iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-098051

Ensembl Protein ID

ENSPPYP00000016243.2

UniProt Accession

H2PCP9; H2PCP9_PONAB

Genbank Protein ID

ENSPPYP00000016243

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

ABGA01345223

Gene Name

WHSC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000014534.2	ENSPPYT00000016899.2	ENSPPYP00000016243.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.10e-15	57.6	833	873

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC +gg+    l++Ce C  +fHp+Cl+++    +p+ + w+C++Cr
   Q: 833  WCFVCSKGGS----LLCCESCPAAFHPDCLNIE----MPDGS-WFCNDCR 873
           8*********....*******************....9***8.******8 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MEFSIKQSPL SLQSVVKCIK MKQAPEILGS ANGKTPSCEV NRECSVFLSK AQLSSSLQEG 60
VMQKFNGHDA LPFIPADKLK DLTSRVFNGE PGTHDAKLRF ESQEMKGIGT PPNTTPIKNG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCCGCCGC CGCCGCCGCC CCCTCCCCGC CTGGGCTCTA CCGCCGCACG GCCCCGGCCC 60
CCTCCCAGCC TGCCGCTCCG GAGAGCCGCC CGCCGAGGAT GCGACGCACC GCAGGTCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50118--HMG_BOX_2
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF00505--HMG_box
PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00184--RING
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0003289--P:atrial septum primum morphogenesis
GO:0003290--P:atrial septum secundum morphogenesis
GO:0060348--P:bone development
GO:0010452--P:histone H3-K36 methylation
GO:0034770--P:histone H4-K20 methylation
GO:0003149--P:membranous septum morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048298--P:positive regulation of isotype switching to IgA isotypes
GO:2001032--P:regulation of double-strand break repair via nonhomologous end joining
GO:0070201--P:regulation of establishment of protein localization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002181	Ailuropoda melanoleuca	92.04	0.00e+00	2424.00
IUUC-Apl-003677	Anas platyrhynchos	81.10	0.00e+00	2152.00
IUUC-Aca-004278	Anolis carolinensis	75.75	0.00e+00	1415.00
IUUC-Ame-011932	Astyanax mexicanus	70.10	0.00e+00	1029.00
IUUC-Bta-012522	Bos taurus	86.66	0.00e+00	2255.00
IUUC-Cja-018908	Callithrix jacchus	97.91	0.00e+00	2502.00
IUUC-Cfa-020894	Canis familiaris	91.39	0.00e+00	2466.00
IUUC-Cpo-021982	Cavia porcellus	89.55	0.00e+00	2375.00
IUUC-Csa-023807	Chlorocebus sabaeus	98.36	0.00e+00	2538.00
IUUC-Cho-024405	Choloepus hoffmanni	74.01	0.00e+00	732.00
IUUC-Csv-026298	Ciona savignyi	39.29	9.00e-58	217.00
IUUC-Dre-027492	Danio rerio	71.61	0.00e+00	1067.00
IUUC-Dno-030020	Dasypus novemcinctus	87.30	0.00e+00	2073.00
IUUC-Dor-031103	Dipodomys ordii	84.53	0.00e+00	2159.00
IUUC-Ete-032488	Echinops telfairi	81.82	0.00e+00	2138.00
IUUC-Eca-034066	Equus caballus	93.20	0.00e+00	2496.00
IUUC-Eeu-035199	Erinaceus europaeus	70.97	0.00e+00	756.00
IUUC-Fca-035434	Felis catus	87.19	0.00e+00	1987.00
IUUC-Fal-037113	Ficedula albicollis	79.09	0.00e+00	2160.00
IUUC-Gmo-039686	Gadus morhua	70.78	0.00e+00	1018.00
IUUC-Gga-040273	Gallus gallus	79.25	0.00e+00	2127.00
IUUC-Gac-042123	Gasterosteus aculeatus	50.98	0.00e+00	1256.00
IUUC-Ggo-044643	Gorilla gorilla	99.40	0.00e+00	2591.00
IUUC-Hsa-046380	Homo sapiens	99.63	0.00e+00	2563.00
IUUC-Itr-048658	Ictidomys tridecemlineatus	93.67	0.00e+00	1449.00
IUUC-Lch-050217	Latimeria chalumnae	67.24	0.00e+00	1755.00
IUUC-Lpe-051201	Leersia perrieri	28.48	8.00e-11	62.00
IUUC-Loc-052766	Lepisosteus oculatus	59.06	0.00e+00	1289.00
IUUC-Laf-053780	Loxodonta africana	89.54	0.00e+00	2424.00
IUUC-Mcc-054928	Macaca mulatta	98.65	0.00e+00	2576.00
IUUC-Meu-056184	Macropus eugenii	75.72	0.00e+00	795.00
IUUC-Mga-059576	Meleagris gallopavo	79.99	0.00e+00	2133.00
IUUC-Mmr-061045	Microcebus murinus	93.05	0.00e+00	2483.00
IUUC-Mdo-062576	Monodelphis domestica	83.27	0.00e+00	2223.00
IUUC-Mmu-063640	Mus musculus	91.04	0.00e+00	2383.00
IUUC-Mac-065303	Musa acuminata	29.22	3.00e-11	63.90
IUUC-Mpu-066512	Mustela putorius furo	92.64	0.00e+00	2428.00
IUUC-Mlu-067280	Myotis lucifugus	80.46	0.00e+00	1103.00
IUUC-Nle-069896	Nomascus leucogenys	99.61	0.00e+00	2467.00
IUUC-Ont-072197	Oreochromis niloticus	73.15	0.00e+00	1040.00
IUUC-Oan-072724	Ornithorhynchus anatinus	79.23	0.00e+00	1374.00
IUUC-Ocu-074758	Oryctolagus cuniculus	89.48	0.00e+00	2307.00
IUUC-Olo-080702	Oryza longistaminata	41.47	3.00e-45	177.00
IUUC-Opu-083371	Oryza punctata	41.88	1.00e-46	182.00
IUUC-Oga-088702	Otolemur garnettii	92.43	0.00e+00	2143.00
IUUC-Oar-089736	Ovis aries	81.20	0.00e+00	1990.00
IUUC-Ptr-091055	Pan troglodytes	99.48	0.00e+00	2561.00
IUUC-Pan-092752	Papio anubis	99.61	0.00e+00	1478.00
IUUC-Psi-093620	Pelodiscus sinensis	80.73	0.00e+00	2167.00
IUUC-Pfo-097464	Poecilia formosa	50.79	0.00e+00	1220.00
IUUC-Pop-099927	Populus trichocarpa	28.96	5.00e-12	66.60
IUUC-Pca-100273	Procavia capensis	89.16	0.00e+00	2366.00
IUUC-Pva-102473	Pteropus vampyrus	79.31	0.00e+00	1962.00
IUUC-Rno-105056	Rattus norvegicus	90.60	0.00e+00	2380.00
IUUC-Sha-107494	Sarcophilus harrisii	84.13	0.00e+00	2212.00
IUUC-Sar-113310	Sorex araneus	91.29	0.00e+00	1891.00
IUUC-Sbi-114581	Sorghum bicolor	35.19	5.00e-10	58.50
IUUC-Ssc-116344	Sus scrofa	85.85	0.00e+00	2259.00
IUUC-Tgu-116786	Taeniopygia guttata	80.78	0.00e+00	2162.00
IUUC-Tru-117638	Takifugu rubripes	51.32	0.00e+00	1244.00
IUUC-Tsy-118937	Tarsius syrichta	97.07	0.00e+00	1566.00
IUUC-Tni-120452	Tetraodon nigroviridis	54.21	0.00e+00	1182.00
IUUC-Tae-125237	Triticum aestivum	31.51	1.00e-07	50.10
IUUC-Tbe-127291	Tupaia belangeri	88.39	0.00e+00	1534.00
IUUC-Ttr-129017	Tursiops truncatus	83.63	0.00e+00	1787.00
IUUC-Xtr-132673	Xenopus tropicalis	67.55	0.00e+00	1787.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence