iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020807

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase Mdm2

Genbank Nucleotide ID

AAEX03007044

Gene Name

MDM2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000000418.3	ENSCAFT00000000663.3	ENSCAFP00000000608.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	92.65	0.00e+00	757.00	IUUC-Hsa-046376
E3 activity/RING/RING	78.63	1.00e-176	616.00	IUUC-Mmu-063207
E3 activity/RING/RING	80.88	0.00e+00	639.00	IUUC-Rno-105641

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Canis familiaris

Protein Sequence
(Fasta)

MCNTNMSVST DGAVSTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVIFYLGQY 60
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQHEPSDSGT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAAATGTGC AATACCAACA TGTCTGTGTC TACTGATGGT GCTGTAAGCA CCTCACAGAT 60
TCCAGCTTCG GAGCAGGAGA CCCTGGTTGG TATTTATGGG GGTGACCAAC TGACTTCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0043234--C:protein complex
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0003283--P:atrial septum development
GO:0003181--P:atrioventricular valve morphogenesis
GO:0001568--P:blood vessel development
GO:0001974--P:blood vessel remodeling
GO:0060411--P:cardiac septum morphogenesis
GO:0071456--P:cellular response to hypoxia
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0003203--P:endocardial cushion morphogenesis
GO:0045184--P:establishment of protein localization
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0018205--P:peptidyl-lysine modification
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0031648--P:protein destabilization
GO:0034504--P:protein localization to nucleus
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0002027--P:regulation of heart rate
GO:0046677--P:response to antibiotic
GO:0007089--P:traversing start control point of mitotic cell cycle
GO:0003281--P:ventricular septum development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002039	Ailuropoda melanoleuca	96.41	0.00e+00	835.00
IUUC-Apl-003193	Anas platyrhynchos	63.29	2.00e-147	515.00
IUUC-Aca-004305	Anolis carolinensis	58.55	6.00e-120	424.00
IUUC-Ame-010675	Astyanax mexicanus	43.06	2.00e-75	276.00
IUUC-Bta-013270	Bos taurus	92.03	0.00e+00	756.00
IUUC-Cja-019744	Callithrix jacchus	89.96	0.00e+00	745.00
IUUC-Cpo-022182	Cavia porcellus	86.97	0.00e+00	702.00
IUUC-Csa-023541	Chlorocebus sabaeus	92.23	0.00e+00	753.00
IUUC-Cho-024831	Choloepus hoffmanni	75.37	6.00e-88	317.00
IUUC-Csv-026151	Ciona savignyi	31.17	3.00e-11	62.00
IUUC-Dre-028419	Danio rerio	40.39	2.00e-43	169.00
IUUC-Dno-028950	Dasypus novemcinctus	92.02	0.00e+00	767.00
IUUC-Dor-031048	Dipodomys ordii	70.08	3.00e-159	555.00
IUUC-Ete-032264	Echinops telfairi	67.43	2.00e-159	555.00
IUUC-Eca-033301	Equus caballus	82.35	0.00e+00	694.00
IUUC-Eeu-035005	Erinaceus europaeus	81.14	0.00e+00	634.00
IUUC-Fca-035454	Felis catus	95.38	0.00e+00	801.00
IUUC-Fal-036720	Ficedula albicollis	61.13	2.00e-73	269.00
IUUC-Gmo-039296	Gadus morhua	39.17	2.00e-38	152.00
IUUC-Gga-040251	Gallus gallus	63.71	6.00e-142	497.00
IUUC-Ggo-044948	Gorilla gorilla	84.45	0.00e+00	683.00
IUUC-Hsa-046376	Homo sapiens	92.65	0.00e+00	758.00
IUUC-Itr-048328	Ictidomys tridecemlineatus	89.75	0.00e+00	719.00
IUUC-Lch-050037	Latimeria chalumnae	55.67	1.00e-109	390.00
IUUC-Loc-051837	Lepisosteus oculatus	49.69	4.00e-104	371.00
IUUC-Laf-053483	Loxodonta africana	83.89	0.00e+00	693.00
IUUC-Mcc-055294	Macaca mulatta	92.44	0.00e+00	756.00
IUUC-Mga-060007	Meleagris gallopavo	63.53	1.00e-137	483.00
IUUC-Mmr-060673	Microcebus murinus	92.23	0.00e+00	783.00
IUUC-Mdo-063057	Monodelphis domestica	73.89	0.00e+00	627.00
IUUC-Mmu-063207	Mus musculus	78.63	2.00e-170	592.00
IUUC-Mpu-065836	Mustela putorius furo	95.34	0.00e+00	826.00
IUUC-Mlu-068193	Myotis lucifugus	88.73	0.00e+00	749.00
IUUC-Nle-069927	Nomascus leucogenys	92.23	0.00e+00	755.00
IUUC-Opr-070590	Ochotona princeps	83.82	0.00e+00	672.00
IUUC-Ont-071984	Oreochromis niloticus	41.28	3.00e-44	172.00
IUUC-Oan-072744	Ornithorhynchus anatinus	71.46	9.00e-157	546.00
IUUC-Ocu-074071	Oryctolagus cuniculus	91.21	0.00e+00	751.00
IUUC-Ola-087329	Oryzias latipes	38.63	3.00e-42	166.00
IUUC-Oga-088135	Otolemur garnettii	82.71	0.00e+00	703.00
IUUC-Oar-090078	Ovis aries	91.60	0.00e+00	786.00
IUUC-Ptr-091399	Pan troglodytes	92.65	0.00e+00	759.00
IUUC-Pan-092720	Papio anubis	92.44	0.00e+00	756.00
IUUC-Psi-093591	Pelodiscus sinensis	64.24	1.00e-120	426.00
IUUC-Pfo-096316	Poecilia formosa	40.21	1.00e-65	243.00
IUUC-Pab-097696	Pongo abelii	91.81	0.00e+00	746.00
IUUC-Pca-100974	Procavia capensis	81.17	0.00e+00	713.00
IUUC-Pva-102488	Pteropus vampyrus	87.21	0.00e+00	678.00
IUUC-Rno-105641	Rattus norvegicus	80.88	0.00e+00	633.00
IUUC-Sha-107314	Sarcophilus harrisii	72.06	0.00e+00	651.00
IUUC-Sar-112938	Sorex araneus	84.45	0.00e+00	723.00
IUUC-Ssc-115495	Sus scrofa	92.86	0.00e+00	751.00
IUUC-Tgu-116623	Taeniopygia guttata	62.90	3.00e-140	491.00
IUUC-Tru-117820	Takifugu rubripes	38.59	1.00e-63	237.00
IUUC-Tsy-119162	Tarsius syrichta	65.56	8.00e-83	300.00
IUUC-Tbe-127816	Tupaia belangeri	87.74	2.00e-107	382.00
IUUC-Ttr-129194	Tursiops truncatus	80.18	5.00e-176	610.00
IUUC-Vpa-130326	Vicugna pacos	87.39	0.00e+00	709.00
IUUC-Xtr-132216	Xenopus tropicalis	54.16	1.00e-108	387.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence