iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000235631.1	ENST00000434824.1	ENSP00000388207.1
ENSG00000235631.1	ENST00000447240.1	ENSP00000412846.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC
DNA & RNA Element
UTRdb	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	9.00e-06	27.8	258	299

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C++ +  +d +++l C+H+fh+ C+  w         + +CP C+
   Q: 258  CVVCFDTYkpQDVVRILTCKHFFHKACIDPW------LLAHRTCPMCK 299
           ******9977777******************......999*******6 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSFLRITPST HSSVSSGLLR LSIFLLLSFP DSNGKAIWTA HLNITFQVGN EITSELGESG 60
VFGNHSPLER VSGVVALPEG WNQNACHPLT NFSRPKQADS WLALIERGGC TFTHKINVAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTACCAATCA CAAGTCTTGT TATTTTGTTT CATTATGAGA AAGATAATCT ACTAAATATT 60
AAAATACTGG AAGGAGCAAG ATAGCTTTGA TCCAGGGAGA CCTTTTCCAT TTATGTGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003137--PA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF02225--PA
PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0008270--F:zinc ion binding

KEGG

hsa:378925

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001306	Ailuropoda melanoleuca	84.59	2.00e-136	478.00
IUUC-Cpo-022417	Cavia porcellus	79.20	8.00e-133	466.00
IUUC-Csa-024009	Chlorocebus sabaeus	93.11	4.00e-155	540.00
IUUC-Dno-029641	Dasypus novemcinctus	87.54	6.00e-150	523.00
IUUC-Eca-033938	Equus caballus	84.59	3.00e-145	507.00
IUUC-Ggo-044884	Gorilla gorilla	96.39	2.00e-168	584.00
IUUC-Kpa-049143	Komagataella pastoris	40.66	3.00e-12	66.60
IUUC-Mdo-062912	Monodelphis domestica	75.99	4.00e-131	461.00
IUUC-Mmu-063507	Mus musculus	81.58	4.00e-141	493.00
IUUC-Mlu-067519	Myotis lucifugus	82.62	1.00e-139	489.00
IUUC-Oga-089172	Otolemur garnettii	85.25	4.00e-148	517.00
IUUC-Oar-089296	Ovis aries	81.97	1.00e-142	498.00
IUUC-Rno-105562	Rattus norvegicus	84.33	6.00e-145	506.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence