iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-054202

Ensembl Protein ID

ENSLAFP00000025323.1

UniProt Accession

G3UBW5; G3UBW5_LOXAF

Protein Name

Uncharacterized protein

Gene Name

HCLS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000014847.4	ENSLAFT00000031510.1	ENSLAFP00000025323.1
ENSLAFG00000014847.4	ENSLAFT00000014852.4	ENSLAFP00000012439.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.30e-11	42.4	436	486

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            +lydy+++ +de ++   d+++ i  e  degW++g    +g  GlfP+n+v+ 
   Q: 436  VALYDYQGEGSDEISFDPDDIITDI--EMVDEGWWRG--RCHGHFGLFPANYVKL 486
           68**********************9..9*********..8*************85 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK 60
VSEEHGILKK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAARGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGGAAGT CTGTAGTGGG GCACGATGTA TCTGTCTCTG TGGAGACCCA AGGGGATGAC 60
TGGGACACCG ACCCTGACTT TGTGGTGAGT TTGGAAATAG CTTTGCTCAG TTAAGGGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0009725--P:response to hormone

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001194	Ailuropoda melanoleuca	82.76	0.00e+00	708.00
IUUC-Ame-011504	Astyanax mexicanus	45.10	2.00e-100	359.00
IUUC-Bta-012591	Bos taurus	84.02	0.00e+00	678.00
IUUC-Cja-019982	Callithrix jacchus	81.26	0.00e+00	682.00
IUUC-Cfa-020262	Canis familiaris	82.32	0.00e+00	645.00
IUUC-Cpo-021362	Cavia porcellus	83.37	0.00e+00	644.00
IUUC-Csa-023911	Chlorocebus sabaeus	88.52	2.00e-166	578.00
IUUC-Dor-030437	Dipodomys ordii	74.85	2.00e-170	591.00
IUUC-Ete-033160	Echinops telfairi	74.95	6.00e-152	530.00
IUUC-Eca-033269	Equus caballus	81.38	0.00e+00	698.00
IUUC-Eeu-035032	Erinaceus europaeus	68.80	2.00e-118	419.00
IUUC-Fca-035999	Felis catus	80.76	0.00e+00	734.00
IUUC-Fal-037107	Ficedula albicollis	52.35	4.00e-122	431.00
IUUC-Gga-040335	Gallus gallus	67.38	3.00e-105	375.00
IUUC-Ggo-044505	Gorilla gorilla	87.43	6.00e-164	570.00
IUUC-Hsa-046728	Homo sapiens	86.87	7.00e-163	566.00
IUUC-Itr-048592	Ictidomys tridecemlineatus	72.66	2.00e-135	475.00
IUUC-Mcc-055824	Macaca mulatta	81.11	0.00e+00	674.00
IUUC-Mmr-061281	Microcebus murinus	74.18	5.00e-170	590.00
IUUC-Mdo-062515	Monodelphis domestica	68.98	2.00e-153	535.00
IUUC-Mmu-064341	Mus musculus	81.56	0.00e+00	695.00
IUUC-Mpu-066565	Mustela putorius furo	81.97	0.00e+00	676.00
IUUC-Mlu-066942	Myotis lucifugus	81.08	0.00e+00	670.00
IUUC-Nle-069436	Nomascus leucogenys	84.46	0.00e+00	675.00
IUUC-Opr-070288	Ochotona princeps	74.95	6.00e-160	556.00
IUUC-Ocu-074686	Oryctolagus cuniculus	79.27	5.00e-175	607.00
IUUC-Ola-086894	Oryzias latipes	58.95	1.00e-92	333.00
IUUC-Oga-088585	Otolemur garnettii	76.77	0.00e+00	665.00
IUUC-Oar-089686	Ovis aries	84.18	0.00e+00	699.00
IUUC-Ptr-090461	Pan troglodytes	87.71	2.00e-164	572.00
IUUC-Pan-091887	Papio anubis	88.27	3.00e-167	581.00
IUUC-Psi-093785	Pelodiscus sinensis	53.37	3.00e-141	495.00
IUUC-Pab-098222	Pongo abelii	86.87	9.00e-163	566.00
IUUC-Pca-100668	Procavia capensis	84.68	0.00e+00	686.00
IUUC-Pva-102767	Pteropus vampyrus	72.95	1.00e-163	568.00
IUUC-Rno-106001	Rattus norvegicus	81.97	0.00e+00	686.00
IUUC-Sar-113338	Sorex araneus	73.70	3.00e-165	574.00
IUUC-Ssc-116027	Sus scrofa	82.02	0.00e+00	705.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence