iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132444

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAMC01090695

Gene Name

usp22

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000006051.3	ENSXETT00000013325.3	ENSXETP00000013325.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-92	310.3	175	518

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ +++k++ +   +p+ +l++++ +lf+e+++++++   p +ll+ +++ a+++ gyeqq
   Q: 175  GLINLGNTCFMNCIVQALTHTPLLRDFFLS-DRHKCEMQ---SPNSCLVCEMSTLFQEFYSGHRSPHIPYRLLHLVWTHARHLAGYEQQ 259
           9*****************************.99999975...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  ++ ++ +++++ +++i+++F g l+s+++c+ c+ vs++ +pf+d+sl++pg+
   Q: 260  DAHEFLIAALDVLHRHCKG----------------DDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGS 332
           *****************22................22335677899999**************************************** PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
           ++   +                    +l+dcL+ ft++e+l ++ k++c+ c+++qe++k+l++kklP v ++hLkRf  +++ k r+k
   Q: 333  STPFWPlspgsdsavvngeshvsgttTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRF--EHSAKLRRK 419
           *877779***********************************************************************..5666899** PP
   S: 249  inkkvefpleLdlspfctspeekqke............kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevlee 325
           i+++v+fp eLd++pf++s++e+  +            ++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++vl  
   Q: 420  ITTYVSFPWELDMTPFMASSKESRMNgqyqqpsdslhnDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIKDVLD- 507
           *******************4444444555566666666**************************************************. PP
   S: 326  tgstaYvlfYkrr 338
             s++Y+lfY+++
   Q: 508  --SEGYLLFYHKQ 518
           ..********985 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MSPAGCSHVN SFKVENWKQN LRVIYQCFVW SGTPETRKRK AKSCICHMCG AHLNRLHSCL 60
YCVFFGCFTK KHIHEHAKNK RHNLAIDLLY GGIYCFMCQD YIYDKDMEQV AKEEQRKAWK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAAGGAGCT GGACACTAAC GGCGTTACGG GACGTTTAAG CAGCGATCCG GGACTGCAGG 60
CTGTGTTAAG AAAGGCGGGT TTGGACAGCG GGACTGTTGG GCGGTATGCT TAATGGTTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	37.85	3.00e-64	239.00
IUUC-Aml-001343	Ailuropoda melanoleuca	89.48	0.00e+00	999.00
IUUC-Atr-002653	Amborella trichopoda	36.97	2.00e-101	362.00
IUUC-Apl-003433	Anas platyrhynchos	96.49	0.00e+00	988.00
IUUC-Aca-005347	Anolis carolinensis	92.41	0.00e+00	1045.00
IUUC-Aly-006565	Arabidopsis lyrata	36.13	1.00e-71	263.00
IUUC-Ath-007536	Arabidopsis thaliana	36.56	1.00e-71	263.00
IUUC-Ago-007811	Ashbya gossypii	29.67	3.00e-51	195.00
IUUC-Acl-008124	Aspergillus clavatus	30.80	1.00e-56	213.00
IUUC-Afl-008464	Aspergillus flavus	31.63	8.00e-53	200.00
IUUC-Afu-008912	Aspergillus fumigatus	30.34	2.00e-54	206.00
IUUC-Ani-009168	Aspergillus nidulans	31.24	1.00e-56	213.00
IUUC-Ang-009694	Aspergillus niger	30.16	9.00e-54	204.00
IUUC-Aor-010035	Aspergillus oryzae	34.83	6.00e-38	150.00
IUUC-Ate-010382	Aspergillus terreus	30.70	6.00e-51	194.00
IUUC-Ame-011253	Astyanax mexicanus	85.19	0.00e+00	842.00
IUUC-Bgr-012150	Blumeria graminis	30.69	3.00e-48	186.00
IUUC-Bta-013303	Bos taurus	90.25	0.00e+00	1005.00
IUUC-Bci-013604	Botrytis cinerea	31.85	2.00e-55	209.00
IUUC-Bdi-014171	Brachypodium distachyon	35.56	1.00e-76	280.00
IUUC-Bol-016509	Brassica oleracea	37.87	2.00e-75	277.00
IUUC-Bra-016962	Brassica rapa	35.80	2.00e-72	266.00
IUUC-Cja-019283	Callithrix jacchus	91.80	0.00e+00	850.00
IUUC-Cfa-021239	Canis familiaris	91.15	0.00e+00	940.00
IUUC-Cpo-022354	Cavia porcellus	90.44	0.00e+00	1003.00
IUUC-Csa-023145	Chlorocebus sabaeus	91.20	0.00e+00	1011.00
IUUC-Cho-024938	Choloepus hoffmanni	79.39	3.00e-60	225.00
IUUC-Cin-025109	Ciona intestinalis	56.81	7.00e-122	430.00
IUUC-Csv-026214	Ciona savignyi	54.90	2.00e-174	605.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	29.70	1.00e-53	203.00
IUUC-Cne-027085	Cryptococcus neoformans	33.15	9.00e-65	241.00
IUUC-Dre-027433	Danio rerio	92.34	0.00e+00	927.00
IUUC-Dno-030095	Dasypus novemcinctus	91.32	0.00e+00	940.00
IUUC-Dor-030832	Dipodomys ordii	84.54	3.00e-96	345.00
IUUC-Dse-031415	Dothistroma septosporum	30.00	9.00e-61	227.00
IUUC-Dme-032074	Drosophila melanogaster	50.55	8.00e-139	486.00
IUUC-Ete-033175	Echinops telfairi	71.90	0.00e+00	672.00
IUUC-Eca-033736	Equus caballus	91.12	0.00e+00	933.00
IUUC-Eeu-034814	Erinaceus europaeus	96.19	8.00e-120	424.00
IUUC-Fca-035861	Felis catus	91.53	0.00e+00	938.00
IUUC-Fal-037645	Ficedula albicollis	96.64	0.00e+00	974.00
IUUC-Fox-038046	Fusarium oxysporum	31.47	2.00e-53	203.00
IUUC-Fso-038321	Fusarium solani	31.87	4.00e-53	201.00
IUUC-Gmo-038474	Gadus morhua	93.92	5.00e-170	590.00
IUUC-Ggr-040044	Gaeumannomyces graminis	30.72	6.00e-54	204.00
IUUC-Gga-040624	Gallus gallus	95.43	0.00e+00	1056.00
IUUC-Gac-042197	Gasterosteus aculeatus	87.02	0.00e+00	944.00
IUUC-Gma-042897	Glycine max	32.60	1.00e-82	300.00
IUUC-Ggo-044409	Gorilla gorilla	91.40	0.00e+00	1013.00
IUUC-Hsa-046521	Homo sapiens	91.40	0.00e+00	1012.00
IUUC-Hvu-047739	Hordeum vulgare	38.95	2.00e-69	255.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	90.44	0.00e+00	1005.00
IUUC-Kpa-049135	Komagataella pastoris	33.82	1.00e-66	246.00
IUUC-Lch-050537	Latimeria chalumnae	94.46	0.00e+00	1038.00
IUUC-Lpe-050969	Leersia perrieri	38.37	4.00e-73	268.00
IUUC-Loc-052765	Lepisosteus oculatus	87.01	0.00e+00	940.00
IUUC-Lma-053105	Leptosphaeria maculans	34.15	1.00e-62	233.00
IUUC-Laf-053571	Loxodonta africana	92.15	0.00e+00	942.00
IUUC-Mcc-055166	Macaca mulatta	91.20	0.00e+00	1011.00
IUUC-Mor-057103	Magnaporthe oryzae	29.34	2.00e-54	206.00
IUUC-Mpo-057621	Magnaporthe poae	31.14	4.00e-54	205.00
IUUC-Mtr-057894	Medicago truncatula	36.50	3.00e-85	309.00
IUUC-Mla-059185	Melampsora laricipopulina	29.76	6.00e-42	164.00
IUUC-Mga-059709	Meleagris gallopavo	96.49	0.00e+00	988.00
IUUC-Mvi-060530	Microbotryum violaceum	33.11	2.00e-57	216.00
IUUC-Mmr-060988	Microcebus murinus	91.01	0.00e+00	1011.00
IUUC-Mdo-063065	Monodelphis domestica	95.03	0.00e+00	1043.00
IUUC-Mmu-063829	Mus musculus	90.63	0.00e+00	1006.00
IUUC-Mac-065419	Musa acuminata	39.84	7.00e-72	264.00
IUUC-Mpu-066687	Mustela putorius furo	90.25	0.00e+00	999.00
IUUC-Mlu-067330	Myotis lucifugus	81.30	0.00e+00	893.00
IUUC-Nfi-068423	Neosartorya fischeri	30.34	2.00e-54	206.00
IUUC-Ncr-068809	Neurospora crassa	30.32	2.00e-55	210.00
IUUC-Nle-069261	Nomascus leucogenys	87.38	0.00e+00	958.00
IUUC-Opr-070469	Ochotona princeps	74.66	0.00e+00	664.00
IUUC-Ont-071961	Oreochromis niloticus	89.10	0.00e+00	974.00
IUUC-Oan-073565	Ornithorhynchus anatinus	89.47	0.00e+00	957.00
IUUC-Ocu-074435	Oryctolagus cuniculus	90.78	0.00e+00	982.00
IUUC-Oba-075688	Oryza barthii	35.69	2.00e-75	276.00
IUUC-Obr-076652	Oryza brachyantha	41.42	5.00e-74	271.00
IUUC-Ogl-077910	Oryza glaberrima	36.09	8.00e-80	291.00
IUUC-Ogu-078479	Oryza glumaepatula	36.09	8.00e-80	291.00
IUUC-Oin-079697	Oryza indica	39.66	2.00e-75	276.00
IUUC-Olo-080811	Oryza longistaminata	41.38	7.00e-53	200.00
IUUC-Ome-081706	Oryza meridionalis	36.09	3.00e-79	289.00
IUUC-Oni-083070	Oryza nivara	35.89	9.00e-80	290.00
IUUC-Opu-083605	Oryza punctata	39.89	5.00e-67	247.00
IUUC-Oru-084522	Oryza rufipogon	36.09	8.00e-80	291.00
IUUC-Osa-085351	Oryza sativa	39.61	3.00e-76	279.00
IUUC-Ola-086743	Oryzias latipes	84.65	0.00e+00	744.00
IUUC-Olu-087695	Ostreococcus lucimarinus	31.81	2.00e-50	192.00
IUUC-Oga-089131	Otolemur garnettii	91.03	0.00e+00	1012.00
IUUC-Oar-089319	Ovis aries	91.72	0.00e+00	937.00
IUUC-Ptr-090783	Pan troglodytes	92.15	0.00e+00	943.00
IUUC-Pan-092927	Papio anubis	91.01	0.00e+00	1010.00
IUUC-Psi-093670	Pelodiscus sinensis	95.52	0.00e+00	989.00
IUUC-Pma-094323	Petromyzon marinus	67.81	0.00e+00	710.00
IUUC-Pno-095141	Phaeosphaeria nodorum	30.40	3.00e-54	205.00
IUUC-Ppa-095413	Physcomitrella patens	34.62	5.00e-84	305.00
IUUC-Pfo-096462	Poecilia formosa	89.41	0.00e+00	996.00
IUUC-Pab-097612	Pongo abelii	91.40	0.00e+00	1013.00
IUUC-Pop-099558	Populus trichocarpa	34.80	2.00e-86	313.00
IUUC-Pca-100329	Procavia capensis	80.92	0.00e+00	891.00
IUUC-Ppe-102020	Prunus persica	36.06	5.00e-92	331.00
IUUC-Pva-102721	Pteropus vampyrus	77.29	0.00e+00	835.00
IUUC-Pgr-103657	Puccinia graminis	29.31	3.00e-37	149.00
IUUC-Pte-104340	Pyrenophora teres	31.52	2.00e-56	213.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	34.58	6.00e-64	238.00
IUUC-Rno-105247	Rattus norvegicus	90.63	0.00e+00	1007.00
IUUC-Sce-106247	Saccharomyces cerevisiae	30.48	9.00e-51	194.00
IUUC-Sha-107538	Sarcophilus harrisii	94.93	5.00e-123	432.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	33.87	3.00e-67	248.00
IUUC-Spo-108226	Schizosaccharomyces pombe	31.49	1.00e-60	226.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	31.08	6.00e-53	201.00
IUUC-Smo-109310	Selaginella moellendorffii	35.51	2.00e-88	319.00
IUUC-Sit-109716	Setaria italica	35.61	3.00e-79	289.00
IUUC-Sly-111077	Solanum lycopersicum	37.04	6.00e-81	294.00
IUUC-Stu-112203	Solanum tuberosum	38.48	1.00e-72	266.00
IUUC-Sar-113174	Sorex araneus	78.69	0.00e+00	810.00
IUUC-Sbi-114205	Sorghum bicolor	35.07	2.00e-80	292.00
IUUC-Sre-115195	Sporisorium reilianum	34.35	5.00e-29	122.00
IUUC-Ssc-115315	Sus scrofa	82.25	0.00e+00	911.00
IUUC-Tgu-116938	Taeniopygia guttata	94.63	0.00e+00	959.00
IUUC-Tru-117622	Takifugu rubripes	91.59	0.00e+00	1014.00
IUUC-Tsy-119431	Tarsius syrichta	80.12	0.00e+00	788.00
IUUC-Tni-120119	Tetraodon nigroviridis	91.59	0.00e+00	1009.00
IUUC-Tca-121154	Theobroma cacao	36.70	9.00e-90	324.00
IUUC-Tre-122139	Trichoderma reesei	31.78	2.00e-52	199.00
IUUC-Tvi-122599	Trichoderma virens	31.24	2.00e-53	203.00
IUUC-Tae-125608	Triticum aestivum	34.36	4.00e-87	315.00
IUUC-Tme-127115	Tuber melanosporum	36.31	6.00e-80	291.00
IUUC-Ttr-129006	Tursiops truncatus	81.32	0.00e+00	879.00
IUUC-Uma-129455	Ustilago maydis	30.36	2.00e-32	134.00
IUUC-Vda-129829	Verticillium dahliae	33.55	1.00e-35	142.00
IUUC-Vvi-131477	Vitis vinifera	35.77	1.00e-78	287.00
IUUC-Xma-133514	Xiphophorus maculatus	91.97	0.00e+00	1010.00
IUUC-Yli-134357	Yarrowia lipolytica	27.94	1.00e-48	187.00
IUUC-Zma-134945	Zea mays	35.35	1.00e-77	283.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence