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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064178
Ensembl Protein ID ENSMUSP00000019722.5
UniProt Accession Q99PL6; B8JJA5; Q3TTP1; Q3UG19; Q8C4D6; Q91W79; Q9D7L9; UBXN6_MOUSE
Genbank Protein ID AAK13259.1; BAB26082.1; BAC38512.1; BAE28390.1; BAE36284.1; EDL23709.1; CAX15602.1; AAH16412.1; AAH49963.1
Protein Name UBX domain-containing protein 6; UBX domain-containing protein 1
Genbank Nucleotide ID AF272895; AK009117; AK082510; AK148170; AK161273; CH466559; CT009719; BC016412; BC049963
Gene Name Ubxn6; Ubxd1; Ubxdc2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000019578.11 ENSMUST00000019722.11 ENSMUSP00000019722.5
ENSMUSG00000019578.11 ENSMUST00000139371.1 ENSMUSP00000120423.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
ULD/UDP/UFD/UBX 1.70e-11 45.6 334 408
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UFD/UBX
   S: 3    teqatlqiRlpdGkrlvrkFpssttleqiyqfveyllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsllv 79
           +++a +++RlpdG+ l+ +F ++++l++++ fv ++l++++ pFeL ++  +++ ++e     l+e+gLvps+ l++
   Q: 334  YTYALVRVRLPDGCLLQGTFYAREKLSALFRFVREALQNDWLPFELRASGGQKLEENEAL--ALNECGLVPSALLTF 408
           56899********************************************99886666666..***********9986 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation (By similarity).
 Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation (By similarity).
Protein Sequence
(Fasta)
MKKFFQEIKA DIKFKSAGPG QKLTDSAGEK TTKGKSPQLA LRQPRQGPTD EAQMAAAAAL 60
ARLEQKQPRA RGPTSQDSIR NQVRKELQAE ATSSNNPGAP GTNSVPEPKE EISPHLAVPG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064178|ULD,UBX|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGACTTCCGT CGCCGCGATA TTTTCTTTCC GGTGGTTGGC CGCCTGCTCC TCATCCACCC 60
GGGCCCTGCG CCCTCCGCCC TGCGGCCCAA GCCGCCGGGC CGCTGCCGCC ATGAAGAAGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064178|ULD,UBX|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR018997--PUB_domain
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom
PROSITE

PS50033--UBX
Pfam

PF09409--PUB
PF00789--UBX
SMART

SM00580--PUG
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005815--C:microtubule organizing center
GO:0005634--C:nucleus
KEGG mmu:66530
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001394 Ailuropoda melanoleuca 81.16 0.00e+00 660.00
IUUC-Atr-002503 Amborella trichopoda 27.46 3.00e-24 106.00
IUUC-Apl-003287 Anas platyrhynchos 62.22 2.00e-123 435.00
IUUC-Aca-004441 Anolis carolinensis 67.28 7.00e-148 516.00
IUUC-Aly-005477 Arabidopsis lyrata 28.33 2.00e-16 80.50
IUUC-Ath-007053 Arabidopsis thaliana 30.00 7.00e-16 78.60
IUUC-Ame-011784 Astyanax mexicanus 56.88 2.00e-123 435.00
IUUC-Bta-012994 Bos taurus 81.63 0.00e+00 698.00
IUUC-Bdi-014901 Brachypodium distachyon 30.74 3.00e-24 106.00
IUUC-Bol-016357 Brassica oleracea 32.70 5.00e-18 85.90
IUUC-Bra-017774 Brassica rapa 32.57 5.00e-19 89.00
IUUC-Cel-018297 Caenorhabditis elegans 31.05 6.00e-37 148.00
IUUC-Cja-019065 Callithrix jacchus 78.28 0.00e+00 671.00
IUUC-Cfa-020323 Canis familiaris 78.46 0.00e+00 675.00
IUUC-Cpo-022404 Cavia porcellus 79.51 0.00e+00 687.00
IUUC-Csa-023284 Chlorocebus sabaeus 81.90 0.00e+00 709.00
IUUC-Cin-025536 Ciona intestinalis 32.39 2.00e-42 166.00
IUUC-Csv-026209 Ciona savignyi 35.02 6.00e-31 127.00
IUUC-Dre-028550 Danio rerio 53.36 2.00e-103 369.00
IUUC-Dno-029718 Dasypus novemcinctus 73.36 9.00e-166 576.00
IUUC-Dor-030284 Dipodomys ordii 77.94 1.00e-177 615.00
IUUC-Dme-031962 Drosophila melanogaster 37.37 2.00e-49 189.00
IUUC-Ete-032636 Echinops telfairi 68.28 4.00e-69 255.00
IUUC-Eca-033672 Equus caballus 80.00 7.00e-155 539.00
IUUC-Fca-036036 Felis catus 86.55 1.00e-57 214.00
IUUC-Fal-037624 Ficedula albicollis 60.38 4.00e-108 384.00
IUUC-Gmo-039105 Gadus morhua 52.39 9.00e-106 377.00
IUUC-Gga-040449 Gallus gallus 62.44 3.00e-142 498.00
IUUC-Gac-042028 Gasterosteus aculeatus 52.46 8.00e-104 370.00
IUUC-Gma-042762 Glycine max 31.46 2.00e-19 90.50
IUUC-Ggo-044540 Gorilla gorilla 81.40 0.00e+00 653.00
IUUC-Hsa-045728 Homo sapiens 80.95 0.00e+00 694.00
IUUC-Hvu-047208 Hordeum vulgare 36.60 2.00e-19 88.60
IUUC-Itr-048940 Ictidomys tridecemlineatus 81.94 0.00e+00 706.00
IUUC-Lch-050216 Latimeria chalumnae 59.50 1.00e-133 469.00
IUUC-Lpe-051136 Leersia perrieri 30.12 1.00e-25 111.00
IUUC-Loc-052086 Lepisosteus oculatus 57.11 1.00e-110 392.00
IUUC-Laf-053998 Loxodonta africana 73.03 0.00e+00 641.00
IUUC-Mcc-055877 Macaca mulatta 81.90 0.00e+00 709.00
IUUC-Meu-056058 Macropus eugenii 53.62 1.00e-110 393.00
IUUC-Mtr-058198 Medicago truncatula 30.88 7.00e-21 95.10
IUUC-Mga-060105 Meleagris gallopavo 63.12 2.00e-147 515.00
IUUC-Mmr-061059 Microcebus murinus 81.00 0.00e+00 714.00
IUUC-Mdo-061899 Monodelphis domestica 72.85 2.00e-176 611.00
IUUC-Mac-064698 Musa acuminata 33.33 2.00e-25 109.00
IUUC-Mpu-065804 Mustela putorius furo 82.13 0.00e+00 721.00
IUUC-Mlu-067204 Myotis lucifugus 79.64 0.00e+00 667.00
IUUC-Nle-069663 Nomascus leucogenys 81.00 0.00e+00 701.00
IUUC-Opr-071214 Ochotona princeps 81.01 2.00e-161 561.00
IUUC-Ont-071987 Oreochromis niloticus 53.38 7.00e-98 350.00
IUUC-Oan-073484 Ornithorhynchus anatinus 55.76 2.00e-104 373.00
IUUC-Ocu-073988 Oryctolagus cuniculus 59.95 6.00e-107 380.00
IUUC-Oba-075124 Oryza barthii 36.60 4.00e-20 91.30
IUUC-Obr-076731 Oryza brachyantha 31.70 1.00e-24 107.00
IUUC-Ogl-077903 Oryza glaberrima 36.18 2.00e-17 82.40
IUUC-Ogu-078325 Oryza glumaepatula 31.23 1.00e-26 114.00
IUUC-Oin-079788 Oryza indica 31.10 4.00e-21 95.50
IUUC-Ome-081645 Oryza meridionalis 31.23 6.00e-26 112.00
IUUC-Oni-082890 Oryza nivara 31.97 1.00e-26 114.00
IUUC-Opu-083357 Oryza punctata 30.86 1.00e-25 110.00
IUUC-Oru-084284 Oryza rufipogon 30.86 2.00e-26 113.00
IUUC-Osa-086240 Oryza sativa 36.60 4.00e-20 91.30
IUUC-Ola-087409 Oryzias latipes 52.77 1.00e-99 356.00
IUUC-Oga-089065 Otolemur garnettii 82.39 0.00e+00 723.00
IUUC-Oar-090352 Ovis aries 80.34 0.00e+00 648.00
IUUC-Ptr-091500 Pan troglodytes 80.77 0.00e+00 683.00
IUUC-Pan-092827 Papio anubis 81.90 0.00e+00 709.00
IUUC-Psi-093445 Pelodiscus sinensis 65.71 3.00e-142 498.00
IUUC-Pfo-096895 Poecilia formosa 57.63 7.00e-74 270.00
IUUC-Pab-098545 Pongo abelii 79.86 0.00e+00 676.00
IUUC-Pop-099215 Populus trichocarpa 29.41 2.00e-23 103.00
IUUC-Pca-100335 Procavia capensis 81.45 0.00e+00 717.00
IUUC-Ppe-101911 Prunus persica 25.88 1.00e-21 97.80
IUUC-Pva-103169 Pteropus vampyrus 70.14 4.00e-159 554.00
IUUC-Rno-106064 Rattus norvegicus 97.96 0.00e+00 832.00
IUUC-Sha-107437 Sarcophilus harrisii 73.98 1.00e-50 191.00
IUUC-Sit-110426 Setaria italica 29.74 3.00e-23 102.00
IUUC-Sly-111225 Solanum lycopersicum 32.16 5.00e-21 95.50
IUUC-Stu-112826 Solanum tuberosum 28.39 4.00e-21 95.90
IUUC-Sar-113312 Sorex araneus 78.98 9.00e-127 446.00
IUUC-Sbi-114391 Sorghum bicolor 30.60 1.00e-23 103.00
IUUC-Sre-114935 Sporisorium reilianum 25.77 5.00e-06 45.10
IUUC-Ssc-115396 Sus scrofa 83.22 0.00e+00 691.00
IUUC-Tgu-116843 Taeniopygia guttata 62.50 7.00e-116 410.00
IUUC-Tru-118747 Takifugu rubripes 53.36 3.00e-100 358.00
IUUC-Tni-120834 Tetraodon nigroviridis 53.15 1.00e-99 356.00
IUUC-Tca-121181 Theobroma cacao 28.23 2.00e-19 90.10
IUUC-Tae-122844 Triticum aestivum 30.37 3.00e-24 106.00
IUUC-Tur-126442 Triticum urartu 30.37 3.00e-24 105.00
IUUC-Tbe-127541 Tupaia belangeri 69.23 6.00e-147 513.00
IUUC-Ttr-129191 Tursiops truncatus 80.95 0.00e+00 688.00
IUUC-Uma-129497 Ustilago maydis 25.93 1.00e-04 40.40
IUUC-Vvi-130861 Vitis vinifera 31.92 2.00e-21 97.10
IUUC-Xtr-132485 Xenopus tropicalis 54.50 8.00e-123 433.00
IUUC-Xma-133953 Xiphophorus maculatus 55.32 1.00e-90 326.00
Created Date 25-Jun-2017

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