iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-068193

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02035064

Gene Name

MDM2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000009997.2	ENSMLUT00000009991.2	ENSMLUP00000009109.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	89.29	0.00e+00	784.00	IUUC-Hsa-046376
E3 activity/RING/RING	76.95	2.00e-179	625.00	IUUC-Mmu-063207
E3 activity/RING/RING	77.53	0.00e+00	652.00	IUUC-Rno-105641

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

PPTLRQMCNT SMSVSTDGAV STSQIPASEQ ETLVRPKPLL LKLLKSVGAQ KDTYTMKEVI 60
FYLGQYIMKK RLYDEKQQHI VYCSNDLLGD LFGVPSFSVK EHRKIYTMIY KNLVIVNQAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCCTACTC TCAGGCAGAT GTGCAATACC AGTATGTCTG TGTCTACGGA TGGTGCTGTG 60
AGCACCTCAC AGATTCCGGC TTCTGAACAA GAGACCCTGG TTGGTATTTT GTCTCAAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0043234--C:protein complex
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0003283--P:atrial septum development
GO:0003181--P:atrioventricular valve morphogenesis
GO:0001568--P:blood vessel development
GO:0001974--P:blood vessel remodeling
GO:0060411--P:cardiac septum morphogenesis
GO:0071456--P:cellular response to hypoxia
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0003203--P:endocardial cushion morphogenesis
GO:0045184--P:establishment of protein localization
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0018205--P:peptidyl-lysine modification
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0031648--P:protein destabilization
GO:0034504--P:protein localization to nucleus
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0002027--P:regulation of heart rate
GO:0046677--P:response to antibiotic
GO:0007089--P:traversing start control point of mitotic cell cycle
GO:0003281--P:ventricular septum development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002039	Ailuropoda melanoleuca	89.36	0.00e+00	794.00
IUUC-Apl-003193	Anas platyrhynchos	61.97	8.00e-151	526.00
IUUC-Aca-004305	Anolis carolinensis	55.92	2.00e-115	409.00
IUUC-Ame-010675	Astyanax mexicanus	43.82	2.00e-81	296.00
IUUC-Bta-013270	Bos taurus	87.25	0.00e+00	761.00
IUUC-Cja-019744	Callithrix jacchus	87.83	0.00e+00	764.00
IUUC-Cfa-020807	Canis familiaris	88.10	0.00e+00	731.00
IUUC-Cpo-022182	Cavia porcellus	83.84	0.00e+00	723.00
IUUC-Csa-023541	Chlorocebus sabaeus	89.05	0.00e+00	758.00
IUUC-Cho-024831	Choloepus hoffmanni	96.36	2.00e-53	202.00
IUUC-Cin-025448	Ciona intestinalis	28.16	3.00e-21	95.10
IUUC-Dre-028419	Danio rerio	43.70	8.00e-51	194.00
IUUC-Dno-028950	Dasypus novemcinctus	87.65	0.00e+00	768.00
IUUC-Dor-031048	Dipodomys ordii	73.33	6.00e-101	360.00
IUUC-Ete-032264	Echinops telfairi	71.64	2.00e-104	372.00
IUUC-Eca-033301	Equus caballus	78.92	0.00e+00	684.00
IUUC-Eeu-035005	Erinaceus europaeus	78.09	0.00e+00	636.00
IUUC-Fca-035454	Felis catus	89.86	0.00e+00	782.00
IUUC-Fal-036720	Ficedula albicollis	57.89	8.00e-68	250.00
IUUC-Gmo-039296	Gadus morhua	40.00	3.00e-45	175.00
IUUC-Gga-040251	Gallus gallus	61.21	2.00e-147	515.00
IUUC-Ggo-044948	Gorilla gorilla	81.14	0.00e+00	687.00
IUUC-Hsa-046376	Homo sapiens	89.70	0.00e+00	769.00
IUUC-Itr-048328	Ictidomys tridecemlineatus	85.17	0.00e+00	746.00
IUUC-Lch-050037	Latimeria chalumnae	56.43	3.00e-119	422.00
IUUC-Loc-051837	Lepisosteus oculatus	51.31	2.00e-114	405.00
IUUC-Laf-053483	Loxodonta africana	82.63	0.00e+00	714.00
IUUC-Mcc-055294	Macaca mulatta	89.29	0.00e+00	766.00
IUUC-Mga-060007	Meleagris gallopavo	61.84	2.00e-138	485.00
IUUC-Mmr-060673	Microcebus murinus	87.83	0.00e+00	773.00
IUUC-Mdo-063057	Monodelphis domestica	71.26	0.00e+00	650.00
IUUC-Mmu-063207	Mus musculus	76.95	3.00e-171	594.00
IUUC-Mpu-065836	Mustela putorius furo	89.25	0.00e+00	788.00
IUUC-Nle-069927	Nomascus leucogenys	89.09	0.00e+00	765.00
IUUC-Opr-070590	Ochotona princeps	79.80	0.00e+00	671.00
IUUC-Ont-071984	Oreochromis niloticus	40.83	2.00e-72	266.00
IUUC-Oan-072744	Ornithorhynchus anatinus	67.42	2.00e-158	551.00
IUUC-Ocu-074071	Oryctolagus cuniculus	87.60	0.00e+00	772.00
IUUC-Ola-087329	Oryzias latipes	38.64	3.00e-69	255.00
IUUC-Oga-088135	Otolemur garnettii	79.84	0.00e+00	702.00
IUUC-Oar-089726	Ovis aries	88.76	0.00e+00	804.00
IUUC-Ptr-091399	Pan troglodytes	89.29	0.00e+00	766.00
IUUC-Pan-092720	Papio anubis	89.29	0.00e+00	766.00
IUUC-Psi-093591	Pelodiscus sinensis	62.83	4.00e-123	434.00
IUUC-Pma-094500	Petromyzon marinus	35.62	1.00e-26	112.00
IUUC-Pfo-096316	Poecilia formosa	42.04	2.00e-72	266.00
IUUC-Pab-097696	Pongo abelii	88.69	0.00e+00	754.00
IUUC-Pca-100974	Procavia capensis	80.68	0.00e+00	731.00
IUUC-Pva-102488	Pteropus vampyrus	87.50	0.00e+00	716.00
IUUC-Rno-105641	Rattus norvegicus	77.53	3.00e-180	624.00
IUUC-Sha-107314	Sarcophilus harrisii	71.98	0.00e+00	656.00
IUUC-Sar-112938	Sorex araneus	81.14	0.00e+00	711.00
IUUC-Ssc-115495	Sus scrofa	86.82	0.00e+00	759.00
IUUC-Tgu-116623	Taeniopygia guttata	61.01	4.00e-145	508.00
IUUC-Tru-117820	Takifugu rubripes	40.54	2.00e-47	182.00
IUUC-Tsy-119162	Tarsius syrichta	62.26	2.00e-76	279.00
IUUC-Tbe-127816	Tupaia belangeri	86.73	1.00e-116	413.00
IUUC-Ttr-129194	Tursiops truncatus	78.15	9.00e-180	622.00
IUUC-Vpa-130326	Vicugna pacos	83.70	0.00e+00	702.00
IUUC-Xtr-132216	Xenopus tropicalis	53.91	1.00e-117	416.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence