iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090306

Ensembl Protein ID

ENSOARP00000001796.1

UniProt Accession

W5NUF2; W5NUF2_SHEEP

Genbank Protein ID

ENSOARP00000001796

Protein Name

Phosphoinositide phospholipase C

Genbank Nucleotide ID

AMGL01026080

Gene Name

PLCG1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000001700.1	ENSOART00000001840.1	ENSOARP00000001796.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.00e-12	45.8	704	761

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGl.fPenFvekl 62
           +k  v++l+dy+aq +deLt++k  +++ +  e+q++gW++g  +  gk+ l fP+n+ve++
   Q: 704  FKCAVKALFDYKAQREDELTFTKSAIIQNV--EKQEGGWWRG--DYGGKKQLwFPSNYVEEM 761
           56789************************9..9*********..676666655******985 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

VDIREIKEIR PGKTSRDFDR YQEDPAFRPD QSHCFVILYG MEFRLKTLSL QATSEDEVNM 60
WIKGLTWLME DTLQAATPLQ IERWLRKQFY SVDRNREDRI SAKDLKNMLS QVNYRVPNMR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGACATTC GTGAAATCAA GGAGATCCGC CCAGGGAAGA CCTCACGGGA CTTCGATCGC 60
TACCAAGAGG ATCCTGCTTT TCGACCAGAC CAGTCCCACT GCTTCGTCAT CCTGTACGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028380--PLC-gamma1
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00233--PH
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0005829--C:cytosol
GO:0030027--C:lamellipodium
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0005509--F:calcium ion binding
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0019722--P:calcium-mediated signaling
GO:0016477--P:cell migration
GO:0071364--P:cellular response to epidermal growth factor stimulus
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0001701--P:in utero embryonic development
GO:0009395--P:phospholipid catabolic process
GO:0045766--P:positive regulation of angiogenesis
GO:0043536--P:positive regulation of blood vessel endothelial cell migration
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:0050852--P:T cell receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001452	Ailuropoda melanoleuca	94.75	0.00e+00	2363.00
IUUC-Apl-003541	Anas platyrhynchos	67.16	0.00e+00	1630.00
IUUC-Aca-005291	Anolis carolinensis	84.19	0.00e+00	2081.00
IUUC-Ame-011004	Astyanax mexicanus	66.35	0.00e+00	1637.00
IUUC-Bta-012660	Bos taurus	96.15	0.00e+00	2397.00
IUUC-Cja-019206	Callithrix jacchus	94.01	0.00e+00	2351.00
IUUC-Cfa-020257	Canis familiaris	95.16	0.00e+00	2374.00
IUUC-Cpo-022391	Cavia porcellus	88.75	0.00e+00	2184.00
IUUC-Csa-024170	Chlorocebus sabaeus	95.03	0.00e+00	1692.00
IUUC-Cin-025520	Ciona intestinalis	46.49	0.00e+00	1016.00
IUUC-Dre-027944	Danio rerio	70.47	0.00e+00	1736.00
IUUC-Dno-029440	Dasypus novemcinctus	93.73	0.00e+00	2258.00
IUUC-Dor-031001	Dipodomys ordii	93.45	0.00e+00	2351.00
IUUC-Eca-033809	Equus caballus	95.16	0.00e+00	2383.00
IUUC-Fca-036510	Felis catus	94.26	0.00e+00	2362.00
IUUC-Fal-037541	Ficedula albicollis	85.10	0.00e+00	2026.00
IUUC-Gmo-038630	Gadus morhua	66.73	0.00e+00	1330.00
IUUC-Gga-040142	Gallus gallus	85.98	0.00e+00	2130.00
IUUC-Ggo-045063	Gorilla gorilla	94.26	0.00e+00	2364.00
IUUC-Hsa-046428	Homo sapiens	94.18	0.00e+00	2362.00
IUUC-Itr-048245	Ictidomys tridecemlineatus	93.85	0.00e+00	2358.00
IUUC-Lch-049766	Latimeria chalumnae	78.15	0.00e+00	1908.00
IUUC-Loc-052285	Lepisosteus oculatus	74.86	0.00e+00	1880.00
IUUC-Laf-053365	Loxodonta africana	93.54	0.00e+00	2338.00
IUUC-Mcc-054871	Macaca mulatta	93.28	0.00e+00	2334.00
IUUC-Meu-056724	Macropus eugenii	86.00	0.00e+00	2120.00
IUUC-Mga-059329	Meleagris gallopavo	84.98	0.00e+00	2095.00
IUUC-Mmr-061110	Microcebus murinus	93.77	0.00e+00	2340.00
IUUC-Mdo-062448	Monodelphis domestica	91.23	0.00e+00	2306.00
IUUC-Mmu-063565	Mus musculus	94.20	0.00e+00	2346.00
IUUC-Mpu-066683	Mustela putorius furo	94.67	0.00e+00	2369.00
IUUC-Mlu-067779	Myotis lucifugus	93.61	0.00e+00	2341.00
IUUC-Nle-069219	Nomascus leucogenys	94.70	0.00e+00	2056.00
IUUC-Opr-070766	Ochotona princeps	91.91	0.00e+00	1427.00
IUUC-Ont-072524	Oreochromis niloticus	72.26	0.00e+00	1803.00
IUUC-Oan-073214	Ornithorhynchus anatinus	87.76	9.00e-47	178.00
IUUC-Ocu-074361	Oryctolagus cuniculus	92.57	0.00e+00	2311.00
IUUC-Ola-086820	Oryzias latipes	71.57	0.00e+00	1823.00
IUUC-Oga-088172	Otolemur garnettii	94.26	0.00e+00	2363.00
IUUC-Ptr-090682	Pan troglodytes	94.18	0.00e+00	2363.00
IUUC-Pan-092835	Papio anubis	95.64	0.00e+00	1803.00
IUUC-Psi-093344	Pelodiscus sinensis	83.69	0.00e+00	2092.00
IUUC-Pfo-096984	Poecilia formosa	70.06	0.00e+00	1762.00
IUUC-Pab-097871	Pongo abelii	93.93	0.00e+00	2360.00
IUUC-Pca-100772	Procavia capensis	87.30	0.00e+00	2149.00
IUUC-Pva-102790	Pteropus vampyrus	95.35	0.00e+00	2314.00
IUUC-Rno-105974	Rattus norvegicus	93.93	0.00e+00	2361.00
IUUC-Sar-112995	Sorex araneus	92.06	0.00e+00	2292.00
IUUC-Ssc-115360	Sus scrofa	94.67	0.00e+00	2370.00
IUUC-Tgu-116585	Taeniopygia guttata	83.03	0.00e+00	2000.00
IUUC-Tru-117742	Takifugu rubripes	71.69	0.00e+00	1823.00
IUUC-Tsy-119259	Tarsius syrichta	97.62	0.00e+00	859.00
IUUC-Tni-120833	Tetraodon nigroviridis	65.56	0.00e+00	1587.00
IUUC-Tbe-127504	Tupaia belangeri	88.72	0.00e+00	1274.00
IUUC-Ttr-128650	Tursiops truncatus	94.11	0.00e+00	1132.00
IUUC-Xtr-132862	Xenopus tropicalis	75.33	0.00e+00	1830.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence