iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Yli-134403

Ensembl Protein ID

CAG82578

UniProt Accession

Q6CG48; LIS1_YARLI

Genbank Protein ID

CAG82578.1

Protein Name

Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog

Genbank Nucleotide ID

CR382128

Gene Name

PAC1; LIS1; YALI0B00902g

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YALI0_B00902g	CAG82578	CAG82578

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.90e-38	126.7	358	392
UBD/Beta-Prp	5.50e-55	185.0	187	315

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           gH ++v+++ + +  ++lvs sdD+t+++WDl +g
   Q: 358  GHDNWVRGVVLhPAgRYLVSVSDDKTMRCWDLEQG 392
           8********9995569***************9877 PP

UBD/Beta-Prp

   S: 145  vhpdg.nllvsGslDrtvrlWdlktg.kllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssD 243
           +h +   llvs+s D t+r+Wd +++   ++tltg h++ +  ++f+ +g++++s+s+d+tv++w++q+g cvrt++ghtd+vks +++ n+e++ s++ D
   Q: 187  SHAQPrALLVSCSSDLTIRIWDPQNEyANVKTLTG-HDHTISAVKFTASGNHVISASRDKTVRVWSVQSGYCVRTVHGHTDWVKSCAAL-NEEFIFSAGID 285
           34444489999999999999999776246888898.99999999999999999999999999999999999999999999999999999.99999999999 PP
   S: 244  gsiriWdlrsgdllktlqlhnssvisvavls 274
            + r+    sgd   tl +h++ +  vav +
   Q: 286  HVTRVSEFVSGDGKMTLLGHEHVIEGVAV-Y 315
           99999999999999888888877777776.4 PP

Organism

Yarrowia lipolytica

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.

Protein Sequence
(Fasta)

MESLLTDKQR SDLETSIFGY VSRLTNDEAL LSQLAAVLSQ PSGSEPVPAD TLKANALLLE 60
KKWLSVIRLQ RKVMDLETRL EAAEREASST HKANGLGAGD PKTWLPKTSR FSLLHKQPVN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGTCGC TACTGACGGA TAAACAACGC AGCGACCTGG AAACCAGCAT TTTCGGATAC 60
GTCAGCCGGC TGACTAACGA CGAGGCGCTG CTGAGTCAGC TGGCGGCGGT TCTGAGTCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005938--C:cell cortex
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0008017--F:microtubule binding
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0007097--P:nuclear migration
GO:2000574--P:regulation of microtubule motor activity
GO:0000003--P:reproduction
GO:0047496--P:vesicle transport along microtubule

KEGG

yli:YALI0B00902g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	40.81	5.00e-79	285.00
IUUC-Apl-004024	Anas platyrhynchos	39.01	9.00e-81	291.00
IUUC-Aca-004564	Anolis carolinensis	38.34	5.00e-78	282.00
IUUC-Ago-007862	Ashbya gossypii	27.35	2.00e-40	157.00
IUUC-Acl-008360	Aspergillus clavatus	42.04	1.00e-103	368.00
IUUC-Afl-008502	Aspergillus flavus	43.20	3.00e-97	346.00
IUUC-Afu-008848	Aspergillus fumigatus	42.33	4.00e-107	379.00
IUUC-Ani-009173	Aspergillus nidulans	39.32	2.00e-90	324.00
IUUC-Ang-009873	Aspergillus niger	38.33	2.00e-92	330.00
IUUC-Aor-009973	Aspergillus oryzae	40.97	3.00e-94	336.00
IUUC-Ate-010523	Aspergillus terreus	38.00	1.00e-89	321.00
IUUC-Ame-010969	Astyanax mexicanus	38.57	1.00e-79	288.00
IUUC-Bgr-011972	Blumeria graminis	42.03	1.00e-104	370.00
IUUC-Bta-013106	Bos taurus	38.34	5.00e-80	289.00
IUUC-Bci-013615	Botrytis cinerea	42.54	2.00e-101	360.00
IUUC-Cel-018459	Caenorhabditis elegans	36.90	9.00e-79	285.00
IUUC-Cja-018755	Callithrix jacchus	40.81	4.00e-79	286.00
IUUC-Cfa-020749	Canis familiaris	38.34	5.00e-80	289.00
IUUC-Cpo-022371	Cavia porcellus	38.34	5.00e-80	289.00
IUUC-Csa-023524	Chlorocebus sabaeus	38.83	6.00e-70	255.00
IUUC-Cho-024764	Choloepus hoffmanni	35.52	1.00e-65	241.00
IUUC-Cin-025753	Ciona intestinalis	36.67	6.00e-75	272.00
IUUC-Csv-025817	Ciona savignyi	37.86	2.00e-75	274.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	41.82	7.00e-95	338.00
IUUC-Cne-027087	Cryptococcus neoformans	40.93	2.00e-81	293.00
IUUC-Dre-028314	Danio rerio	38.79	1.00e-79	288.00
IUUC-Dno-029050	Dasypus novemcinctus	38.34	5.00e-80	289.00
IUUC-Dor-030222	Dipodomys ordii	34.75	2.00e-70	257.00
IUUC-Dse-031164	Dothistroma septosporum	40.99	5.00e-97	345.00
IUUC-Dme-031745	Drosophila melanogaster	39.73	6.00e-73	265.00
IUUC-Ete-032508	Echinops telfairi	38.96	6.00e-57	212.00
IUUC-Eca-034288	Equus caballus	40.81	2.00e-78	284.00
IUUC-Eeu-034984	Erinaceus europaeus	34.53	3.00e-69	253.00
IUUC-Fca-036498	Felis catus	38.34	5.00e-80	289.00
IUUC-Fal-036920	Ficedula albicollis	39.01	9.00e-81	291.00
IUUC-Fox-037996	Fusarium oxysporum	40.17	7.00e-99	352.00
IUUC-Fso-038160	Fusarium solani	38.96	8.00e-94	335.00
IUUC-Gmo-039166	Gadus morhua	39.51	2.00e-80	290.00
IUUC-Ggr-040051	Gaeumannomyces graminis	40.37	3.00e-97	346.00
IUUC-Gga-040623	Gallus gallus	39.01	9.00e-81	291.00
IUUC-Gac-041613	Gasterosteus aculeatus	39.55	3.00e-80	290.00
IUUC-Ggo-045410	Gorilla gorilla	36.59	5.00e-67	245.00
IUUC-Hsa-046358	Homo sapiens	38.57	3.00e-80	290.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	38.34	5.00e-80	289.00
IUUC-Kpa-049351	Komagataella pastoris	29.66	7.00e-42	162.00
IUUC-Lch-049936	Latimeria chalumnae	38.84	2.00e-81	294.00
IUUC-Loc-052476	Lepisosteus oculatus	41.31	2.00e-79	286.00
IUUC-Lma-053170	Leptosphaeria maculans	43.12	6.00e-105	372.00
IUUC-Laf-053713	Loxodonta africana	40.81	2.00e-79	287.00
IUUC-Mcc-054628	Macaca mulatta	38.34	8.00e-80	288.00
IUUC-Meu-055927	Macropus eugenii	32.14	2.00e-37	146.00
IUUC-Mor-056962	Magnaporthe oryzae	40.21	9.00e-99	351.00
IUUC-Mpo-057583	Magnaporthe poae	40.17	2.00e-92	330.00
IUUC-Mla-058819	Melampsora laricipopulina	36.82	2.00e-82	297.00
IUUC-Mga-059945	Meleagris gallopavo	38.79	2.00e-80	290.00
IUUC-Mvi-060403	Microbotryum violaceum	39.83	4.00e-89	319.00
IUUC-Mmr-061289	Microcebus murinus	40.81	4.00e-79	286.00
IUUC-Mdo-061912	Monodelphis domestica	37.89	8.00e-79	285.00
IUUC-Mmu-063253	Mus musculus	38.34	5.00e-80	289.00
IUUC-Mpu-066638	Mustela putorius furo	38.34	5.00e-80	289.00
IUUC-Mlu-067267	Myotis lucifugus	40.81	5.00e-79	285.00
IUUC-Nfi-068571	Neosartorya fischeri	40.98	1.00e-100	358.00
IUUC-Ncr-068895	Neurospora crassa	44.39	2.00e-101	360.00
IUUC-Nle-069087	Nomascus leucogenys	36.99	3.00e-58	216.00
IUUC-Opr-070579	Ochotona princeps	38.34	5.00e-80	289.00
IUUC-Ont-071905	Oreochromis niloticus	38.88	3.00e-81	293.00
IUUC-Oan-073072	Ornithorhynchus anatinus	38.34	5.00e-80	289.00
IUUC-Ocu-074180	Oryctolagus cuniculus	38.34	5.00e-80	289.00
IUUC-Ola-086815	Oryzias latipes	39.51	2.00e-81	294.00
IUUC-Oga-088219	Otolemur garnettii	40.81	3.00e-79	286.00
IUUC-Oar-090394	Ovis aries	38.34	5.00e-80	289.00
IUUC-Ptr-091517	Pan troglodytes	38.34	5.00e-80	289.00
IUUC-Pan-092421	Papio anubis	38.34	8.00e-80	288.00
IUUC-Psi-093370	Pelodiscus sinensis	38.57	4.00e-80	289.00
IUUC-Pma-094319	Petromyzon marinus	38.73	4.00e-69	253.00
IUUC-Pno-094815	Phaeosphaeria nodorum	43.18	1.00e-105	374.00
IUUC-Pfo-097089	Poecilia formosa	39.10	7.00e-81	291.00
IUUC-Pab-098421	Pongo abelii	38.34	5.00e-80	289.00
IUUC-Pca-100120	Procavia capensis	31.43	4.00e-34	136.00
IUUC-Pva-102960	Pteropus vampyrus	38.34	2.00e-80	290.00
IUUC-Pgr-103538	Puccinia graminis	36.48	1.00e-84	304.00
IUUC-Ptt-103990	Puccinia triticina	36.47	9.00e-32	129.00
IUUC-Pte-104261	Pyrenophora teres	42.24	2.00e-104	370.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	42.44	6.00e-105	372.00
IUUC-Rno-105123	Rattus norvegicus	38.34	5.00e-80	289.00
IUUC-Sce-106208	Saccharomyces cerevisiae	26.60	1.00e-41	161.00
IUUC-Sha-107010	Sarcophilus harrisii	38.12	4.00e-79	286.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	31.60	2.00e-57	214.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	45.10	1.00e-101	360.00
IUUC-Sar-113309	Sorex araneus	40.30	1.00e-77	281.00
IUUC-Sre-115003	Sporisorium reilianum	38.68	4.00e-90	322.00
IUUC-Ssc-116148	Sus scrofa	38.34	5.00e-80	289.00
IUUC-Tgu-117299	Taeniopygia guttata	38.79	1.00e-80	291.00
IUUC-Tru-118179	Takifugu rubripes	39.29	8.00e-81	291.00
IUUC-Tsy-119493	Tarsius syrichta	37.75	7.00e-78	281.00
IUUC-Tni-120355	Tetraodon nigroviridis	39.15	1.00e-78	284.00
IUUC-Tre-121977	Trichoderma reesei	38.20	3.00e-92	330.00
IUUC-Tvi-122661	Trichoderma virens	40.36	5.00e-93	332.00
IUUC-Tme-127031	Tuber melanosporum	43.19	1.00e-101	361.00
IUUC-Tbe-127492	Tupaia belangeri	33.21	5.00e-35	139.00
IUUC-Ttr-128929	Tursiops truncatus	37.89	7.00e-81	292.00
IUUC-Uma-129347	Ustilago maydis	39.02	2.00e-89	320.00
IUUC-Vda-129837	Verticillium dahliae	39.71	1.00e-95	341.00
IUUC-Vpa-130532	Vicugna pacos	31.97	5.00e-54	202.00
IUUC-Xtr-131985	Xenopus tropicalis	38.12	8.00e-80	288.00
IUUC-Xma-133314	Xiphophorus maculatus	39.15	2.00e-80	290.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence