iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044948

UUCD1 version

UUC-GoG-00495

Ensembl Protein ID

ENSGGOP00000012595.2

UniProt Accession

G3RAW3; G3RAW3_GORGO

Protein Name

Uncharacterized protein

Gene Name

MDM2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000012907.2	ENSGGOT00000012958.2	ENSGGOP00000012595.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	90.43	0.00e+00	772.00	IUUC-Hsa-046376
E3 activity/RING/RING	74.19	9.00e-176	613.00	IUUC-Mmu-063207
E3 activity/RING/RING	76.33	0.00e+00	630.00	IUUC-Rno-105641

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVLFYLGQY 60
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQQGKINLRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGAAAACCC CGGATGGTGA GGAGCAGGTA CCGGCCCGGC AGCGAGCGGT CACTTTTGGG 60
TCTGGGCTCT GACGGTGTCC CCTCTATCGC TGGTTCCCAG CCTCTGCCCG TTCGCAGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0043234--C:protein complex
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0003283--P:atrial septum development
GO:0003181--P:atrioventricular valve morphogenesis
GO:0001568--P:blood vessel development
GO:0001974--P:blood vessel remodeling
GO:0060411--P:cardiac septum morphogenesis
GO:0071456--P:cellular response to hypoxia
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0003203--P:endocardial cushion morphogenesis
GO:0045184--P:establishment of protein localization
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0018205--P:peptidyl-lysine modification
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0031648--P:protein destabilization
GO:0034504--P:protein localization to nucleus
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0002027--P:regulation of heart rate
GO:0046677--P:response to antibiotic
GO:0007089--P:traversing start control point of mitotic cell cycle
GO:0003281--P:ventricular septum development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002039	Ailuropoda melanoleuca	86.56	0.00e+00	770.00
IUUC-Apl-003193	Anas platyrhynchos	62.32	2.00e-154	538.00
IUUC-Aca-004305	Anolis carolinensis	56.59	2.00e-116	412.00
IUUC-Ame-010675	Astyanax mexicanus	46.40	9.00e-54	204.00
IUUC-Bta-013270	Bos taurus	86.18	0.00e+00	742.00
IUUC-Cja-019744	Callithrix jacchus	88.24	0.00e+00	790.00
IUUC-Cfa-020807	Canis familiaris	84.45	0.00e+00	711.00
IUUC-Cpo-022182	Cavia porcellus	82.24	0.00e+00	702.00
IUUC-Cre-022828	Chlamydomonas reinhardtii	35.42	6.00e-06	42.00
IUUC-Csa-023541	Chlorocebus sabaeus	90.02	0.00e+00	778.00
IUUC-Cho-024831	Choloepus hoffmanni	75.37	3.00e-87	314.00
IUUC-Csv-026151	Ciona savignyi	31.75	1.00e-09	56.60
IUUC-Dre-028419	Danio rerio	43.17	1.00e-50	194.00
IUUC-Dno-028950	Dasypus novemcinctus	85.13	0.00e+00	749.00
IUUC-Dor-031048	Dipodomys ordii	77.78	2.00e-106	379.00
IUUC-Ete-032264	Echinops telfairi	64.10	5.00e-158	550.00
IUUC-Eca-033301	Equus caballus	75.97	0.00e+00	672.00
IUUC-Eeu-035005	Erinaceus europaeus	73.32	6.00e-173	600.00
IUUC-Fca-035454	Felis catus	86.35	0.00e+00	762.00
IUUC-Fal-036720	Ficedula albicollis	58.47	1.00e-70	259.00
IUUC-Gmo-039296	Gadus morhua	41.42	4.00e-45	174.00
IUUC-Gga-040251	Gallus gallus	64.02	1.00e-152	532.00
IUUC-Gac-041528	Gasterosteus aculeatus	38.57	2.00e-34	140.00
IUUC-Hsa-046376	Homo sapiens	90.43	0.00e+00	783.00
IUUC-Itr-048328	Ictidomys tridecemlineatus	84.96	0.00e+00	715.00
IUUC-Lch-050037	Latimeria chalumnae	54.99	1.00e-112	399.00
IUUC-Loc-051837	Lepisosteus oculatus	50.00	4.00e-113	401.00
IUUC-Laf-053483	Loxodonta africana	80.00	0.00e+00	686.00
IUUC-Mcc-055294	Macaca mulatta	90.22	0.00e+00	782.00
IUUC-Mga-060007	Meleagris gallopavo	63.88	4.00e-145	507.00
IUUC-Mmr-060673	Microcebus murinus	86.35	0.00e+00	770.00
IUUC-Mdo-063057	Monodelphis domestica	69.43	0.00e+00	641.00
IUUC-Mmu-063207	Mus musculus	74.19	2.00e-173	602.00
IUUC-Mpu-065836	Mustela putorius furo	84.73	0.00e+00	768.00
IUUC-Mlu-068193	Myotis lucifugus	80.73	0.00e+00	721.00
IUUC-Nle-069927	Nomascus leucogenys	90.43	0.00e+00	783.00
IUUC-Opr-070590	Ochotona princeps	78.98	0.00e+00	667.00
IUUC-Ont-071984	Oreochromis niloticus	41.80	1.00e-50	194.00
IUUC-Oan-072744	Ornithorhynchus anatinus	67.42	4.00e-155	540.00
IUUC-Ocu-074071	Oryctolagus cuniculus	85.37	0.00e+00	736.00
IUUC-Ola-087329	Oryzias latipes	38.08	6.00e-71	261.00
IUUC-Oga-088135	Otolemur garnettii	76.97	0.00e+00	691.00
IUUC-Oar-090078	Ovis aries	85.74	0.00e+00	773.00
IUUC-Ptr-091399	Pan troglodytes	90.84	0.00e+00	787.00
IUUC-Pan-092720	Papio anubis	90.22	0.00e+00	782.00
IUUC-Psi-093591	Pelodiscus sinensis	63.70	1.00e-125	443.00
IUUC-Pfo-096316	Poecilia formosa	45.49	2.00e-49	190.00
IUUC-Pab-097696	Pongo abelii	90.22	0.00e+00	776.00
IUUC-Pca-100974	Procavia capensis	78.34	0.00e+00	711.00
IUUC-Pva-102488	Pteropus vampyrus	80.45	0.00e+00	655.00
IUUC-Rno-105641	Rattus norvegicus	75.46	1.00e-180	625.00
IUUC-Sha-107314	Sarcophilus harrisii	70.45	0.00e+00	659.00
IUUC-Sar-112938	Sorex araneus	79.39	0.00e+00	726.00
IUUC-Ssc-115495	Sus scrofa	85.54	0.00e+00	726.00
IUUC-Tgu-116623	Taeniopygia guttata	63.36	1.00e-148	519.00
IUUC-Tru-117820	Takifugu rubripes	39.58	3.00e-47	182.00
IUUC-Tsy-119162	Tarsius syrichta	63.56	1.00e-77	283.00
IUUC-Tni-119793	Tetraodon nigroviridis	43.53	2.00e-45	176.00
IUUC-Tbe-127816	Tupaia belangeri	91.63	4.00e-123	434.00
IUUC-Ttr-129194	Tursiops truncatus	74.45	2.00e-173	601.00
IUUC-Vpa-130326	Vicugna pacos	80.04	0.00e+00	676.00
IUUC-Xtr-132216	Xenopus tropicalis	54.49	1.00e-115	409.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence