iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	95.20	0.00e+00	1358.00	IUUC-Hsa-045863
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	96.66	0.00e+00	1381.00	IUUC-Mmu-063358

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MAAPEAWRAR SCWFCEVAAA TTMEATSREA APAKSSASGP SAPPALFELC GRAVSAHMGV 60
LESGVWALPG PILQSILPLL NIYYLERIEE TALKKGLSTQ AIWRRLWDEL MKTRPSSLES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGCGGGTGT CATTCTCGGG CTCGCGCACC TCCCCAAGAT GGCGGCGCCC GAGGCCTGGC 60
GCGCCCGGAG TTGCTGGTTC TGTGAGGTAG CGGCAGCAAC GACCATGGAG GCCACGTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0433--Leucine-rich repeat
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR032675--L_dom-like
IPR026137--Leu_rpt_41

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0042803--F:protein homodimerization activity
GO:0016567--P:protein ubiquitination

KEGG

rno:362566

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003769	Anas platyrhynchos	52.96	4.00e-164	571.00
IUUC-Aca-005345	Anolis carolinensis	47.76	2.00e-159	556.00
IUUC-Ame-011074	Astyanax mexicanus	32.69	5.00e-17	82.40
IUUC-Bta-012962	Bos taurus	90.25	0.00e+00	669.00
IUUC-Cja-019020	Callithrix jacchus	93.96	0.00e+00	1320.00
IUUC-Cfa-020137	Canis familiaris	94.23	0.00e+00	1310.00
IUUC-Cpo-021856	Cavia porcellus	94.10	0.00e+00	1308.00
IUUC-Csa-024137	Chlorocebus sabaeus	94.30	0.00e+00	1262.00
IUUC-Dre-027630	Danio rerio	28.94	7.00e-23	102.00
IUUC-Dno-028994	Dasypus novemcinctus	93.83	0.00e+00	1310.00
IUUC-Dse-031281	Dothistroma septosporum	26.80	1.10e+00	28.10
IUUC-Ete-032443	Echinops telfairi	86.40	1.00e-152	533.00
IUUC-Eca-033730	Equus caballus	88.71	0.00e+00	1204.00
IUUC-Eeu-034789	Erinaceus europaeus	91.01	0.00e+00	1174.00
IUUC-Fca-035714	Felis catus	92.75	0.00e+00	1244.00
IUUC-Fal-036765	Ficedula albicollis	55.68	3.00e-114	405.00
IUUC-Fso-038317	Fusarium solani	34.09	3.40e-01	29.30
IUUC-Gmo-038656	Gadus morhua	22.35	2.00e-04	38.90
IUUC-Gga-040164	Gallus gallus	50.24	2.00e-178	619.00
IUUC-Gac-041941	Gasterosteus aculeatus	34.51	2.00e-25	108.00
IUUC-Ggo-045159	Gorilla gorilla	94.46	0.00e+00	1313.00
IUUC-Hsa-045863	Homo sapiens	94.46	0.00e+00	1313.00
IUUC-Itr-048804	Ictidomys tridecemlineatus	94.58	0.00e+00	1256.00
IUUC-Lpe-051218	Leersia perrieri	31.25	4.00e-03	33.50
IUUC-Loc-052391	Lepisosteus oculatus	40.17	8.00e-36	145.00
IUUC-Lma-053146	Leptosphaeria maculans	32.39	4.40e-02	33.50
IUUC-Laf-054362	Loxodonta africana	93.86	0.00e+00	1297.00
IUUC-Mcc-055382	Macaca mulatta	94.44	0.00e+00	1199.00
IUUC-Meu-056890	Macropus eugenii	51.48	0.00e+00	680.00
IUUC-Mla-058850	Melampsora laricipopulina	25.93	1.30e-01	30.80
IUUC-Mga-059832	Meleagris gallopavo	52.04	2.00e-162	565.00
IUUC-Mmr-061383	Microcebus murinus	93.86	0.00e+00	1372.00
IUUC-Mdo-062507	Monodelphis domestica	59.88	0.00e+00	825.00
IUUC-Mmu-063358	Mus musculus	95.80	0.00e+00	1340.00
IUUC-Mpu-066845	Mustela putorius furo	94.49	0.00e+00	1318.00
IUUC-Mlu-067006	Myotis lucifugus	91.81	0.00e+00	1287.00
IUUC-Nle-069386	Nomascus leucogenys	94.21	0.00e+00	1309.00
IUUC-Opr-070396	Ochotona princeps	96.81	5.00e-118	419.00
IUUC-Oan-073068	Ornithorhynchus anatinus	54.19	0.00e+00	682.00
IUUC-Ocu-074054	Oryctolagus cuniculus	93.98	0.00e+00	1289.00
IUUC-Ogl-077410	Oryza glaberrima	27.66	1.30e-02	34.70
IUUC-Oin-079496	Oryza indica	27.66	1.20e-02	34.70
IUUC-Olo-080740	Oryza longistaminata	27.66	1.30e-02	34.70
IUUC-Oni-082831	Oryza nivara	27.66	1.40e-02	34.70
IUUC-Oru-084740	Oryza rufipogon	27.66	1.20e-02	35.40
IUUC-Osa-085903	Oryza sativa	27.66	1.20e-02	34.70
IUUC-Oga-088549	Otolemur garnettii	93.49	0.00e+00	1323.00
IUUC-Oar-089776	Ovis aries	93.32	0.00e+00	1211.00
IUUC-Ptr-090774	Pan troglodytes	94.46	0.00e+00	1313.00
IUUC-Pan-092510	Papio anubis	94.70	0.00e+00	1315.00
IUUC-Psi-094058	Pelodiscus sinensis	54.38	0.00e+00	629.00
IUUC-Pma-094518	Petromyzon marinus	30.81	4.00e-15	75.50
IUUC-Ppa-095577	Physcomitrella patens	27.00	9.20e-02	30.80
IUUC-Pfo-097181	Poecilia formosa	35.61	3.00e-26	113.00
IUUC-Pab-098616	Pongo abelii	81.28	0.00e+00	1030.00
IUUC-Pop-100048	Populus trichocarpa	30.00	2.00e-03	35.00
IUUC-Pca-101105	Procavia capensis	91.74	0.00e+00	979.00
IUUC-Pva-102749	Pteropus vampyrus	87.88	1.00e-162	566.00
IUUC-Sha-106634	Sarcophilus harrisii	53.57	1.00e-141	496.00
IUUC-Sar-113288	Sorex araneus	89.84	0.00e+00	688.00
IUUC-Ssc-115559	Sus scrofa	92.74	0.00e+00	1254.00
IUUC-Tgu-116561	Taeniopygia guttata	51.11	6.00e-177	614.00
IUUC-Tni-120099	Tetraodon nigroviridis	31.43	2.00e-17	83.60
IUUC-Tme-127168	Tuber melanosporum	22.86	9.20e-02	31.20
IUUC-Tbe-127527	Tupaia belangeri	89.16	5.00e-137	481.00
IUUC-Ttr-128532	Tursiops truncatus	93.45	0.00e+00	1211.00
IUUC-Xtr-131881	Xenopus tropicalis	41.76	2.00e-90	326.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence