iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-097734

Ensembl Protein ID

ENSPPYP00000008334.2

UniProt Accession

Q5R5B0; HERP1_PONAB

Genbank Protein ID

CAH91109.1; CAH93056.1

Protein Name

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

Genbank Nucleotide ID

CR858911; CR860953

Gene Name

HERPUD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000007377.2	ENSPPYT00000008674.2	ENSPPYP00000008334.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	4.90e-06	26.4	12	85

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 3    vtvksldgseltlkv..npsdtVaeLKekiekk.lgip.peqqrLiykGkiLeddktLady..glkdgstihll 70
           + vks++ ++ +l++  ++ ++V+ LK ++++     p pe+qrLiy+Gk+L d++ L d+  +   + ++hl+
   Q: 12   LLVKSPNQRHRDLELsgDRGWSVGHLKAHLSRVyPERPrPEDQRLIYSGKLLLDHQCLRDLlpKQEKRHVLHLV 85
           566666666666664347888*********999966666*********************98888888888887 PP

Organism

Pongo abelii

Functional Description
(View)

Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway.

Protein Sequence
(Fasta)

MESETEPEPV TLLVKSPNQR HRDLELSGDR GWSVGHLKAH LSRVYPERPR PEDQRLIYSG 60
KLLLDHQCLR DLLPKQEKRH VLHLVCNVKS PSKMPEINAK VAESTEEPAG SNRGQYPEDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCGCAGAGG CAGGCGCGGG GCTCCTATAA AAACCGACCG AAGCGGGGGC GCGCGCCCCA 60
GAGACGTGAA CGGTCGTTGC GGAGGTTGCG GGCGGCTGAG ACGCCGCCTG CCTGGCACCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0834--Unfolded protein response

Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

SMART

SM00213--UBQ

Gene Ontology

GO:0034704--C:calcium channel complex
GO:0005789--C:endoplasmic reticulum membrane
GO:1990037--C:Lewy body core
GO:0032469--P:endoplasmic reticulum calcium ion homeostasis
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:1902236--P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903071--P:positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0032092--P:positive regulation of protein binding
GO:0031396--P:regulation of protein ubiquitination
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

pon:100172567

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001647	Ailuropoda melanoleuca	90.03	4.00e-160	557.00
IUUC-Atr-002574	Amborella trichopoda	30.16	2.70e-01	27.70
IUUC-Apl-004142	Anas platyrhynchos	54.73	6.00e-80	290.00
IUUC-Acl-008367	Aspergillus clavatus	32.46	9.00e-06	45.40
IUUC-Afl-008623	Aspergillus flavus	41.07	1.00e-03	38.10
IUUC-Ani-009402	Aspergillus nidulans	33.70	7.00e-05	42.40
IUUC-Aor-010022	Aspergillus oryzae	41.07	2.00e-03	37.70
IUUC-Ate-010527	Aspergillus terreus	43.94	1.00e-05	45.10
IUUC-Ame-011187	Astyanax mexicanus	33.41	3.00e-50	192.00
IUUC-Bta-013339	Bos taurus	89.18	2.00e-154	538.00
IUUC-Cja-018806	Callithrix jacchus	94.39	6.00e-161	560.00
IUUC-Cfa-020141	Canis familiaris	90.55	2.00e-145	508.00
IUUC-Cpo-021802	Cavia porcellus	87.21	2.00e-163	568.00
IUUC-Csa-023973	Chlorocebus sabaeus	96.68	2.00e-177	614.00
IUUC-Cho-024463	Choloepus hoffmanni	84.03	9.00e-149	519.00
IUUC-Cin-025601	Ciona intestinalis	34.39	3.00e-14	72.40
IUUC-Csv-025997	Ciona savignyi	37.50	5.00e-10	56.20
IUUC-Cme-027117	Cyanidioschyzon merolae	38.24	2.00e-06	47.00
IUUC-Dno-029118	Dasypus novemcinctus	85.45	6.00e-170	590.00
IUUC-Dor-030815	Dipodomys ordii	84.55	2.00e-155	541.00
IUUC-Ete-033054	Echinops telfairi	69.74	2.00e-105	375.00
IUUC-Eca-033245	Equus caballus	87.97	3.00e-156	544.00
IUUC-Eeu-034795	Erinaceus europaeus	89.80	8.00e-165	572.00
IUUC-Fca-036200	Felis catus	91.34	1.00e-162	565.00
IUUC-Fal-036890	Ficedula albicollis	51.03	9.00e-77	280.00
IUUC-Fox-037920	Fusarium oxysporum	48.00	5.60e-01	28.10
IUUC-Gmo-038670	Gadus morhua	45.71	6.00e-38	151.00
IUUC-Gga-040151	Gallus gallus	53.91	1.00e-70	259.00
IUUC-Gac-041925	Gasterosteus aculeatus	37.47	4.00e-54	205.00
IUUC-Ggo-045103	Gorilla gorilla	98.11	2.00e-167	581.00
IUUC-Hsa-046226	Homo sapiens	98.98	0.00e+00	632.00
IUUC-Itr-048589	Ictidomys tridecemlineatus	91.10	4.00e-168	583.00
IUUC-Lch-050254	Latimeria chalumnae	49.36	2.00e-61	229.00
IUUC-Loc-052154	Lepisosteus oculatus	46.29	5.00e-62	231.00
IUUC-Laf-053533	Loxodonta africana	88.13	9.00e-170	589.00
IUUC-Mcc-055840	Macaca mulatta	97.44	2.00e-179	621.00
IUUC-Meu-056691	Macropus eugenii	80.13	3.00e-113	400.00
IUUC-Mga-060042	Meleagris gallopavo	53.64	1.00e-77	283.00
IUUC-Mmr-060875	Microcebus murinus	93.46	2.00e-180	625.00
IUUC-Mdo-062924	Monodelphis domestica	76.50	3.00e-127	447.00
IUUC-Mmu-063831	Mus musculus	88.24	8.00e-166	576.00
IUUC-Mpu-066883	Mustela putorius furo	90.03	6.00e-159	553.00
IUUC-Mlu-067932	Myotis lucifugus	83.24	4.00e-139	487.00
IUUC-Nfi-068353	Neosartorya fischeri	38.20	4.00e-06	46.20
IUUC-Nle-069005	Nomascus leucogenys	97.95	1.00e-180	625.00
IUUC-Opr-070231	Ochotona princeps	88.48	4.00e-163	567.00
IUUC-Ont-072578	Oreochromis niloticus	39.86	3.00e-46	179.00
IUUC-Oan-073354	Ornithorhynchus anatinus	70.31	2.00e-121	429.00
IUUC-Ocu-074495	Oryctolagus cuniculus	90.84	3.00e-163	568.00
IUUC-Ola-087167	Oryzias latipes	36.27	4.00e-60	225.00
IUUC-Oga-088825	Otolemur garnettii	92.58	6.00e-167	580.00
IUUC-Oar-089616	Ovis aries	88.48	1.00e-150	525.00
IUUC-Ptr-090458	Pan troglodytes	98.72	1.00e-180	625.00
IUUC-Pan-091940	Papio anubis	96.69	2.00e-177	614.00
IUUC-Psi-093972	Pelodiscus sinensis	56.48	2.00e-57	215.00
IUUC-Pfo-096041	Poecilia formosa	43.40	2.00e-48	186.00
IUUC-Pca-100301	Procavia capensis	79.68	2.00e-87	315.00
IUUC-Pva-102349	Pteropus vampyrus	90.41	1.00e-171	595.00
IUUC-Rno-105129	Rattus norvegicus	86.70	2.00e-162	565.00
IUUC-Sha-107280	Sarcophilus harrisii	77.38	4.00e-147	514.00
IUUC-Sar-113496	Sorex araneus	81.12	4.00e-146	510.00
IUUC-Ssc-115558	Sus scrofa	92.72	5.00e-95	339.00
IUUC-Tgu-117337	Taeniopygia guttata	49.87	8.00e-84	303.00
IUUC-Tru-118741	Takifugu rubripes	37.65	6.00e-54	204.00
IUUC-Tsy-119527	Tarsius syrichta	93.81	4.00e-132	463.00
IUUC-Tni-119885	Tetraodon nigroviridis	37.59	1.00e-52	199.00
IUUC-Tre-121967	Trichoderma reesei	35.59	1.90e-02	34.70
IUUC-Tvi-122662	Trichoderma virens	35.38	9.00e-03	35.80
IUUC-Tae-123106	Triticum aestivum	29.35	3.90e-01	28.50
IUUC-Tbe-127599	Tupaia belangeri	86.14	5.00e-85	307.00
IUUC-Ttr-128320	Tursiops truncatus	82.64	1.00e-135	475.00
IUUC-Vpa-130608	Vicugna pacos	91.00	4.00e-164	570.00
IUUC-Xtr-131896	Xenopus tropicalis	46.63	4.00e-56	211.00
IUUC-Xma-133006	Xiphophorus maculatus	40.81	8.00e-69	254.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence