iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-090766

Ensembl Protein ID

ENSPTRP00000017657.3

UniProt Accession

H2QF58; H2QF58_PANTR

Genbank Protein ID

ENSPTRP00000017657

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03120856

Gene Name

VAV1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000010378.3	ENSPTRT00000019074.3	ENSPTRP00000017657.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.60e-21	74.5	720	771

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+lk+Gd+++++ +++  +gW++g  e  g+ G fP+n+ve+
   Q: 720  KARYDFCARDRSELSLKEGDIIKIL-NKKGQQGWWRG--EIYGRVGWFPANYVEE 771
           788**********************.89999******..9*************86 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

FLCLKNIRTF LSTCCEKFGL KRSELFEAFD LFDVQDFGKV IYTLSALSWT PIAQNRGIMP 60
FPTEEESVGD EDIYSGLSDQ IDDTVEEDED LYDCVENEEA EGDEIYEDLM RSEPVSMPPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCACAGTTCC TGTGCCTTAA GAACATTAGA ACCTTCCTGT CCACCTGCTG TGAGAAGTTC 60
GGCCTCAAGC GGAGCGAGCT CTTCGAAGCC TTTGACCTCT TCGATGTGCA GGATTTTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR001452--SH3_domain
IPR028530--Vav

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030593--P:neutrophil chemotaxis
GO:0006909--P:phagocytosis
GO:0045785--P:positive regulation of cell adhesion
GO:0045954--P:positive regulation of natural killer cell mediated cytotoxicity
GO:0072593--P:reactive oxygen species metabolic process
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013049	Bos taurus	80.96	0.00e+00	1247.00
IUUC-Cja-020009	Callithrix jacchus	98.07	0.00e+00	1568.00
IUUC-Cfa-020768	Canis familiaris	95.88	0.00e+00	1488.00
IUUC-Dno-029602	Dasypus novemcinctus	94.21	0.00e+00	1485.00
IUUC-Eca-033682	Equus caballus	95.37	0.00e+00	1495.00
IUUC-Fca-035629	Felis catus	94.86	0.00e+00	1548.00
IUUC-Gmo-039693	Gadus morhua	58.10	0.00e+00	872.00
IUUC-Gac-041567	Gasterosteus aculeatus	64.24	0.00e+00	918.00
IUUC-Hsa-045886	Homo sapiens	100.00	0.00e+00	1596.00
IUUC-Itr-048730	Ictidomys tridecemlineatus	89.72	0.00e+00	1389.00
IUUC-Loc-051761	Lepisosteus oculatus	71.41	0.00e+00	1108.00
IUUC-Laf-054537	Loxodonta africana	94.21	0.00e+00	1490.00
IUUC-Mcc-054726	Macaca mulatta	98.84	0.00e+00	1582.00
IUUC-Mmr-060980	Microcebus murinus	93.83	0.00e+00	1496.00
IUUC-Mdo-061926	Monodelphis domestica	86.36	0.00e+00	1335.00
IUUC-Mmu-063942	Mus musculus	92.79	0.00e+00	1470.00
IUUC-Mpu-066000	Mustela putorius furo	95.88	0.00e+00	1490.00
IUUC-Mlu-067818	Myotis lucifugus	92.19	0.00e+00	1451.00
IUUC-Ont-072213	Oreochromis niloticus	66.03	0.00e+00	1023.00
IUUC-Ocu-074830	Oryctolagus cuniculus	78.47	0.00e+00	1182.00
IUUC-Ola-087345	Oryzias latipes	62.61	0.00e+00	968.00
IUUC-Oga-089104	Otolemur garnettii	95.75	0.00e+00	1514.00
IUUC-Oar-089459	Ovis aries	94.21	0.00e+00	1498.00
IUUC-Pan-091994	Papio anubis	97.94	0.00e+00	1562.00
IUUC-Psi-093595	Pelodiscus sinensis	78.53	0.00e+00	1196.00
IUUC-Pfo-097210	Poecilia formosa	64.50	0.00e+00	977.00
IUUC-Pab-098630	Pongo abelii	99.47	0.00e+00	1551.00
IUUC-Pva-102406	Pteropus vampyrus	93.82	0.00e+00	1435.00
IUUC-Pte-104123	Pyrenophora teres	47.46	2.00e-10	61.60
IUUC-Rno-105763	Rattus norvegicus	89.45	0.00e+00	1404.00
IUUC-Sha-106683	Sarcophilus harrisii	85.73	0.00e+00	1409.00
IUUC-Sly-111123	Solanum lycopersicum	50.00	1.00e-09	57.40
IUUC-Stu-112434	Solanum tuberosum	50.00	1.00e-09	57.40
IUUC-Sar-113457	Sorex araneus	79.73	0.00e+00	939.00
IUUC-Ssc-115338	Sus scrofa	95.75	0.00e+00	1533.00
IUUC-Tru-118199	Takifugu rubripes	62.80	0.00e+00	919.00
IUUC-Tni-120548	Tetraodon nigroviridis	63.20	0.00e+00	944.00
IUUC-Tbe-127235	Tupaia belangeri	71.23	4.00e-139	488.00
IUUC-Ttr-128916	Tursiops truncatus	88.43	0.00e+00	960.00
IUUC-Vpa-130066	Vicugna pacos	69.86	7.00e-83	301.00
IUUC-Xtr-132410	Xenopus tropicalis	71.39	0.00e+00	1139.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence