iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pma-094113

UUCD1 version

UUC-PeM-00428

Ensembl Protein ID

ENSPMAP00000001823.1

UniProt Accession

S4R9E2; S4R9E2_PETMA

Protein Name

Uncharacterized protein

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPMAG00000001626.1	ENSPMAT00000001833.1	ENSPMAP00000001823.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-97	326.7	504	827

Active Site

Position(s)	Description	Evidence
796	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           d+kk l+v f gE+++d+gGv +ef+ l++k+l +p++glf+y e+++  ++ +++      e  +lF+++G ++g+a++++ ++dl++
   Q: 504  DFKKPLKVIFYGEDAVDAGGVRKEFFLLIMKDLLDPKYGLFKYYEESRLIWFSQQTF-----EDSNLFNLIGLICGLAIYNSTIVDLNF 587
           8999**********************************************9977766.....689************************ PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
           + ++yk+ll+++ +ledl+e++p++ +sl++++++ ++d+ee+ ++l+f+v  e++g ++++eL+pgG+++ V+n+N++++v+++v+y+
   Q: 588  PLALYKKLLKVEPTLEDLKELMPDVGRSLQQLLDYPDDDVEET-FCLNFTVAFENFGAMEVKELVPGGSDMVVNNANRQDFVNAYVDYI 675
           ***********************************99999997.********************************************* PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           +++++++ +eaf+ Gf++v+  ++l+lF+++el  ++ G++++d+ +l+k+t+ykg+y + +p+i+ Fwev++e++ e +k+fL F+Tg
   Q: 676  FNKSVQQLFEAFHTGFHKVCGGKVLQLFQPSELMAMVIGNTDYDWAELEKNTEYKGEYWAGHPTIKSFWEVFHELDLELKKKFLLFLTG 764
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           s+r+P+ G+++lk   +vi+   + ++ lP ++TCfn+L+LP++s k +l+ekLl  i++ +gF+l
   Q: 765  SDRIPILGMKSLK---IVIQPtGGGEQFLPVAHTCFNLLDLPKFSGKAQLREKLLQSITHYQGFSL 827
           *************...7888868888**************************************97 PP

Organism

Petromyzon marinus

Protein Sequence
(Fasta)

DKCYPALLKS LRTQKVVYIC CGEDHTAILT KEGGVFTFGA GGYGQLGHNS TNHEVNPRKV 60
FELMGSIVTQ IACGRQHTLA FVPSSGRIYS FGLGGNGQLG TGSTSNRKSP FTVQGAWVPH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATAAGTGCT ACCCTGCTCT ACTGAAGTCT CTCCGCACAC AGAAAGTTGT TTATATCTGC 60
TGTGGAGAGG ACCATACCGC TATTCTTACT AAGGTATGCT AAGCGTATAT AGCCCAGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	71.89	0.00e+00	1153.00
IUUC-Apl-003295	Anas platyrhynchos	70.96	0.00e+00	1177.00
IUUC-Aca-004336	Anolis carolinensis	68.51	0.00e+00	1137.00
IUUC-Ago-007908	Ashbya gossypii	32.72	2.00e-72	265.00
IUUC-Ame-010768	Astyanax mexicanus	65.87	0.00e+00	1109.00
IUUC-Bta-013279	Bos taurus	71.89	0.00e+00	1152.00
IUUC-Cel-018150	Caenorhabditis elegans	34.98	1.00e-122	433.00
IUUC-Cja-019023	Callithrix jacchus	71.53	0.00e+00	1147.00
IUUC-Cfa-021074	Canis familiaris	72.01	0.00e+00	1155.00
IUUC-Cpo-021461	Cavia porcellus	71.48	0.00e+00	1145.00
IUUC-Csa-024261	Chlorocebus sabaeus	71.65	0.00e+00	1148.00
IUUC-Cho-024513	Choloepus hoffmanni	53.08	0.00e+00	763.00
IUUC-Cin-025232	Ciona intestinalis	43.33	0.00e+00	678.00
IUUC-Dre-028829	Danio rerio	66.47	0.00e+00	1048.00
IUUC-Dno-029445	Dasypus novemcinctus	68.90	0.00e+00	1130.00
IUUC-Dor-030158	Dipodomys ordii	74.55	0.00e+00	689.00
IUUC-Dme-032103	Drosophila melanogaster	45.71	0.00e+00	687.00
IUUC-Ete-033072	Echinops telfairi	64.13	0.00e+00	977.00
IUUC-Eca-033317	Equus caballus	70.93	0.00e+00	1138.00
IUUC-Eeu-035098	Erinaceus europaeus	48.61	0.00e+00	731.00
IUUC-Fca-035682	Felis catus	71.65	0.00e+00	1141.00
IUUC-Fal-036969	Ficedula albicollis	70.81	0.00e+00	1178.00
IUUC-Gmo-038671	Gadus morhua	65.71	0.00e+00	1086.00
IUUC-Ggr-040110	Gaeumannomyces graminis	37.26	2.00e-77	283.00
IUUC-Gga-041174	Gallus gallus	70.81	0.00e+00	1179.00
IUUC-Gac-042600	Gasterosteus aculeatus	65.83	0.00e+00	1054.00
IUUC-Ggo-044589	Gorilla gorilla	71.29	0.00e+00	1144.00
IUUC-Hsa-046772	Homo sapiens	71.41	0.00e+00	1146.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	55.88	0.00e+00	881.00
IUUC-Kpa-049152	Komagataella pastoris	33.53	4.00e-70	258.00
IUUC-Lch-050147	Latimeria chalumnae	68.07	0.00e+00	865.00
IUUC-Loc-052684	Lepisosteus oculatus	68.03	0.00e+00	1113.00
IUUC-Laf-053844	Loxodonta africana	71.05	0.00e+00	1143.00
IUUC-Mcc-055531	Macaca mulatta	71.53	0.00e+00	1147.00
IUUC-Meu-056274	Macropus eugenii	58.72	2.00e-101	362.00
IUUC-Mga-060151	Meleagris gallopavo	67.92	0.00e+00	889.00
IUUC-Mmr-060954	Microcebus murinus	71.65	0.00e+00	1149.00
IUUC-Mdo-062246	Monodelphis domestica	70.33	0.00e+00	1124.00
IUUC-Mmu-063369	Mus musculus	70.93	0.00e+00	1166.00
IUUC-Mpu-065936	Mustela putorius furo	71.89	0.00e+00	1154.00
IUUC-Mlu-067326	Myotis lucifugus	72.14	0.00e+00	1132.00
IUUC-Nle-069453	Nomascus leucogenys	71.17	0.00e+00	1134.00
IUUC-Opr-070891	Ochotona princeps	50.54	0.00e+00	757.00
IUUC-Ont-071720	Oreochromis niloticus	67.35	0.00e+00	1077.00
IUUC-Oan-073464	Ornithorhynchus anatinus	70.08	0.00e+00	1125.00
IUUC-Ocu-074207	Oryctolagus cuniculus	71.77	0.00e+00	1156.00
IUUC-Ola-086762	Oryzias latipes	67.11	0.00e+00	1053.00
IUUC-Oga-088435	Otolemur garnettii	71.53	0.00e+00	1147.00
IUUC-Oar-089233	Ovis aries	71.89	0.00e+00	1151.00
IUUC-Ptr-091368	Pan troglodytes	71.53	0.00e+00	1147.00
IUUC-Pan-092300	Papio anubis	71.65	0.00e+00	1148.00
IUUC-Psi-093406	Pelodiscus sinensis	70.84	0.00e+00	1171.00
IUUC-Pfo-097021	Poecilia formosa	66.79	0.00e+00	1128.00
IUUC-Pab-098327	Pongo abelii	71.65	0.00e+00	1150.00
IUUC-Pca-101075	Procavia capensis	62.35	5.00e-156	543.00
IUUC-Pva-102909	Pteropus vampyrus	57.35	0.00e+00	919.00
IUUC-Pte-104055	Pyrenophora teres	30.16	2.00e-46	179.00
IUUC-Rno-105457	Rattus norvegicus	71.53	0.00e+00	1183.00
IUUC-Sha-106632	Sarcophilus harrisii	70.08	0.00e+00	1124.00
IUUC-Spo-108271	Schizosaccharomyces pombe	32.60	1.00e-74	273.00
IUUC-Sar-113679	Sorex araneus	63.30	0.00e+00	633.00
IUUC-Ssc-115473	Sus scrofa	56.06	0.00e+00	882.00
IUUC-Tgu-116849	Taeniopygia guttata	66.43	0.00e+00	1076.00
IUUC-Tru-118206	Takifugu rubripes	65.07	0.00e+00	994.00
IUUC-Tsy-119521	Tarsius syrichta	58.34	0.00e+00	838.00
IUUC-Tni-120233	Tetraodon nigroviridis	63.42	0.00e+00	1000.00
IUUC-Tbe-127941	Tupaia belangeri	53.02	0.00e+00	843.00
IUUC-Ttr-129172	Tursiops truncatus	55.58	0.00e+00	870.00
IUUC-Vpa-130448	Vicugna pacos	71.41	0.00e+00	1143.00
IUUC-Xtr-132719	Xenopus tropicalis	58.96	0.00e+00	953.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence