iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088135

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03139810

Gene Name

MDM2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000034779.1	ENSOGAT00000030804.1	ENSOGAP00000021014.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	84.85	0.00e+00	742.00	IUUC-Hsa-046376
E3 activity/RING/RING	74.15	9.00e-175	610.00	IUUC-Mmu-063207
E3 activity/RING/RING	75.30	0.00e+00	638.00	IUUC-Rno-105641

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MCNTNMSVST DVTTSQIPAS EQETLVRPKP LLLKLLKSVG AQKDTYTMKE VIFYLGQYIM 60
TKRLYDEKQQ HIVYCSNDLL GDLFGVPSFS VKEHSPTRKI YTMIYRNLVV VNQQELSDSG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGCAATA CCAACATGTC TGTGTCTACT GATGTAACCA CCTCACAGAT TCCAGCTTCG 60
GAACAGGAGA CCCTGGTTGG TATTTTTGTC TCTCAGGTGT AACTTTTAAA AACAATTAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002039	Ailuropoda melanoleuca	83.43	0.00e+00	734.00
IUUC-Apl-003193	Anas platyrhynchos	60.12	4.00e-142	497.00
IUUC-Aca-004305	Anolis carolinensis	53.02	1.00e-103	370.00
IUUC-Ame-010675	Astyanax mexicanus	46.24	2.00e-53	203.00
IUUC-Bta-013270	Bos taurus	82.86	0.00e+00	701.00
IUUC-Cja-019744	Callithrix jacchus	83.10	0.00e+00	711.00
IUUC-Cfa-020807	Canis familiaris	82.29	0.00e+00	684.00
IUUC-Cpo-022182	Cavia porcellus	80.16	0.00e+00	664.00
IUUC-Cre-022828	Chlamydomonas reinhardtii	35.42	5.00e-06	42.00
IUUC-Csa-023541	Chlorocebus sabaeus	84.44	0.00e+00	717.00
IUUC-Cho-024831	Choloepus hoffmanni	93.86	1.00e-50	192.00
IUUC-Csv-026151	Ciona savignyi	30.00	4.00e-10	58.20
IUUC-Dno-028950	Dasypus novemcinctus	82.63	0.00e+00	711.00
IUUC-Dor-031048	Dipodomys ordii	77.04	2.00e-105	375.00
IUUC-Ete-032264	Echinops telfairi	73.88	3.00e-110	391.00
IUUC-Eca-033301	Equus caballus	73.94	0.00e+00	628.00
IUUC-Eeu-035005	Erinaceus europaeus	70.36	5.00e-162	563.00
IUUC-Fca-035454	Felis catus	83.03	0.00e+00	728.00
IUUC-Fal-036720	Ficedula albicollis	73.04	1.00e-39	156.00
IUUC-Gmo-039296	Gadus morhua	42.91	2.00e-46	179.00
IUUC-Gga-040251	Gallus gallus	61.01	2.00e-137	482.00
IUUC-Gac-041528	Gasterosteus aculeatus	43.75	3.00e-37	149.00
IUUC-Ggo-044948	Gorilla gorilla	75.75	0.00e+00	646.00
IUUC-Hsa-046376	Homo sapiens	84.44	0.00e+00	720.00
IUUC-Itr-048328	Ictidomys tridecemlineatus	83.03	0.00e+00	685.00
IUUC-Lch-050037	Latimeria chalumnae	52.23	5.00e-105	374.00
IUUC-Loc-051837	Lepisosteus oculatus	55.56	3.00e-72	265.00
IUUC-Laf-053483	Loxodonta africana	77.02	0.00e+00	671.00
IUUC-Mcc-055294	Macaca mulatta	84.65	0.00e+00	721.00
IUUC-Mga-060007	Meleagris gallopavo	61.14	3.00e-132	465.00
IUUC-Mmr-060673	Microcebus murinus	85.19	0.00e+00	759.00
IUUC-Mdo-063057	Monodelphis domestica	66.40	1.00e-170	592.00
IUUC-Mmu-063207	Mus musculus	74.15	3.00e-164	571.00
IUUC-Mpu-065836	Mustela putorius furo	82.42	0.00e+00	746.00
IUUC-Mlu-068193	Myotis lucifugus	79.84	0.00e+00	689.00
IUUC-Nle-069927	Nomascus leucogenys	84.65	0.00e+00	723.00
IUUC-Opr-070590	Ochotona princeps	78.95	0.00e+00	647.00
IUUC-Ont-071984	Oreochromis niloticus	44.58	2.00e-49	189.00
IUUC-Oan-072744	Ornithorhynchus anatinus	63.86	3.00e-147	514.00
IUUC-Ocu-074071	Oryctolagus cuniculus	83.64	0.00e+00	714.00
IUUC-Ola-087329	Oryzias latipes	41.61	1.00e-47	184.00
IUUC-Oar-090078	Ovis aries	82.42	0.00e+00	733.00
IUUC-Ptr-091399	Pan troglodytes	84.65	0.00e+00	723.00
IUUC-Pan-092720	Papio anubis	84.65	0.00e+00	721.00
IUUC-Psi-093591	Pelodiscus sinensis	72.29	2.00e-81	296.00
IUUC-Pma-094500	Petromyzon marinus	32.72	2.00e-27	115.00
IUUC-Pfo-096316	Poecilia formosa	43.33	1.00e-51	197.00
IUUC-Pab-097696	Pongo abelii	84.44	0.00e+00	716.00
IUUC-Pca-100974	Procavia capensis	75.65	0.00e+00	678.00
IUUC-Pva-102488	Pteropus vampyrus	76.97	2.00e-175	608.00
IUUC-Rno-105641	Rattus norvegicus	75.30	1.00e-172	599.00
IUUC-Sha-107314	Sarcophilus harrisii	64.86	1.00e-171	596.00
IUUC-Sar-112938	Sorex araneus	76.32	0.00e+00	660.00
IUUC-Ssc-115495	Sus scrofa	82.02	0.00e+00	691.00
IUUC-Tgu-116623	Taeniopygia guttata	59.91	1.00e-137	483.00
IUUC-Tru-117820	Takifugu rubripes	41.88	3.00e-43	169.00
IUUC-Tsy-119162	Tarsius syrichta	57.72	1.00e-67	249.00
IUUC-Tni-119793	Tetraodon nigroviridis	43.92	2.00e-47	183.00
IUUC-Tbe-127816	Tupaia belangeri	88.55	3.00e-119	422.00
IUUC-Ttr-129194	Tursiops truncatus	71.49	2.00e-164	572.00
IUUC-Vpa-130326	Vicugna pacos	76.36	0.00e+00	642.00
IUUC-Xtr-132216	Xenopus tropicalis	47.37	2.00e-105	376.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence