F59E10.2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00000880	F59E10.2	F59E10.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA
Protein-protein Interaction
IID	PINA
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.20e-11	44.8	44	93

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 7    lCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvP 57
           +C++sl +++dPv++ sG  +d ++I  +l++ gk +P t++pl  +dl+ 
   Q: 44   HCSLSLLPFEDPVCARSGEIFDLTAIVPYLKKHGK-NPCTGKPLVAKDLIH 93
           7*********************************9.*********999985 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins. Influences the hermaphrodite switch from spermatogenesis to oogenesis. Required for body wall muscle cell development.

Protein Sequence
(Fasta)

MGKKQHQKDK LYLTTSEWKS IGGHKDDTGT RLQRAQFKRL PINHCSLSLL PFEDPVCARS 60
GEIFDLTAIV PYLKKHGKNP CTGKPLVAKD LIHLKFDKGE DGKFRCPVTF RTFTDHSHIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAAAATGGG AAAAAAGCAA CATCAGAAAG ATAAACTCTA TCTGACCACT TCTGAATGGA 60
AATCGATTGG AGGACATAAA GATGGTTTTT ATTTAAACAC GAGTTATAAA TAAAAACAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0413--Isomerase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0697--Rotamase
KW-0726--Sexual differentiation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR029000--Cyclophilin-like_dom
IPR024936--Cyclophilin-type_PPIase
IPR020892--Cyclophilin-type_PPIase_CS
IPR002130--Cyclophilin-type_PPIase_dom
IPR027799--Rtf2_RING-finger
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS00170--CSA_PPIASE_1
PS50072--CSA_PPIASE_2
PS51698--U_BOX

Pfam

PF00160--Pro_isomerase
PF04641--Rtf2

PRINTS

PR00153--CSAPPISMRASE

SMART

SM00504--Ubox

Gene Ontology

GO:0005634--C:nucleus
GO:0003755--F:peptidyl-prolyl cis-trans isomerase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030154--P:cell differentiation
GO:0040022--P:feminization of hermaphroditic germ-line
GO:0006457--P:protein folding
GO:0007548--P:sex differentiation

KEGG

cel:CELE_F59E10.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000982	Aegilops tauschii	50.32	1.00e-41	163.00
IUUC-Aml-002351	Ailuropoda melanoleuca	45.60	1.00e-140	491.00
IUUC-Atr-002724	Amborella trichopoda	39.50	4.00e-50	191.00
IUUC-Apl-003515	Anas platyrhynchos	49.09	2.00e-119	421.00
IUUC-Aca-004802	Anolis carolinensis	50.00	7.00e-139	486.00
IUUC-Aly-005928	Arabidopsis lyrata	44.55	2.00e-51	195.00
IUUC-Ath-007574	Arabidopsis thaliana	46.31	4.00e-51	194.00
IUUC-Acl-008183	Aspergillus clavatus	40.24	3.00e-87	314.00
IUUC-Afl-008382	Aspergillus flavus	42.49	1.00e-96	345.00
IUUC-Afu-008952	Aspergillus fumigatus	40.97	1.00e-89	322.00
IUUC-Ani-009146	Aspergillus nidulans	39.78	1.00e-92	332.00
IUUC-Ang-009743	Aspergillus niger	39.23	7.00e-96	343.00
IUUC-Aor-010027	Aspergillus oryzae	43.12	5.00e-95	340.00
IUUC-Ate-010569	Aspergillus terreus	40.93	2.00e-93	335.00
IUUC-Ame-010783	Astyanax mexicanus	50.38	5.00e-141	493.00
IUUC-Bgr-012172	Blumeria graminis	35.73	3.00e-66	244.00
IUUC-Bta-012459	Bos taurus	45.80	1.00e-130	458.00
IUUC-Bci-013693	Botrytis cinerea	40.52	5.00e-94	337.00
IUUC-Bdi-014623	Brachypodium distachyon	45.91	5.00e-53	201.00
IUUC-Bol-015781	Brassica oleracea	47.29	5.00e-52	197.00
IUUC-Bra-016624	Brassica rapa	47.29	3.00e-52	198.00
IUUC-Cja-019427	Callithrix jacchus	47.77	2.00e-131	461.00
IUUC-Cfa-020829	Canis familiaris	48.80	7.00e-139	486.00
IUUC-Cpo-022189	Cavia porcellus	48.87	2.00e-134	471.00
IUUC-Cre-022723	Chlamydomonas reinhardtii	47.71	2.00e-54	206.00
IUUC-Csa-024212	Chlorocebus sabaeus	47.71	1.00e-129	455.00
IUUC-Cin-025720	Ciona intestinalis	45.45	2.00e-136	477.00
IUUC-Csv-026137	Ciona savignyi	47.35	2.00e-128	451.00
IUUC-Cgl-026532	Colletotrichum gloeosporioides	38.35	4.00e-91	327.00
IUUC-Cne-026830	Cryptococcus neoformans	37.37	1.00e-91	329.00
IUUC-Dre-028561	Danio rerio	48.68	4.00e-136	476.00
IUUC-Dno-029029	Dasypus novemcinctus	43.62	5.00e-119	420.00
IUUC-Dor-030683	Dipodomys ordii	41.36	1.00e-43	169.00
IUUC-Dse-031506	Dothistroma septosporum	43.12	4.00e-49	187.00
IUUC-Dme-032058	Drosophila melanogaster	47.62	5.00e-133	466.00
IUUC-Ete-033157	Echinops telfairi	40.64	3.00e-96	344.00
IUUC-Eca-034176	Equus caballus	50.31	2.00e-41	162.00
IUUC-Eeu-034470	Erinaceus europaeus	44.01	2.00e-81	295.00
IUUC-Fca-036571	Felis catus	47.74	1.00e-132	465.00
IUUC-Fal-037613	Ficedula albicollis	48.26	9.00e-125	439.00
IUUC-Fox-037795	Fusarium oxysporum	37.31	1.00e-96	345.00
IUUC-Fso-038213	Fusarium solani	36.45	9.00e-89	319.00
IUUC-Gmo-039609	Gadus morhua	49.34	2.00e-126	444.00
IUUC-Ggr-039825	Gaeumannomyces graminis	37.47	2.00e-90	325.00
IUUC-Gga-041191	Gallus gallus	48.77	2.00e-132	464.00
IUUC-Gac-041524	Gasterosteus aculeatus	51.61	1.00e-132	465.00
IUUC-Gma-042936	Glycine max	45.25	2.00e-50	192.00
IUUC-Ggo-045352	Gorilla gorilla	48.12	2.00e-134	471.00
IUUC-Hsa-045709	Homo sapiens	48.12	3.00e-134	470.00
IUUC-Hvu-047058	Hordeum vulgare	49.02	2.00e-53	202.00
IUUC-Itr-048483	Ictidomys tridecemlineatus	52.44	6.00e-129	452.00
IUUC-Lch-049681	Latimeria chalumnae	47.56	8.00e-120	422.00
IUUC-Lpe-050799	Leersia perrieri	46.15	6.00e-53	200.00
IUUC-Loc-052566	Lepisosteus oculatus	50.00	5.00e-61	227.00
IUUC-Lma-053028	Leptosphaeria maculans	41.73	8.00e-95	339.00
IUUC-Laf-054547	Loxodonta africana	48.20	1.00e-136	478.00
IUUC-Mcc-054753	Macaca mulatta	49.21	1.00e-132	465.00
IUUC-Meu-056855	Macropus eugenii	36.52	1.00e-53	201.00
IUUC-Mor-056941	Magnaporthe oryzae	35.45	8.00e-82	296.00
IUUC-Mpo-057306	Magnaporthe poae	37.00	2.00e-97	348.00
IUUC-Mtr-058349	Medicago truncatula	44.80	2.00e-50	192.00
IUUC-Mla-058842	Melampsora laricipopulina	38.20	4.00e-93	333.00
IUUC-Mga-060099	Meleagris gallopavo	45.93	2.00e-114	404.00
IUUC-Mvi-060413	Microbotryum violaceum	39.04	2.00e-92	331.00
IUUC-Mmr-061530	Microcebus murinus	48.41	2.00e-135	474.00
IUUC-Mdo-062668	Monodelphis domestica	52.28	1.00e-131	461.00
IUUC-Mmu-063871	Mus musculus	49.15	9.00e-139	485.00
IUUC-Mac-064559	Musa acuminata	44.34	2.00e-50	192.00
IUUC-Mpu-065919	Mustela putorius furo	48.41	1.00e-137	481.00
IUUC-Mlu-067846	Myotis lucifugus	41.52	6.00e-120	423.00
IUUC-Nfi-068507	Neosartorya fischeri	40.04	1.00e-84	306.00
IUUC-Ncr-068805	Neurospora crassa	39.43	3.00e-76	278.00
IUUC-Nle-070125	Nomascus leucogenys	46.31	3.00e-125	440.00
IUUC-Opr-070486	Ochotona princeps	48.97	4.00e-105	373.00
IUUC-Ont-071597	Oreochromis niloticus	51.22	7.00e-141	492.00
IUUC-Oan-073439	Ornithorhynchus anatinus	60.32	6.00e-20	87.40
IUUC-Ocu-074411	Oryctolagus cuniculus	49.25	1.00e-134	472.00
IUUC-Oba-075040	Oryza barthii	46.15	4.00e-53	201.00
IUUC-Obr-076727	Oryza brachyantha	46.15	2.00e-52	199.00
IUUC-Ogl-077605	Oryza glaberrima	46.15	4.00e-53	201.00
IUUC-Ogu-078177	Oryza glumaepatula	46.15	4.00e-53	201.00
IUUC-Oin-079549	Oryza indica	45.70	9.00e-53	200.00
IUUC-Olo-081090	Oryza longistaminata	46.15	4.00e-53	201.00
IUUC-Ome-081979	Oryza meridionalis	46.15	4.00e-53	201.00
IUUC-Oni-082819	Oryza nivara	45.70	1.00e-52	199.00
IUUC-Opu-083212	Oryza punctata	46.15	5.00e-53	201.00
IUUC-Oru-084412	Oryza rufipogon	46.15	4.00e-53	201.00
IUUC-Osa-085431	Oryza sativa	50.37	3.00e-37	145.00
IUUC-Ola-086602	Oryzias latipes	49.31	3.00e-120	424.00
IUUC-Olu-087682	Ostreococcus lucimarinus	42.70	1.00e-86	312.00
IUUC-Oga-088999	Otolemur garnettii	44.85	5.00e-125	439.00
IUUC-Oar-089338	Ovis aries	41.26	3.00e-99	354.00
IUUC-Ptr-091185	Pan troglodytes	48.12	2.00e-134	471.00
IUUC-Pan-092321	Papio anubis	48.79	1.00e-136	478.00
IUUC-Psi-094018	Pelodiscus sinensis	50.00	2.00e-70	257.00
IUUC-Pma-094111	Petromyzon marinus	48.28	3.00e-92	330.00
IUUC-Pno-094782	Phaeosphaeria nodorum	41.80	5.00e-95	340.00
IUUC-Ppa-095335	Physcomitrella patens	46.85	4.00e-55	207.00
IUUC-Pfo-097393	Poecilia formosa	50.94	3.00e-138	483.00
IUUC-Pab-098263	Pongo abelii	45.23	3.00e-120	424.00
IUUC-Pop-099316	Populus trichocarpa	40.74	2.00e-82	298.00
IUUC-Pca-100387	Procavia capensis	48.47	7.00e-41	160.00
IUUC-Ppe-101275	Prunus persica	44.55	8.00e-52	196.00
IUUC-Pva-102150	Pteropus vampyrus	41.03	1.00e-107	382.00
IUUC-Pgr-103378	Puccinia graminis	43.38	1.00e-97	349.00
IUUC-Ptt-103908	Puccinia triticina	39.02	2.00e-88	318.00
IUUC-Pte-104248	Pyrenophora teres	41.65	5.00e-99	353.00
IUUC-Pyt-104645	Pyrenophora triticirepentis	41.96	2.00e-99	355.00
IUUC-Rno-105162	Rattus norvegicus	49.91	1.00e-136	478.00
IUUC-Sha-107123	Sarcophilus harrisii	50.37	4.00e-60	224.00
IUUC-Sja-107828	Schizosaccharomyces japonicus	38.49	6.00e-93	333.00
IUUC-Spo-108368	Schizosaccharomyces pombe	37.85	2.00e-94	338.00
IUUC-Smo-109102	Selaginella moellendorffii	50.23	5.00e-58	217.00
IUUC-Sit-110821	Setaria italica	47.73	2.00e-54	205.00
IUUC-Sly-111803	Solanum lycopersicum	43.89	6.00e-51	194.00
IUUC-Stu-112730	Solanum tuberosum	43.89	7.00e-51	193.00
IUUC-Sar-113618	Sorex araneus	49.01	6.00e-127	446.00
IUUC-Sbi-114487	Sorghum bicolor	48.87	2.00e-54	205.00
IUUC-Sre-115009	Sporisorium reilianum	36.67	3.00e-85	308.00
IUUC-Ssc-115984	Sus scrofa	48.04	5.00e-135	473.00
IUUC-Tgu-117410	Taeniopygia guttata	49.15	1.00e-131	461.00
IUUC-Tru-118537	Takifugu rubripes	50.28	3.00e-137	480.00
IUUC-Tsy-119318	Tarsius syrichta	37.54	2.00e-51	195.00
IUUC-Tni-120514	Tetraodon nigroviridis	50.46	5.00e-105	373.00
IUUC-Tca-121620	Theobroma cacao	44.59	1.00e-49	189.00
IUUC-Tre-121904	Trichoderma reesei	34.41	8.00e-72	263.00
IUUC-Tvi-122585	Trichoderma virens	35.87	5.00e-75	273.00
IUUC-Tae-125342	Triticum aestivum	46.36	5.00e-53	201.00
IUUC-Tur-126759	Triticum urartu	52.03	6.00e-41	160.00
IUUC-Tme-126960	Tuber melanosporum	41.62	1.00e-106	379.00
IUUC-Tbe-127839	Tupaia belangeri	37.72	2.00e-37	148.00
IUUC-Ttr-129173	Tursiops truncatus	40.07	4.00e-97	347.00
IUUC-Uma-129595	Ustilago maydis	38.10	2.00e-74	272.00
IUUC-Vda-130012	Verticillium dahliae	39.44	2.00e-95	341.00
IUUC-Vpa-130129	Vicugna pacos	50.31	1.00e-41	163.00
IUUC-Vvi-131156	Vitis vinifera	47.92	5.00e-50	191.00
IUUC-Xtr-132807	Xenopus tropicalis	46.80	1.00e-132	465.00
IUUC-Xma-133940	Xiphophorus maculatus	47.31	3.00e-38	149.00
IUUC-Yli-134361	Yarrowia lipolytica	30.25	2.00e-36	145.00
IUUC-Zma-135759	Zea mays	40.07	6.00e-48	184.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence