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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-104992
UUCD1 version UUC-RaN-00908
Ensembl Protein ID ENSRNOP00000011663.3
UniProt Accession Q6AYD6; PDLI2_RAT
Genbank Protein ID AAS99334.1; AAH79091.1
Protein Name PDZ and LIM domain protein 2
Genbank Nucleotide ID AY531526; BC079091
Gene Name Pdlim2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000008543.5 ENSRNOT00000011663.4 ENSRNOP00000011663.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 71.47 6.00e-118 421.00 IUUC-Hsa-045868
E3 activity/Other 93.41 9.00e-163 570.00 IUUC-Mmu-063244
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity).
 Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity).
Protein Sequence
(Fasta)
MALTVNVVGP APWGFRISGG RDFHTPIIVT KVTERGKAEA ADLRPGDIIV AINGESAESM 60
LHAEAQSKIR QSASPLRLQL DRSQTASPGQ INGEGSLDML ATRFQGSLRT HHNSQSSQRS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-104992|E3,E3 activity/Other|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGACGGCTG CGGTGGAACG GCGGTGGCTC CTCGTCCTTA CTCCCTCTGT TCTTCCCTCC 60
CTCTTTCCCT TTCCTGGCGG GCCTGGCCGC CCAGCCCAAC AGGCAAGCGG CAGCCAGGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-104992|E3,E3 activity/Other|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0440--LIM domain
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
Interpro

IPR031847--DUF4749
IPR001478--PDZ
IPR001781--Znf_LIM
PROSITE

PS00478--LIM_DOMAIN_1
PS50023--LIM_DOMAIN_2
PS50106--PDZ
Pfam

PF15936--DUF4749
PF00412--LIM
PF00595--PDZ
SMART

SM00132--LIM
SM00228--PDZ
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0051393--F:alpha-actinin binding
GO:0031005--F:filamin binding
GO:0051371--F:muscle alpha-actinin binding
GO:0032036--F:myosin heavy chain binding
GO:0008270--F:zinc ion binding
KEGG rno:290354
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001484 Ailuropoda melanoleuca 74.93 1.00e-123 436.00
IUUC-Aca-004512 Anolis carolinensis 56.90 2.00e-92 332.00
IUUC-Ame-011626 Astyanax mexicanus 44.90 1.00e-75 276.00
IUUC-Bta-012510 Bos taurus 73.18 8.00e-119 419.00
IUUC-Cja-019248 Callithrix jacchus 71.07 6.00e-122 430.00
IUUC-Cfa-020352 Canis familiaris 73.03 5.00e-121 427.00
IUUC-Cpo-021995 Cavia porcellus 67.80 4.00e-109 387.00
IUUC-Csa-024190 Chlorocebus sabaeus 74.01 2.00e-118 419.00
IUUC-Dre-027418 Danio rerio 43.66 4.00e-69 254.00
IUUC-Dor-030439 Dipodomys ordii 62.07 7.00e-61 228.00
IUUC-Dme-031753 Drosophila melanogaster 37.80 1.00e-10 61.20
IUUC-Eca-034183 Equus caballus 74.72 1.00e-119 422.00
IUUC-Eeu-034958 Erinaceus europaeus 71.92 2.00e-88 318.00
IUUC-Fca-035680 Felis catus 76.12 8.00e-123 433.00
IUUC-Fal-037626 Ficedula albicollis 36.51 2.00e-07 51.60
IUUC-Gmo-038558 Gadus morhua 54.81 1.00e-39 157.00
IUUC-Gac-041738 Gasterosteus aculeatus 46.63 1.00e-81 296.00
IUUC-Ggo-044609 Gorilla gorilla 72.60 9.00e-119 419.00
IUUC-Hsa-045868 Homo sapiens 72.85 1.00e-116 413.00
IUUC-Itr-048876 Ictidomys tridecemlineatus 78.93 4.00e-124 437.00
IUUC-Loc-052212 Lepisosteus oculatus 47.51 5.00e-79 287.00
IUUC-Laf-053824 Loxodonta africana 79.14 1.00e-120 426.00
IUUC-Mcc-054962 Macaca mulatta 74.01 2.00e-118 419.00
IUUC-Meu-056007 Macropus eugenii 75.26 7.00e-41 161.00
IUUC-Mmr-060607 Microcebus murinus 76.55 3.00e-120 424.00
IUUC-Mdo-062935 Monodelphis domestica 64.38 5.00e-52 197.00
IUUC-Mmu-063244 Mus musculus 93.41 4.00e-163 567.00
IUUC-Mpu-065888 Mustela putorius furo 74.58 4.00e-110 390.00
IUUC-Mlu-067124 Myotis lucifugus 75.56 3.00e-130 457.00
IUUC-Ncr-068674 Neurospora crassa 41.07 3.00e-07 50.80
IUUC-Nle-069063 Nomascus leucogenys 72.64 3.00e-82 298.00
IUUC-Opr-071221 Ochotona princeps 72.11 7.00e-101 360.00
IUUC-Ont-072000 Oreochromis niloticus 43.75 5.00e-74 271.00
IUUC-Oan-073012 Ornithorhynchus anatinus 54.67 6.00e-82 297.00
IUUC-Ocu-074376 Oryctolagus cuniculus 73.71 1.00e-109 389.00
IUUC-Ola-086915 Oryzias latipes 43.64 4.00e-74 271.00
IUUC-Oga-088393 Otolemur garnettii 75.91 9.00e-123 433.00
IUUC-Oar-089421 Ovis aries 72.63 7.00e-121 426.00
IUUC-Ptr-091089 Pan troglodytes 73.25 2.00e-104 372.00
IUUC-Pan-092163 Papio anubis 74.01 8.00e-114 403.00
IUUC-Psi-093043 Pelodiscus sinensis 44.75 2.00e-70 259.00
IUUC-Pno-094933 Phaeosphaeria nodorum 27.78 1.00e-03 38.50
IUUC-Pfo-096885 Poecilia formosa 54.55 5.00e-40 158.00
IUUC-Pab-097988 Pongo abelii 73.25 2.00e-104 372.00
IUUC-Pca-100131 Procavia capensis 77.56 9.00e-114 404.00
IUUC-Pva-102706 Pteropus vampyrus 69.66 4.00e-116 412.00
IUUC-Ptt-104003 Puccinia triticina 34.69 3.50e-01 30.00
IUUC-Pte-104256 Pyrenophora teres 35.19 1.00e-05 45.40
IUUC-Pyt-104720 Pyrenophora triticirepentis 35.19 2.00e-05 43.10
IUUC-Sha-107463 Sarcophilus harrisii 59.49 9.00e-67 246.00
IUUC-Sar-113038 Sorex araneus 40.91 4.00e-18 86.70
IUUC-Sre-115199 Sporisorium reilianum 27.59 1.50e-01 32.30
IUUC-Ssc-115811 Sus scrofa 73.54 8.00e-119 419.00
IUUC-Tae-123985 Triticum aestivum 36.84 6.20e-02 31.60
IUUC-Tbe-127240 Tupaia belangeri 61.16 3.00e-71 261.00
IUUC-Ttr-128236 Tursiops truncatus 58.76 3.00e-87 315.00
IUUC-Uma-129653 Ustilago maydis 27.59 2.90e-01 31.20
IUUC-Vpa-130569 Vicugna pacos 49.72 2.00e-74 271.00
Created Date 25-Jun-2017

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