iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132401

UUCD1 version

UUC-XeT-00018

Ensembl Protein ID

ENSXETP00000054929.2

UniProt Accession

A9JSR2; A9JSR2_XENTR

Genbank Protein ID

AAI55042.1; AAI57305.1

Protein Name

Kelch-like family member 12; LOC100127776 protein

Genbank Nucleotide ID

AAMC01095104; BC157304

Gene Name

klhl12; LOC100127776

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000025907.2	ENSXETT00000054929.2	ENSXETP00000054929.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.20e-18	67.4	29	92
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	1.90e-12	46.2	128	159

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +Dv+l v+ + f+ah+ivLaa+S++F a+f++el+e+  k+ v+i+++  + ++ ll+F+Yt ++
   Q: 29   CDVTLRVNLKDFPAHRIVLAACSDYFCAMFTNELSEKG-KPYVDIQGLTSSTMEILLDFVYTETV 92
           9***********************************98.***********************987 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           ++Nclgi++fA++++c dL++aa+ + +khF+
   Q: 128  PSNCLGIRDFAETHNCLDLMQAAEVYSQKHFP 159
           89*****************************6 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MAPKDIMTNS HAKSILNTMN SLRKSQTLCD VTLRVNLKDF PAHRIVLAAC SDYFCAMFTN 60
ELSEKGKPYV DIQGLTSSTM EILLDFVYTE TVHVTVENVQ ELLPAACLLQ LKGVKQACCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTGACATA ATGGCCCCTA AAGACATCAT GACAAACTCC CATGCTAAGT CAATATTAAA 60
CACCATGAAT TCTCTACGGA AAAGCCAAAC ATTATGTGAT GTGACATTGC GTGTTAATCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0030134--C:ER to Golgi transport vesicle
GO:0000139--C:Golgi membrane
GO:0048208--P:COPII vesicle coating
GO:0006513--P:protein monoubiquitination

KEGG

xtr:100127776

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002301	Ailuropoda melanoleuca	91.48	8.00e-169	586.00
IUUC-Apl-003339	Anas platyrhynchos	92.80	6.00e-149	520.00
IUUC-Aca-004418	Anolis carolinensis	91.91	1.00e-172	599.00
IUUC-Ame-011906	Astyanax mexicanus	60.38	3.00e-103	368.00
IUUC-Bta-012979	Bos taurus	90.29	7.00e-171	593.00
IUUC-Cja-019582	Callithrix jacchus	92.23	5.00e-174	604.00
IUUC-Cfa-020716	Canis familiaris	92.23	5.00e-174	603.00
IUUC-Cpo-022013	Cavia porcellus	91.91	8.00e-174	603.00
IUUC-Csa-023424	Chlorocebus sabaeus	92.23	1.00e-174	605.00
IUUC-Cho-024586	Choloepus hoffmanni	61.49	4.00e-104	371.00
IUUC-Dre-028344	Danio rerio	87.70	4.00e-164	570.00
IUUC-Dno-028854	Dasypus novemcinctus	92.23	2.00e-174	605.00
IUUC-Dor-030403	Dipodomys ordii	92.23	3.00e-174	604.00
IUUC-Ete-032963	Echinops telfairi	92.74	3.00e-139	488.00
IUUC-Eca-033282	Equus caballus	92.23	2.00e-174	605.00
IUUC-Fca-035487	Felis catus	92.23	2.00e-174	605.00
IUUC-Fal-037059	Ficedula albicollis	91.86	2.00e-170	592.00
IUUC-Gmo-039564	Gadus morhua	86.41	2.00e-164	572.00
IUUC-Gga-040629	Gallus gallus	91.86	5.00e-172	597.00
IUUC-Gac-042526	Gasterosteus aculeatus	87.70	4.00e-165	574.00
IUUC-Ggo-044839	Gorilla gorilla	92.23	2.00e-174	605.00
IUUC-Hsa-046742	Homo sapiens	92.23	2.00e-174	605.00
IUUC-Itr-048958	Ictidomys tridecemlineatus	92.23	2.00e-174	605.00
IUUC-Lch-049540	Latimeria chalumnae	89.64	2.00e-169	588.00
IUUC-Loc-051923	Lepisosteus oculatus	89.00	9.00e-168	583.00
IUUC-Laf-054370	Loxodonta africana	92.23	2.00e-174	605.00
IUUC-Mcc-054852	Macaca mulatta	92.23	2.00e-174	605.00
IUUC-Mga-059486	Meleagris gallopavo	89.84	4.00e-139	487.00
IUUC-Mmr-061777	Microcebus murinus	92.23	1.00e-173	603.00
IUUC-Mdo-061990	Monodelphis domestica	92.56	2.00e-174	605.00
IUUC-Mmu-064053	Mus musculus	91.91	4.00e-174	604.00
IUUC-Mpu-066623	Mustela putorius furo	92.23	2.00e-173	602.00
IUUC-Mlu-067648	Myotis lucifugus	91.91	2.00e-173	602.00
IUUC-Nle-069714	Nomascus leucogenys	92.23	2.00e-174	605.00
IUUC-Opr-071143	Ochotona princeps	91.91	8.00e-174	603.00
IUUC-Ont-071848	Oreochromis niloticus	88.35	2.00e-166	578.00
IUUC-Oan-073041	Ornithorhynchus anatinus	91.37	1.00e-152	531.00
IUUC-Ocu-074379	Oryctolagus cuniculus	91.91	1.00e-173	603.00
IUUC-Ola-087469	Oryzias latipes	88.67	8.00e-167	580.00
IUUC-Oga-088004	Otolemur garnettii	91.49	1.00e-128	451.00
IUUC-Oar-090144	Ovis aries	90.61	6.00e-171	593.00
IUUC-Ptr-091406	Pan troglodytes	92.23	2.00e-174	605.00
IUUC-Pan-092762	Papio anubis	92.23	2.00e-174	605.00
IUUC-Psi-093391	Pelodiscus sinensis	91.26	5.00e-172	597.00
IUUC-Pfo-096404	Poecilia formosa	88.35	5.00e-167	580.00
IUUC-Pab-098425	Pongo abelii	90.94	6.00e-171	593.00
IUUC-Pca-101093	Procavia capensis	92.41	2.00e-162	565.00
IUUC-Pva-102239	Pteropus vampyrus	89.13	7.00e-150	523.00
IUUC-Rno-104921	Rattus norvegicus	92.23	2.00e-174	605.00
IUUC-Sha-106625	Sarcophilus harrisii	92.56	6.00e-174	603.00
IUUC-Sar-113468	Sorex araneus	77.99	1.00e-140	492.00
IUUC-Ssc-116106	Sus scrofa	91.91	4.00e-173	600.00
IUUC-Tgu-117402	Taeniopygia guttata	82.37	4.00e-144	504.00
IUUC-Tru-117546	Takifugu rubripes	87.70	4.00e-166	577.00
IUUC-Tsy-118802	Tarsius syrichta	83.44	2.00e-149	522.00
IUUC-Tni-119999	Tetraodon nigroviridis	87.87	9.00e-164	570.00
IUUC-Tbe-127987	Tupaia belangeri	91.91	2.00e-173	601.00
IUUC-Ttr-128613	Tursiops truncatus	79.61	3.00e-144	505.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence