iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 304  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 391
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e vdp+l++sl +i+en   di+   ld tf+v+++ +ge+ ++eLkp+G++ipVt+eNk+eYv+l+v+
   Q: 392  GFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILEN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVN 476
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll+ F+e+elel+icG  +idv+d+k++t+ k+ +t+ds++++wFw+++e f++e r+++LqFv
   Q: 477  WRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKANTRLKH-CTPDSNVVKWFWKAVELFDEERRARLLQFV 564
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ da +++lP+++TCfn++++P+Y+s+e+l+ekLl+Aieet gF +
   Q: 565  TGSSRVPLQGFKALQgaagPRLFTIHQiDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAV 636
           **********************************************************************76 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

DQRLDLCKLG PNDNDTVRGQ IVVSLQSRDR IGTGGQVVDC SRLFDNDLPD GWEERRTASG 60
RIQYLNHITR TTQWERPTRP ASEYSSPGRP LSCFVDENTP ITGTNGATCG QSSDPRLAER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATCAGAGGT TGGATTTATG CAAACTGGGG CCAAATGACA ATGATACAGT TCGAGGACAA 60
ATTGTAGGTA AGTGTGGAAT TTAAAGTTTT GAGTTTTAGC TTCTTTTAAA CTGCCTTAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0046332--F:SMAD binding
GO:0005160--F:transforming growth factor beta receptor binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1901165--P:positive regulation of trophoblast cell migration
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	99.06	0.00e+00	1292.00
IUUC-Apl-003513	Anas platyrhynchos	97.49	0.00e+00	1280.00
IUUC-Aca-005358	Anolis carolinensis	97.35	0.00e+00	1274.00
IUUC-Ame-011320	Astyanax mexicanus	87.16	0.00e+00	1171.00
IUUC-Bta-013399	Bos taurus	99.06	0.00e+00	1288.00
IUUC-Cja-019355	Callithrix jacchus	98.90	0.00e+00	1292.00
IUUC-Cpo-022200	Cavia porcellus	99.21	0.00e+00	1292.00
IUUC-Cho-024804	Choloepus hoffmanni	99.03	0.00e+00	643.00
IUUC-Dre-027650	Danio rerio	89.28	0.00e+00	1211.00
IUUC-Dno-029534	Dasypus novemcinctus	99.06	0.00e+00	1293.00
IUUC-Ete-032715	Echinops telfairi	93.55	0.00e+00	1206.00
IUUC-Eca-033580	Equus caballus	99.37	0.00e+00	1295.00
IUUC-Eeu-034945	Erinaceus europaeus	97.68	0.00e+00	1211.00
IUUC-Fca-036047	Felis catus	99.21	0.00e+00	1026.00
IUUC-Fal-037275	Ficedula albicollis	97.35	0.00e+00	1268.00
IUUC-Gga-041060	Gallus gallus	93.76	0.00e+00	1206.00
IUUC-Gac-041295	Gasterosteus aculeatus	91.14	0.00e+00	1201.00
IUUC-Hsa-046726	Homo sapiens	99.06	0.00e+00	1292.00
IUUC-Itr-048042	Ictidomys tridecemlineatus	98.82	0.00e+00	1024.00
IUUC-Lch-050026	Latimeria chalumnae	94.86	0.00e+00	1237.00
IUUC-Loc-051760	Lepisosteus oculatus	88.58	0.00e+00	1189.00
IUUC-Laf-053753	Loxodonta africana	99.21	0.00e+00	1294.00
IUUC-Mcc-054815	Macaca mulatta	99.06	0.00e+00	1292.00
IUUC-Meu-056436	Macropus eugenii	80.84	0.00e+00	978.00
IUUC-Mmr-060806	Microcebus murinus	99.37	0.00e+00	1296.00
IUUC-Mdo-062805	Monodelphis domestica	97.01	0.00e+00	1262.00
IUUC-Mmu-064034	Mus musculus	99.37	0.00e+00	1293.00
IUUC-Mpu-066762	Mustela putorius furo	99.06	0.00e+00	1291.00
IUUC-Mlu-066981	Myotis lucifugus	99.21	0.00e+00	1293.00
IUUC-Nle-069804	Nomascus leucogenys	99.06	0.00e+00	1292.00
IUUC-Opr-070591	Ochotona princeps	93.24	0.00e+00	1200.00
IUUC-Ont-071239	Oreochromis niloticus	92.07	0.00e+00	1207.00
IUUC-Oan-072699	Ornithorhynchus anatinus	95.29	0.00e+00	1269.00
IUUC-Ocu-074913	Oryctolagus cuniculus	99.37	0.00e+00	1295.00
IUUC-Olu-087813	Ostreococcus lucimarinus	43.16	1.00e-85	310.00
IUUC-Oga-089116	Otolemur garnettii	94.97	0.00e+00	1229.00
IUUC-Oar-089366	Ovis aries	99.06	0.00e+00	1289.00
IUUC-Ptr-091382	Pan troglodytes	99.06	0.00e+00	1292.00
IUUC-Psi-093298	Pelodiscus sinensis	97.96	0.00e+00	1260.00
IUUC-Pma-094354	Petromyzon marinus	71.88	0.00e+00	927.00
IUUC-Pfo-096071	Poecilia formosa	89.07	0.00e+00	1195.00
IUUC-Pab-098682	Pongo abelii	99.06	0.00e+00	1292.00
IUUC-Pop-099520	Populus trichocarpa	46.08	1.00e-92	336.00
IUUC-Pca-100516	Procavia capensis	90.12	0.00e+00	636.00
IUUC-Pva-102754	Pteropus vampyrus	97.96	0.00e+00	1262.00
IUUC-Sha-107144	Sarcophilus harrisii	97.17	0.00e+00	1264.00
IUUC-Sar-113122	Sorex araneus	92.30	0.00e+00	1176.00
IUUC-Tgu-117112	Taeniopygia guttata	96.88	0.00e+00	1266.00
IUUC-Tru-118497	Takifugu rubripes	88.79	0.00e+00	1156.00
IUUC-Tsy-118819	Tarsius syrichta	98.94	0.00e+00	946.00
IUUC-Tni-120781	Tetraodon nigroviridis	90.08	0.00e+00	1184.00
IUUC-Tbe-127371	Tupaia belangeri	93.77	0.00e+00	1089.00
IUUC-Ttr-129305	Tursiops truncatus	89.88	0.00e+00	1085.00
IUUC-Vpa-130591	Vicugna pacos	87.26	0.00e+00	1100.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence