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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064330
UUCD1 version UUC-MuM-01009
Ensembl Protein ID ENSMUSP00000030284.3
UniProt Accession Q9QYK7; B1AU36; B1AU37; Q9EQI1; RNF11_MOUSE
Genbank Protein ID BAA84682.1; AAG44245.1; CAM13662.1; CAM13663.1; EDL30703.1; EDL30704.1; EDL30705.1; AAH10299.1; AAH28255.1
Protein Name RING finger protein 11; NEDD4 WW domain-binding protein 2; Sid 1669
Genbank Nucleotide ID AB024427; AF220206; AL669905; AL669905; CH466527; CH466527; CH466527; BC010299; BC028255
Gene Name Rnf11; N4wbp2; Sid1669
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028557.10 ENSMUST00000030284.9 ENSMUSP00000030284.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 1.50e-08 36.1 99 139
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C iC+ df   d+ ++lpC H++h+dC+  w       +++f+CP C
   Q: 99   CVICMMDFvyGDPIRFLPCMHIYHLDCIDDW------LMRSFTCPSC 139
           ********99888******************......********** PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Interacts (when phosphorylated) with 14-3-3. Interacts with the E3 ubiquitin-ligases NEDD4, ITCH, SMURF2 and WWP1 (By similarity). Also interacts with the E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2N, but neither with CDC34, nor with UBE2L3. Interacts with ZNF350, EPS15 and STAMBP (By similarity). After TNF stimulation, interacts with TAX1BP1, TNFAIP3 and RIPK1; these interaction are transient and they are lost after 1 hour of stimulation with TNF. Interacts with GGA1 (By similarity).
 Interacts (when phosphorylated) with 14-3-3. Interacts with the E3 ubiquitin-ligases NEDD4, ITCH, SMURF2 and WWP1 (By similarity). Also interacts with the E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2N, but neither with CDC34, nor with UBE2L3. Interacts with ZNF350, EPS15 and STAMBP (By similarity). After TNF stimulation, interacts with TAX1BP1, TNFAIP3 and RIPK1; these interaction are transient and they are lost after 1 hour of stimulation with TNF. Interacts with GGA1 (By similarity).
Protein Sequence
(Fasta)
MGNCLKSPTS DDISLLHESQ SDRASFGEGT EPDQEPPPPY QEQVPVPIYH PTPSQTRLAT 60
QLTEEEQIRI AQRIGLIQHL PKGVYDPGRD GSEKKIRECV ICMMDFVYGD PIRFLPCMHI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064330|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTGCAGCAA TAGCCTGGGC AAAGGTCCTA CTTGAGCCAC AGGCCTTTTT AAATGCTACC 60
ATAACTCCTT AGAGCAAAGA GGTAAGTTGG ATGGAGAAAA GGCAGTTTGG TACTGGTATG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064330|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0449--Lipoprotein
KW-0479--Metal-binding
KW-0519--Myristate
KW-0539--Nucleus
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0055037--C:recycling endosome
GO:0000151--C:ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:29864
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001762 Ailuropoda melanoleuca 98.70 8.00e-77 278.00
IUUC-Apl-003879 Anas platyrhynchos 99.12 1.00e-64 237.00
IUUC-Aca-004887 Anolis carolinensis 98.05 2.00e-73 267.00
IUUC-Ame-011194 Astyanax mexicanus 92.21 3.00e-76 276.00
IUUC-Bta-013543 Bos taurus 99.13 6.00e-66 241.00
IUUC-Bol-016328 Brassica oleracea 44.78 2.00e-12 65.10
IUUC-Cel-018152 Caenorhabditis elegans 37.01 2.00e-22 98.60
IUUC-Cja-019172 Callithrix jacchus 99.35 3.00e-74 270.00
IUUC-Cfa-020423 Canis familiaris 99.11 6.00e-64 235.00
IUUC-Cpo-021457 Cavia porcellus 99.35 3.00e-74 270.00
IUUC-Csa-024165 Chlorocebus sabaeus 99.35 3.00e-74 270.00
IUUC-Cho-024439 Choloepus hoffmanni 90.97 2.00e-73 267.00
IUUC-Cin-025246 Ciona intestinalis 79.66 4.00e-25 105.00
IUUC-Csv-026239 Ciona savignyi 61.76 4.00e-35 140.00
IUUC-Dre-027392 Danio rerio 92.86 7.00e-76 275.00
IUUC-Dno-029468 Dasypus novemcinctus 99.12 1.00e-64 237.00
IUUC-Dor-030265 Dipodomys ordii 99.35 3.00e-74 270.00
IUUC-Dme-032121 Drosophila melanogaster 53.25 2.00e-41 161.00
IUUC-Ete-032526 Echinops telfairi 99.35 3.00e-74 270.00
IUUC-Eca-033516 Equus caballus 91.28 2.00e-64 237.00
IUUC-Eeu-035261 Erinaceus europaeus 99.12 1.00e-64 237.00
IUUC-Fca-036029 Felis catus 99.35 3.00e-74 270.00
IUUC-Fal-036620 Ficedula albicollis 98.26 1.00e-65 240.00
IUUC-Gmo-038539 Gadus morhua 92.21 8.00e-76 275.00
IUUC-Gga-040240 Gallus gallus 97.40 5.00e-73 266.00
IUUC-Gac-041863 Gasterosteus aculeatus 92.21 3.00e-75 273.00
IUUC-Ggo-045517 Gorilla gorilla 99.35 3.00e-74 270.00
IUUC-Hsa-046313 Homo sapiens 99.35 3.00e-74 270.00
IUUC-Itr-048979 Ictidomys tridecemlineatus 98.70 8.00e-74 268.00
IUUC-Lch-050201 Latimeria chalumnae 90.00 4.00e-63 233.00
IUUC-Loc-052731 Lepisosteus oculatus 90.45 2.00e-72 264.00
IUUC-Laf-053374 Loxodonta africana 99.12 3.00e-65 239.00
IUUC-Mcc-055336 Macaca mulatta 99.35 3.00e-74 270.00
IUUC-Meu-055960 Macropus eugenii 98.23 3.00e-64 236.00
IUUC-Mla-059167 Melampsora laricipopulina 45.61 1.00e-09 58.50
IUUC-Mga-059363 Meleagris gallopavo 99.12 1.00e-64 237.00
IUUC-Mmr-061651 Microcebus murinus 99.35 3.00e-74 270.00
IUUC-Mdo-062780 Monodelphis domestica 97.78 4.00e-61 226.00
IUUC-Mpu-065844 Mustela putorius furo 99.35 3.00e-74 270.00
IUUC-Mlu-067557 Myotis lucifugus 99.35 3.00e-74 270.00
IUUC-Nle-069160 Nomascus leucogenys 99.12 1.00e-64 237.00
IUUC-Opr-070708 Ochotona princeps 92.86 5.00e-70 256.00
IUUC-Ont-071784 Oreochromis niloticus 92.26 2.00e-75 274.00
IUUC-Oan-073071 Ornithorhynchus anatinus 90.70 8.00e-66 241.00
IUUC-Ocu-074236 Oryctolagus cuniculus 99.35 3.00e-74 270.00
IUUC-Ola-086848 Oryzias latipes 91.56 2.00e-83 301.00
IUUC-Oga-088630 Otolemur garnettii 70.78 1.00e-58 218.00
IUUC-Oar-089615 Ovis aries 99.35 3.00e-74 270.00
IUUC-Ptr-091459 Pan troglodytes 99.35 3.00e-74 270.00
IUUC-Pan-092848 Papio anubis 99.35 3.00e-74 270.00
IUUC-Psi-092968 Pelodiscus sinensis 98.05 2.00e-73 267.00
IUUC-Pfo-096923 Poecilia formosa 92.86 1.00e-84 304.00
IUUC-Pab-098483 Pongo abelii 99.35 3.00e-74 270.00
IUUC-Pca-100978 Procavia capensis 62.99 4.00e-41 160.00
IUUC-Pva-102550 Pteropus vampyrus 99.35 3.00e-74 270.00
IUUC-Ptt-103856 Puccinia triticina 45.10 2.00e-04 37.70
IUUC-Rno-105946 Rattus norvegicus 97.40 4.00e-71 259.00
IUUC-Sha-106723 Sarcophilus harrisii 98.25 7.00e-65 238.00
IUUC-Stu-112368 Solanum tuberosum 45.59 4.00e-13 67.80
IUUC-Sar-113209 Sorex araneus 99.35 3.00e-74 270.00
IUUC-Ssc-115813 Sus scrofa 99.35 3.00e-74 270.00
IUUC-Tgu-117220 Taeniopygia guttata 99.12 3.00e-65 239.00
IUUC-Tru-118754 Takifugu rubripes 92.86 8.00e-77 278.00
IUUC-Tsy-118863 Tarsius syrichta 99.12 1.00e-64 237.00
IUUC-Tni-119702 Tetraodon nigroviridis 92.21 2.00e-76 277.00
IUUC-Tbe-127266 Tupaia belangeri 98.97 7.00e-38 147.00
IUUC-Ttr-128337 Tursiops truncatus 99.35 3.00e-74 270.00
IUUC-Vpa-130786 Vicugna pacos 99.12 1.00e-64 237.00
IUUC-Xtr-132840 Xenopus tropicalis 94.81 6.00e-76 275.00
IUUC-Xma-134249 Xiphophorus maculatus 93.51 1.00e-84 305.00
Created Date 25-Jun-2017

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