iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107314

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01189477

Gene Name

MDM2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000010284.1	ENSSHAT00000012089.1	ENSSHAP00000011991.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	8.80e-08	32.7	435	476

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplv.lpCgHvf.hadClqkwpglknssskefrCPlCr 46
           C iC++++k+g +v ++ gH++ +++C +k+      ++++  CP+Cr
   Q: 435  CVICQSRPKNGCIVhGRTGHLMaCFTCAKKL------KKRNKPCPVCR 476
           ********9984443889**888*****999......**********8 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

QMCNTKMSSD TEGALSTSQI PASEQEALVR PKPLLLKLLK FAGAQKDTFT MKEVLFYLGQ 60
YIMSKQLYDK KQQHIVYCSD DLLGDLFGVP SFSVKEHRRL YAMISRNLIA VNQQEFSSPN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNCT GGGGCTTGGC GGCGCCGGAT TCGAGGTGTG AGGGTGGGGC 60
CTAAGGGGCG GGTTTGAAGC CGCGGGCGGG AAGGGAAAGG AAGAACCGGA CGGGATTGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002039	Ailuropoda melanoleuca	75.81	0.00e+00	676.00
IUUC-Apl-003193	Anas platyrhynchos	69.92	7.00e-169	586.00
IUUC-Aca-004305	Anolis carolinensis	60.93	6.00e-130	457.00
IUUC-Ame-010675	Astyanax mexicanus	47.76	2.00e-89	322.00
IUUC-Bta-013270	Bos taurus	75.00	0.00e+00	642.00
IUUC-Cja-019744	Callithrix jacchus	74.95	0.00e+00	660.00
IUUC-Cfa-020807	Canis familiaris	72.06	7.00e-175	606.00
IUUC-Cpo-022182	Cavia porcellus	71.69	2.00e-172	598.00
IUUC-Cre-022828	Chlamydomonas reinhardtii	37.50	3.00e-06	42.70
IUUC-Csa-023541	Chlorocebus sabaeus	75.35	0.00e+00	645.00
IUUC-Cho-024831	Choloepus hoffmanni	60.36	5.00e-67	247.00
IUUC-Cin-025448	Ciona intestinalis	27.19	2.00e-18	85.90
IUUC-Csv-026151	Ciona savignyi	30.77	5.00e-11	61.20
IUUC-Dre-028419	Danio rerio	44.79	3.00e-54	206.00
IUUC-Dno-028950	Dasypus novemcinctus	74.65	0.00e+00	647.00
IUUC-Dor-031048	Dipodomys ordii	63.52	7.00e-80	291.00
IUUC-Ete-032264	Echinops telfairi	65.19	2.00e-89	322.00
IUUC-Eca-033301	Equus caballus	68.69	1.00e-177	615.00
IUUC-Eeu-035005	Erinaceus europaeus	65.71	4.00e-155	540.00
IUUC-Fca-035454	Felis catus	72.93	0.00e+00	639.00
IUUC-Fal-036720	Ficedula albicollis	71.05	6.00e-80	290.00
IUUC-Gmo-039296	Gadus morhua	42.97	5.00e-45	174.00
IUUC-Gga-040251	Gallus gallus	69.65	6.00e-169	587.00
IUUC-Gac-041528	Gasterosteus aculeatus	45.50	1.00e-35	144.00
IUUC-Ggo-044948	Gorilla gorilla	70.45	2.00e-171	595.00
IUUC-Hsa-046376	Homo sapiens	76.01	0.00e+00	655.00
IUUC-Itr-048328	Ictidomys tridecemlineatus	74.75	5.00e-180	623.00
IUUC-Lch-050037	Latimeria chalumnae	57.09	1.00e-120	426.00
IUUC-Loc-051837	Lepisosteus oculatus	53.04	6.00e-120	424.00
IUUC-Laf-053483	Loxodonta africana	72.89	3.00e-178	617.00
IUUC-Mcc-055294	Macaca mulatta	75.60	0.00e+00	651.00
IUUC-Mga-060007	Meleagris gallopavo	69.20	1.00e-154	539.00
IUUC-Mmr-060673	Microcebus murinus	75.15	0.00e+00	672.00
IUUC-Mdo-063057	Monodelphis domestica	88.75	0.00e+00	838.00
IUUC-Mmu-063207	Mus musculus	64.60	1.00e-146	512.00
IUUC-Mpu-065836	Mustela putorius furo	73.67	0.00e+00	670.00
IUUC-Mlu-068193	Myotis lucifugus	74.04	1.00e-180	625.00
IUUC-Nle-069927	Nomascus leucogenys	75.81	0.00e+00	653.00
IUUC-Opr-070590	Ochotona princeps	65.45	6.00e-160	556.00
IUUC-Ont-071984	Oreochromis niloticus	42.94	2.00e-80	292.00
IUUC-Oan-072744	Ornithorhynchus anatinus	76.52	6.00e-172	596.00
IUUC-Ocu-074071	Oryctolagus cuniculus	72.53	0.00e+00	629.00
IUUC-Ola-087329	Oryzias latipes	39.96	7.00e-73	267.00
IUUC-Oga-088135	Otolemur garnettii	66.93	8.00e-173	599.00
IUUC-Oar-089726	Ovis aries	75.20	0.00e+00	674.00
IUUC-Ptr-091399	Pan troglodytes	76.01	0.00e+00	655.00
IUUC-Pan-092720	Papio anubis	75.60	0.00e+00	651.00
IUUC-Psi-093591	Pelodiscus sinensis	68.12	1.00e-142	499.00
IUUC-Pma-094500	Petromyzon marinus	34.42	1.00e-25	108.00
IUUC-Pfo-096316	Poecilia formosa	42.31	4.00e-78	285.00
IUUC-Pab-097696	Pongo abelii	75.60	0.00e+00	646.00
IUUC-Pca-100974	Procavia capensis	71.80	0.00e+00	654.00
IUUC-Pva-102488	Pteropus vampyrus	70.82	8.00e-165	573.00
IUUC-Rno-105641	Rattus norvegicus	65.79	1.00e-156	545.00
IUUC-Sar-112938	Sorex araneus	70.77	0.00e+00	644.00
IUUC-Ssc-115495	Sus scrofa	75.00	0.00e+00	631.00
IUUC-Tgu-116623	Taeniopygia guttata	70.07	3.00e-157	547.00
IUUC-Tru-117820	Takifugu rubripes	40.78	3.00e-75	275.00
IUUC-Tsy-119162	Tarsius syrichta	45.97	4.00e-60	224.00
IUUC-Tni-119793	Tetraodon nigroviridis	42.69	1.00e-43	170.00
IUUC-Tbe-127816	Tupaia belangeri	61.35	1.00e-107	383.00
IUUC-Ttr-129194	Tursiops truncatus	65.49	2.00e-151	528.00
IUUC-Vpa-130326	Vicugna pacos	69.29	3.00e-166	577.00
IUUC-Xtr-132216	Xenopus tropicalis	56.40	7.00e-133	467.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence