iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000008112.3	ENSMMUT00000011335.3	ENSMMUP00000010623.3
ENSMMUG00000008112.3	ENSMMUT00000011336.3	ENSMMUP00000010624.3
ENSMMUG00000008112.3	ENSMMUT00000040532.2	ENSMMUP00000033589.2
ENSMMUG00000008112.3	ENSMMUT00000040533.2	ENSMMUP00000033590.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.20e-135	451.3	987	1316

Active Site

Position(s)	Description	Evidence
1286	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 987  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDG 1073
           5899*********************************************************************************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           ++ ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk gG++i Vtn+Nk+eY+ lv
   Q: 1074 FFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLV 1155
           ***********************************99...6666..7**************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           +++r+ ++i++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy++++++iqwFw+++ +++se+r ++
   Q: 1156 IQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRL 1242
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           LqFvTg+sr+P++Gfael     p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 1243 LQFVTGTSRVPMNGFAELYgsngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 1316
           *************************************************************************8 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAQSLRLHFA ARRSNTYPLS ETSGDDLDSH VHMCFKRPTR ISASNVVQMK LTPRQTALAP 60
LIKENVQSQE RSSVPSSENV NKKSSCLQIS LQPTRYSGYL QSSNVLADSE DASFTCILKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCCCGCGGC GCTGCCGGGT GCAGCTAGCG CCCACTCGCC GGGGGAGGCG CTGCTGTCGC 60
TGGGGGAGCG CCTCCTCCTC TTCCTCCAAC TCTTCCCCGC CTCCTCCCGC TTCTCCTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

mcc:699550

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	91.08	0.00e+00	2358.00
IUUC-Apl-003886	Anas platyrhynchos	76.19	0.00e+00	1261.00
IUUC-Ame-011138	Astyanax mexicanus	83.96	0.00e+00	853.00
IUUC-Bta-012453	Bos taurus	89.54	0.00e+00	2273.00
IUUC-Cja-019034	Callithrix jacchus	96.66	0.00e+00	1439.00
IUUC-Cfa-020258	Canis familiaris	91.53	0.00e+00	2295.00
IUUC-Cpo-021648	Cavia porcellus	91.28	0.00e+00	1477.00
IUUC-Csa-023334	Chlorocebus sabaeus	99.75	0.00e+00	1532.00
IUUC-Cho-024672	Choloepus hoffmanni	83.72	0.00e+00	727.00
IUUC-Cin-025157	Ciona intestinalis	67.14	0.00e+00	796.00
IUUC-Dno-029159	Dasypus novemcinctus	90.34	0.00e+00	1328.00
IUUC-Dor-030729	Dipodomys ordii	79.85	0.00e+00	1039.00
IUUC-Dme-032166	Drosophila melanogaster	67.99	0.00e+00	713.00
IUUC-Ete-032409	Echinops telfairi	86.77	0.00e+00	1198.00
IUUC-Eca-033441	Equus caballus	95.77	0.00e+00	1450.00
IUUC-Eeu-034546	Erinaceus europaeus	75.45	0.00e+00	1182.00
IUUC-Fca-036384	Felis catus	91.47	0.00e+00	2338.00
IUUC-Fal-037547	Ficedula albicollis	81.39	0.00e+00	1288.00
IUUC-Gmo-039679	Gadus morhua	67.29	0.00e+00	1088.00
IUUC-Gga-040524	Gallus gallus	82.51	0.00e+00	1294.00
IUUC-Hsa-046479	Homo sapiens	97.88	0.00e+00	2497.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	83.93	0.00e+00	1194.00
IUUC-Lch-050445	Latimeria chalumnae	60.59	0.00e+00	1471.00
IUUC-Loc-052645	Lepisosteus oculatus	72.73	0.00e+00	1187.00
IUUC-Laf-053638	Loxodonta africana	84.04	0.00e+00	1351.00
IUUC-Meu-056897	Macropus eugenii	95.47	2.00e-171	596.00
IUUC-Mga-059362	Meleagris gallopavo	75.20	0.00e+00	1262.00
IUUC-Mmr-061061	Microcebus murinus	93.26	0.00e+00	2355.00
IUUC-Mmu-063318	Mus musculus	80.07	0.00e+00	1247.00
IUUC-Mpu-066567	Mustela putorius furo	94.92	0.00e+00	1531.00
IUUC-Mlu-068148	Myotis lucifugus	89.05	0.00e+00	2273.00
IUUC-Nle-069225	Nomascus leucogenys	97.73	0.00e+00	2472.00
IUUC-Oan-073019	Ornithorhynchus anatinus	86.21	0.00e+00	1394.00
IUUC-Ocu-074409	Oryctolagus cuniculus	89.33	0.00e+00	2263.00
IUUC-Oga-088241	Otolemur garnettii	87.75	0.00e+00	2153.00
IUUC-Oar-089797	Ovis aries	95.65	0.00e+00	1491.00
IUUC-Ptr-091629	Pan troglodytes	97.33	0.00e+00	1413.00
IUUC-Pan-092285	Papio anubis	100.00	0.00e+00	1010.00
IUUC-Psi-093618	Pelodiscus sinensis	68.34	0.00e+00	1620.00
IUUC-Pab-098394	Pongo abelii	98.63	0.00e+00	1539.00
IUUC-Pca-100568	Procavia capensis	78.58	0.00e+00	1137.00
IUUC-Rno-106095	Rattus norvegicus	79.95	0.00e+00	1270.00
IUUC-Sha-107370	Sarcophilus harrisii	67.92	0.00e+00	1739.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	51.07	1.00e-157	550.00
IUUC-Sre-114929	Sporisorium reilianum	47.35	1.00e-153	536.00
IUUC-Tgu-117474	Taeniopygia guttata	81.89	0.00e+00	1296.00
IUUC-Tru-117675	Takifugu rubripes	64.96	0.00e+00	1055.00
IUUC-Tbe-127408	Tupaia belangeri	86.68	0.00e+00	1160.00
IUUC-Ttr-128437	Tursiops truncatus	85.39	0.00e+00	1177.00
IUUC-Vpa-130503	Vicugna pacos	89.15	0.00e+00	1290.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence