iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-063057

UUCD1 version

UUC-MoD-00367

Ensembl Protein ID

ENSMODP00000008947.3

UniProt Accession

F6WSI6; F6WSI6_MONDO

Protein Name

Uncharacterized protein

Gene Name

MDM2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000007219.3	ENSMODT00000009124.3	ENSMODP00000008947.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.10e-08	34.2	431	472

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplv.lpCgHvf.hadClqkwpglknssskefrCPlCr 46
           C iC++++k+g +v ++ gH++ +++C +k+      ++++  CP+Cr
   Q: 431  CVICQSRPKNGCIVhGRTGHLMaCFTCAKKL------KKRNKPCPVCR 472
           ********9984443889**888*****999......**********8 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MCNTKMSSDT DGALSTSQMP ASEQEALVRP KPLLLKLLKF AGAQKDTFTM KEVLFYLGQY 60
IMSKQLYDKK QQHIVYCSDD LLGDLFGVPS FSVKEHRRLY AMISRNLIAV NQQQEPAFPN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTAAACGTT GGGGGAGGGG AATACCCGGA GAAGCTCCGG GAGGTTTCCG GCGCCGACGC 60
GTTGGGGGCT TCCCTGGGGT GCGCGGATAC CACTGAGGCC CTTACCCGAC CCCCCCCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0043234--C:protein complex
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0003283--P:atrial septum development
GO:0003181--P:atrioventricular valve morphogenesis
GO:0001568--P:blood vessel development
GO:0001974--P:blood vessel remodeling
GO:0060411--P:cardiac septum morphogenesis
GO:0071456--P:cellular response to hypoxia
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0003203--P:endocardial cushion morphogenesis
GO:0045184--P:establishment of protein localization
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0018205--P:peptidyl-lysine modification
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0031648--P:protein destabilization
GO:0034504--P:protein localization to nucleus
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0002027--P:regulation of heart rate
GO:0046677--P:response to antibiotic
GO:0007089--P:traversing start control point of mitotic cell cycle
GO:0003281--P:ventricular septum development

KEGG

mdo:100021398

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002039	Ailuropoda melanoleuca	75.66	0.00e+00	669.00
IUUC-Apl-003193	Anas platyrhynchos	69.53	3.00e-164	571.00
IUUC-Aca-004305	Anolis carolinensis	61.45	9.00e-130	457.00
IUUC-Ame-010675	Astyanax mexicanus	46.26	1.00e-86	313.00
IUUC-Bta-013270	Bos taurus	75.05	0.00e+00	647.00
IUUC-Cja-019744	Callithrix jacchus	74.90	0.00e+00	657.00
IUUC-Cfa-020807	Canis familiaris	73.89	6.00e-171	593.00
IUUC-Cpo-022182	Cavia porcellus	72.76	2.00e-174	605.00
IUUC-Cre-022828	Chlamydomonas reinhardtii	37.50	3.00e-06	42.70
IUUC-Csa-023541	Chlorocebus sabaeus	75.41	0.00e+00	644.00
IUUC-Cho-024831	Choloepus hoffmanni	60.66	3.00e-68	251.00
IUUC-Cin-025448	Ciona intestinalis	28.37	5.00e-19	87.80
IUUC-Csv-026151	Ciona savignyi	29.33	7.00e-10	57.40
IUUC-Dre-028419	Danio rerio	45.59	4.00e-54	205.00
IUUC-Dno-028950	Dasypus novemcinctus	74.39	0.00e+00	641.00
IUUC-Dor-031048	Dipodomys ordii	57.29	3.00e-138	485.00
IUUC-Ete-032264	Echinops telfairi	58.87	5.00e-141	494.00
IUUC-Eca-033301	Equus caballus	68.02	1.00e-174	605.00
IUUC-Eeu-035005	Erinaceus europaeus	67.28	1.00e-151	529.00
IUUC-Fca-035454	Felis catus	75.61	0.00e+00	639.00
IUUC-Fal-036720	Ficedula albicollis	67.55	3.00e-78	285.00
IUUC-Gmo-039296	Gadus morhua	41.80	8.00e-44	170.00
IUUC-Gga-040251	Gallus gallus	69.59	2.00e-166	578.00
IUUC-Ggo-044948	Gorilla gorilla	70.73	2.00e-168	585.00
IUUC-Hsa-046376	Homo sapiens	76.02	0.00e+00	652.00
IUUC-Itr-048328	Ictidomys tridecemlineatus	74.09	5.00e-177	613.00
IUUC-Lch-050037	Latimeria chalumnae	58.28	4.00e-122	431.00
IUUC-Loc-051837	Lepisosteus oculatus	53.25	9.00e-118	417.00
IUUC-Laf-053483	Loxodonta africana	73.74	9.00e-180	622.00
IUUC-Mcc-055294	Macaca mulatta	75.61	0.00e+00	648.00
IUUC-Mga-060007	Meleagris gallopavo	69.06	4.00e-156	544.00
IUUC-Mmr-060673	Microcebus murinus	75.20	0.00e+00	672.00
IUUC-Mmu-063207	Mus musculus	65.46	5.00e-142	497.00
IUUC-Mpu-065836	Mustela putorius furo	75.46	0.00e+00	656.00
IUUC-Mlu-068193	Myotis lucifugus	73.68	0.00e+00	630.00
IUUC-Nle-069927	Nomascus leucogenys	75.81	0.00e+00	650.00
IUUC-Opr-070590	Ochotona princeps	66.46	1.00e-161	562.00
IUUC-Ont-071984	Oreochromis niloticus	42.01	2.00e-79	289.00
IUUC-Oan-072744	Ornithorhynchus anatinus	75.96	2.00e-171	595.00
IUUC-Ocu-074071	Oryctolagus cuniculus	72.06	5.00e-179	621.00
IUUC-Ola-087329	Oryzias latipes	39.88	9.00e-73	267.00
IUUC-Oga-088135	Otolemur garnettii	67.81	7.00e-173	600.00
IUUC-Oar-089726	Ovis aries	74.55	0.00e+00	662.00
IUUC-Ptr-091399	Pan troglodytes	76.02	0.00e+00	652.00
IUUC-Pan-092720	Papio anubis	75.61	0.00e+00	648.00
IUUC-Psi-093591	Pelodiscus sinensis	68.20	1.00e-142	499.00
IUUC-Pma-094500	Petromyzon marinus	59.32	3.00e-19	87.80
IUUC-Pfo-096316	Poecilia formosa	42.72	2.00e-53	203.00
IUUC-Pab-097696	Pongo abelii	75.61	0.00e+00	644.00
IUUC-Pca-100974	Procavia capensis	72.64	0.00e+00	662.00
IUUC-Pva-102488	Pteropus vampyrus	70.51	2.00e-163	569.00
IUUC-Rno-105641	Rattus norvegicus	66.87	2.00e-155	541.00
IUUC-Sha-107314	Sarcophilus harrisii	91.00	0.00e+00	853.00
IUUC-Sar-112938	Sorex araneus	70.91	0.00e+00	635.00
IUUC-Ssc-115495	Sus scrofa	75.56	0.00e+00	631.00
IUUC-Tgu-116623	Taeniopygia guttata	68.82	3.00e-156	545.00
IUUC-Tru-117820	Takifugu rubripes	43.20	2.00e-74	273.00
IUUC-Tsy-119162	Tarsius syrichta	47.12	4.00e-58	218.00
IUUC-Tni-119793	Tetraodon nigroviridis	42.69	2.00e-42	166.00
IUUC-Tbe-127816	Tupaia belangeri	61.31	7.00e-107	380.00
IUUC-Ttr-129194	Tursiops truncatus	65.19	1.00e-150	526.00
IUUC-Vpa-130326	Vicugna pacos	70.73	5.00e-163	567.00
IUUC-Xtr-132216	Xenopus tropicalis	56.74	1.00e-130	459.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence