iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107325

Ensembl Protein ID

ENSSHAP00000016562.1

UniProt Accession

G3WMA7; G3WMA7_SARHA

Genbank Protein ID

ENSSHAP00000016562

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01175724

Gene Name

VAV3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000014087.1	ENSSHAT00000016701.1	ENSSHAP00000016562.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.30e-14	51.9	793	844

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l kGdvv++   +   +gW++g  e++g+ G fP+ +ve+
   Q: 793  IARYDFCARDMRELSLSKGDVVKIY-TKMSVNGWWRG--EANGRVGWFPSTYVEE 844
           688*********************9.888889*****..9*************86 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MEPWRQCAQW LIHCKVLPAN HRVTWDSAQV FDLAQTLRDG VLLCQLLNNL KGHSINLKEI 60
NLRPQMSQFL CLKNIRTFLA ACCETFGMRK SELFEAFDLF DVRDFGKVIE TLSRLSRTPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAGTAGCAG ACGGAAGAGA GCTAGCGAGC GAACAAGTCA CTGCAGCTGC TGCGGCTGCC 60
GCCGCCGCTG CCTCAGTGAG TCGGAGCAGA GGCGTCTGGA GCTCGGCTGC GCTCGGAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
IPR003096--SM22_calponin

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00888--SM22CALPONIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007229--P:integrin-mediated signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0030593--P:neutrophil chemotaxis
GO:0030890--P:positive regulation of B cell proliferation
GO:0045785--P:positive regulation of cell adhesion
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0042493--P:response to drug
GO:0007264--P:small GTPase mediated signal transduction
GO:0006906--P:vesicle fusion

KEGG

shr:100919264

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001362	Ailuropoda melanoleuca	93.51	0.00e+00	1556.00
IUUC-Apl-003734	Anas platyrhynchos	87.15	0.00e+00	1360.00
IUUC-Aca-004477	Anolis carolinensis	81.81	0.00e+00	1393.00
IUUC-Ame-011279	Astyanax mexicanus	66.04	0.00e+00	1115.00
IUUC-Bta-012722	Bos taurus	91.85	0.00e+00	1539.00
IUUC-Cel-018578	Caenorhabditis elegans	30.68	6.00e-72	265.00
IUUC-Cja-018941	Callithrix jacchus	93.56	0.00e+00	1545.00
IUUC-Cfa-020266	Canis familiaris	93.82	0.00e+00	1382.00
IUUC-Cpo-021966	Cavia porcellus	92.52	0.00e+00	1344.00
IUUC-Csa-023892	Chlorocebus sabaeus	92.84	0.00e+00	1421.00
IUUC-Cin-025115	Ciona intestinalis	37.13	2.00e-139	489.00
IUUC-Csv-025995	Ciona savignyi	35.54	1.00e-146	513.00
IUUC-Dre-028199	Danio rerio	66.63	0.00e+00	1115.00
IUUC-Dno-029474	Dasypus novemcinctus	93.39	0.00e+00	1561.00
IUUC-Eca-033961	Equus caballus	93.29	0.00e+00	1410.00
IUUC-Eeu-034719	Erinaceus europaeus	73.52	0.00e+00	763.00
IUUC-Fca-036572	Felis catus	93.05	0.00e+00	1515.00
IUUC-Fal-036802	Ficedula albicollis	84.44	0.00e+00	1477.00
IUUC-Gmo-039409	Gadus morhua	69.21	0.00e+00	1157.00
IUUC-Gga-040884	Gallus gallus	86.29	0.00e+00	1481.00
IUUC-Gac-041395	Gasterosteus aculeatus	70.86	0.00e+00	1233.00
IUUC-Ggo-044460	Gorilla gorilla	90.94	0.00e+00	1344.00
IUUC-Hsa-046099	Homo sapiens	90.40	0.00e+00	1544.00
IUUC-Hvu-047839	Hordeum vulgare	55.00	8.00e-08	49.70
IUUC-Itr-048144	Ictidomys tridecemlineatus	89.36	0.00e+00	1351.00
IUUC-Lch-049650	Latimeria chalumnae	82.63	3.00e-110	390.00
IUUC-Loc-052487	Lepisosteus oculatus	72.57	0.00e+00	1226.00
IUUC-Laf-054564	Loxodonta africana	93.51	0.00e+00	1556.00
IUUC-Mcc-054622	Macaca mulatta	89.94	0.00e+00	1538.00
IUUC-Meu-056680	Macropus eugenii	90.90	0.00e+00	1503.00
IUUC-Mga-060013	Meleagris gallopavo	83.37	0.00e+00	1407.00
IUUC-Mmr-061251	Microcebus murinus	88.81	0.00e+00	1561.00
IUUC-Mdo-061875	Monodelphis domestica	98.46	0.00e+00	1644.00
IUUC-Mmu-063735	Mus musculus	92.56	0.00e+00	1574.00
IUUC-Mpu-065856	Mustela putorius furo	93.39	0.00e+00	1554.00
IUUC-Mlu-068108	Myotis lucifugus	88.57	0.00e+00	1483.00
IUUC-Nle-069863	Nomascus leucogenys	89.18	0.00e+00	1509.00
IUUC-Opr-070372	Ochotona princeps	81.50	0.00e+00	1008.00
IUUC-Ont-072286	Oreochromis niloticus	71.39	0.00e+00	1219.00
IUUC-Ocu-074194	Oryctolagus cuniculus	93.51	0.00e+00	1562.00
IUUC-Ola-086336	Oryzias latipes	70.51	0.00e+00	1218.00
IUUC-Oar-089272	Ovis aries	91.85	0.00e+00	1578.00
IUUC-Ptr-090652	Pan troglodytes	90.89	0.00e+00	1547.00
IUUC-Pan-092550	Papio anubis	89.34	0.00e+00	1356.00
IUUC-Psi-093784	Pelodiscus sinensis	80.57	0.00e+00	1257.00
IUUC-Pfo-097308	Poecilia formosa	69.18	0.00e+00	1215.00
IUUC-Pab-098698	Pongo abelii	91.26	0.00e+00	1546.00
IUUC-Pva-102262	Pteropus vampyrus	92.93	0.00e+00	1496.00
IUUC-Rno-105421	Rattus norvegicus	91.62	0.00e+00	1569.00
IUUC-Sly-111123	Solanum lycopersicum	50.94	2.00e-09	56.20
IUUC-Stu-112434	Solanum tuberosum	50.94	3.00e-09	56.20
IUUC-Sar-113456	Sorex araneus	87.49	0.00e+00	1473.00
IUUC-Tgu-116595	Taeniopygia guttata	83.55	0.00e+00	1392.00
IUUC-Tru-117884	Takifugu rubripes	65.93	0.00e+00	1174.00
IUUC-Tsy-119429	Tarsius syrichta	85.62	0.00e+00	1291.00
IUUC-Tni-119951	Tetraodon nigroviridis	67.95	0.00e+00	1131.00
IUUC-Tbe-127995	Tupaia belangeri	83.25	2.00e-174	605.00
IUUC-Ttr-128281	Tursiops truncatus	92.80	0.00e+00	1548.00
IUUC-Xtr-132427	Xenopus tropicalis	72.50	0.00e+00	1281.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence